Substituted benzoyl derivatives and herbicidal compositions

ABSTRACT

A substituted benzoyl derivative of the formula: ##STR1## wherein R is a lower alkyl group, or a phenyl group unsubstituted or substituted by a lower alkyl group, halogen atom or a lower alkoxy group; 
     n is an integer of 2 or 3; 
     m is an integer of from 0 to 6, and when m is an integer of from 2 to 6, the plurality of R may be the same or different from one another; 
     l is an integer of 0, 1 or 2; 
     X is a halogen atom, a nitro group, a cyano group, a lower alkyl group, a lower alkoxy group, or a lower haloalkyl group; 
     Y is a hydrogen atom, a halogen atom, a nitro group, a lower alkyl group unsubstituted or substituted by a halogen atom or a lower alkoxy group, a lower alkoxy group, or a lower alkoxy carbonyl group; and 
     Z is a halogen atom, a nitro group, a cyano group, a trifluoromethyl group, a lower alkoxy group, a lower alkylthio group, a lower haloalkylthio group, a lower alkylsulfinyl group, a lower haloalkylsulfinyl group, a lower alkylsulfonyl group, or a lower haloalkylsulfonyl group.

BACKGROUND OF THE INVENTION

1. Field of the Invention

The present invention relates to novel substituted benzoyl derivatives, processes for their production and herbicidal compositions containing them.

2. Discussion of Background

As a result of extensive researches over years, the present inventors have found that the compounds of the present invention have herbicidal activities remarkably high as compared with conventional herbicides, and many of the compounds of the present invention have excellent selectivity for certain crop plants, particularly for gramineous crop plants such as corn and wheat, and thus are practically useful. The present invention has been accomplished on the basis of these discoveries.

Namely, the compounds of the present invention are so effective that the dose of the active ingredient per unit area can substantially be reduced as compared with conventional herbicidal compounds, and their phytotoxicity against crop plants is extremely low as compared with conventional herbicides. Therefore, their economical effects are substantial. Further, with the compounds of the present invention, it is possible to substantially reduce a danger of environmental pollution due to application of agricultural chemicals in large amounts, and little adverse effects to other crop plants due to the effects remaining in soil are observed. Therefore, the compounds of the present invention may be regarded as epoch-making herbicides.

SUMMARY OF THE INVENTION

The present invention provides a substituted benzoyl derivative of the formula: ##STR2## wherein R is a lower alkyl group, or a phenyl group unsubstituted or substituted by a lower alkyl group, halogen atom or a lower alkoxy group;

n is an integer of 2 or 3;

m is an integer of from 0 to 6, and when m is an integer of from 2 to 6, the plurality of R may be the same or different from one another;

l is an integer of 0, 1 or 2;

X is a halogen atom, a nitro group, a cyano group, a lower alkyl group, a lower alkoxy group, or a lower haloalkyl group;

Y is a hydrogen atom, a halogen atom, a nitro group, a lower alkyl group unsubstituted or substituted by a halogen atom or a lower alkoxy group, a lower alkoxy group, or a lower alkoxy carbonyl group; and

Z is a halogen atom, a nitro group, a cyano group, a trifluoromethyl group, a lower alkoxy group, a lower alkylthio group, a lower haloalkylthio group, a lower alkylsulfinyl group, a lower haloalkylsulfinyl group, a lower alkylsulfonyl group, or a lower haloalkylsulfonyl group.

The present invention also provides a herbicidal composition comprising a herbicidally effective amount of the substituted benzoyl derivative of the formula I and an agricultural carrier or diluent.

Now, the present invention will be described in detail with reference to the preferred embodiments.

The compound of the present invention is a novel compound not disclosed in literatures and has excellent physiological activities as a herbicide.

The compound of the present invention takes the following three structures by tautomerism: ##STR3##

In the above formulas, R, n, l, X, Y and Z are as defined above. The compound of the formula I of the present invention can easily be produced by the following reaction.

Reaction scheme ##STR4## In the above formulas, Q¹ is --N(CH₃)₂, --N(CH₂ CH₃)₂, ##STR5## Q² is a halogen atom, and R, n, m, l, X, Y, and Z are as defined above.

The compound of the formula II (l=0) can be obtained in good yield in accordance with the reaction disclosed in e.g. Synthesis, p. 368 (1978), J. Amer. Chem. Soc. Vol. 74, p. 1569 (1952). The compound of the formula III can be prepared in accordance with the methods disclosed in e.g. Journal of the Chemical Society, p. 1406 (1934), and the Journal of Organic Chemistry, Vol. 39, p.725 (1974).

The compounds of the formulas II and III are reacted in a suitable solvent, if necessary in the presence of an organic base such as pyridine or triethylamine, whereby the compound of the formula I (l=0) of the present invention can be prepared in good yield. If necessary, the compound of the formula I (l=0) of the present invention is reacted with an oxidizing agent such as mchloroperbenzoic acid or an aqueous hydrogen peroxide solution to obtain the compound of the formula I (l=1 or 2) of the present invention. Now, the compound of the formula I of the present invention will be described in further detail with reference to Preparation Examples of some representative compounds.

PREPARATION EXAMPLE 1 ##STR6##

To a solution of 27.6 9 of tetrahydrothiopyran-3-one (J. Amer. Chem. Soc. 74, 1569 (1952)) in 300 ml of benzene, 20.3 g of pyrrolidine and 0.5 g of p-toluene sulfonic acid were added, and the mixture was refluxed for five hours by means of a Dean-Stark trap. After cooling the mixture, the solvent was distilled off, and the residue was subjected to distillation under reduced pressure to obtain 36.3 g of a fraction distilled at a temperature of from 98° to 100° C. under 0.3 mmHg (yield 89%). By the ¹ H-NMR analysis, the product was ascertained to be the above identified pyrrolidine enamine.

PREPARATION EXAMPLE 2 ##STR7##

To a solution of 9 g of 4-methyl 3-oxotetrahydrothiophene (Synthesis 368 (1978)) in 80 ml of benzene, 6 g of pyrrolidine and 0.1 g of p-toluenesulfonic acid were added, and the mixture was refluxed for 3 hours by means of a Dean-Stark trap. After cooling the mixture, the solvent was distilled off and the residue was subjected to distillation under reduced pressure to obtain 9.6 g of a fraction distilled at a temperature of from 70° to 85° C. under 0.2 mmHg (yield: 74%). From the ¹ H-NMR analysis, the product was ascertained to be the above identified enamine.

PREPARATION EXAMPLE 3 (Compound No. 1 of the present invention) ##STR8##

3.8 g (22 mmol) of the enamine obtained in Preparation Example 1 was dissolved in 60 ml of methylene chloride, and 2.45 g (24 mmol) of triethylamine was added thereto. Then, 4.7 g (22 mmol) of 2,4-dichlorobenzoic acid chloride was added thereto, and the mixture was stirred at room temperature overnight. Then, 18 ml of a 2.5N hydrochloric acid aqueous solution was added thereto, and the mixture was stirred for two hours. The reaction solution was extracted with methylene chloride, washed with water and then dried under anhydrous sodium sulfate. After filtration and removal of the solvent by distillation, the product was purified by column chromatography to obtain 3.26 g of a crystal product (melting point: 134°-135° C). By the ¹ H-NMR and Mass analyses, the product was found to comprise two benzoyl molecules bonded to each other.

1.47 g (3.2 mmol) of the crystal product was dissolved in 10 ml of ethanol, and 10 ml of an aqueous solution having 0.27 g of sodium hydroxide dissolved therein, was added thereto. The mixture was stirred at room temperature overnight. Then, the mixture was acidified with an aqueous hydrochloric acid solution and then extracted with chloroform and dried. After filtration and removal of the solvent by distillation, the product was purified by column chromatography to obtain 0.68 g of a brown liquid. From the ¹ H-NMR and Mass analyses, the product was ascertained to be 2-(2,4-dichlorobenzoyl)-tetrahydrothiopyran-3-one [yield: 74%, brown liquid, refractive index n_(D) 20 1.6288.

¹ H-NMR δ value: ((CDCl₃)) 2.16(tt, J=6 Hz, 6 Hz, 2H) 2.60(t, J=6 Hz, 2H), 2.73(t, J=6 Hz, 2H), 7.13(s, 2H), 7.31(s, 1H)]

PREPARATION EXAMPLE 4 (Compound No. 1736 of the present invention) ##STR9##

2.5 g (15 mmol) of the enamine obtained in Preparation Example 2 was dissolved in 50 ml of methylene chloride, and 1.65 g (16 mmol) of triethylamine was added thereto. Then, 3.1 g (14 mmol) of 2,4-dichlorobenzoic acid chloride was added thereto, and the mixture was stirred at room temperature overnight. To the reaction solution, 20 ml of a 2.5N hydrochloric acid aqueous solution was added, and the mixture was stirred at room temperature for 4 hours. Then, the mixture was extracted with chloroform, washed with water and dried over anhydrous sodium sulfate. After filtration and removal of the solvent by distillation, the product was purified by column chromatography to obtain 1.57 g of a crystal product. From the ¹ H-NMR and Mass analyses, the product was ascertained to be 2-(2,4-dichlorobenzoyl)tetrahydrohydrothiophen-3-one.

[Yield: 37%, dark green crystal, melting point: 55°-58° C.,

¹ H-NMR δ value: ((CDCl₃)) 1.26-1.37(m, 3H), 2.73-3.28(m, 3H), 7.25-7.50(m, 3H), 12.5-13.5(b,1H)]

PREPARATION EXAMPLE 5 (Compound No. 32 of the present invention) ##STR10##

2.5 g (15 mmol) of the enamine obtained in Preparation Example 1 was dissolved in 60 ml of methylene chloride, and then 4.4 g (44 mmol) of triethylamine and 0.05 g of 4-dimethylaminopyridine were added thereto. The mixture was cooled with ice. Then, 3.2 g (14 mmol) of 4-chloro-2-nitrobenzoic acid chloride was gradually added thereto. The mixture was stirred at room temperature overnight. To the reaction solution, 20 ml of a 2.5N hydrochloric acid aqueous solution was added, and the mixture was stirred for further three hours. The mixture was extracted with chloroform, washed with water and dried over anhydrous sodium sulfate. After filtration and removal of the solvent by distillation, the product was purified by column chromatography to obtain 1.38 g of a reddish brown crystal product. From the ¹ H-NMR and Mass analyses, the product was ascertained to be 2-(4-chloro-2-nitrobenzoyl)-tetrahydrothiopyran-3-one.

[Yield: 32%, reddish brown crystal,

melting point: 113°-116° C.,

¹ H-NMR δ value: ((CDCl₃)) 2.16(tt, J=6 Hz, 6 Hz, 2H), 2.61(t, J=6 Hz, 2H), 2.72(t, J=6 Hz, 2H), 7.34(d, J=8 Hz, 1H), 7.71(dd, J=2 Hz, J=8 Hz, 1H), 8.15(d, J=2 Hz, 1H)]

PREPARATION EXAMPLE 6 (Compound No. 3 of the present invention) ##STR11##

Two g (11.8 mmol) of the enamine obtained in Preparation Example 1 and 3.6 g (3 equivalent) of triethylamine were dissolved in dry methylene chloride, and while cooling the mixture in an ice bath, 2.6 (11.8 mmol) of 2-chloro-4-nitrobenzoic acid chloride was dropwise added thereto, and the mixture was stirred at room temperature overnight.

Then, 20 ml of a 2N hydrochloric acid aqueous solution was added thereto, and the mixture was stirred for 3 hours. Then, water was added thereto, and the mixture was extracted with chloroform. The extract was dried over anhydrous sodium sulfate, and chloroform was distilled off under reduced pressure. The product was isolated by column chromatography to obtain 0.35 g (yield: 10%, melting point: 59.5°-62.5° C.) of desired 2-(2-chloro-4-nitrobenzoyl)tetrahydrothiopyran-3-one.

¹ H-NMR δ value: ((CDCl₃)) 2-3.2 ppm(m, 6H), 7.1-8.5 ppm(m, 3H), 15.2 ppm(br, 1H)

MS: M⁺ =299

Melting point: 59.5°-62.5° C. ]

PREPARATION EXAMPLE 7 (Compound No. 2 of the present invention) ##STR12##

1.33 g (7.9 mmol) of the enamine prepared in Preparation Example 1 and 1.2 g (11.9 mmol) of triethylamine were dissolved in 60 ml of tetrahydrofuran and cooled with ice. Then, 2 g (7.9 mmol) of 2-chloro-4-methylsulfonylbenzoic acid chloride was dissolved in 10 ml of tetrahydrofuran and gradually added to the above solution. The mixture was stirred at room temperature for one hour and then stirred at a temperature of from 60° to 70° C. for two hours. After cooling the mixture, the solvent was distilled off, and 50 ml of chloroform and 20 ml of an aqueous hydrochloric acid solution were added to the residue, and the mixture was stirred at room temperature for one hour. Then, the product was extracted with chloroform, washed with water and dried over anhydrous sodium sulfate. After filtration and removal of the solvent by distillation, the product was purified by column chromatography to obtain 0.32 g of slightly yellow crystal. From the ¹ H-NMR analysis, the product was ascertained to be 2-(2-chloro-4-methylsulfonylbenzoyl)-tetrahydrothiopyran-3-one.

[Yield: 12%, slightly yellow crystal,

melting point: 111°-113° C.,

¹ H-NMR δ value: ((CDCl₃)) 2.22(tt, J=6 Hz, 6 Hz, 2H), 2.68(t, J=6 Hz, 2H), 2.79(t, J=6 Hz, 2H), 3.09(s, 3H), 7.51(d, J=8 Hz, 1H), 7.90(dd, J=2 Hz, 8 Hz, 1H), 8.00(d, J=2 Hz, 1H), 15.77(b, 1H)]

PREPARATION EXAMPLE 8 (Compound No. 17 of the present invention) ##STR13##

Two g (11.8 mmol) of the enamine obtained in Preparation Example 1 and 1.8 g (1.5 equivalent) of triethylamine were dissolved in 50 ml of dry tetrahydrofuran, and 2.4 g (9 mmol) of 2-chloro-3-methyl-4-methylsulfonylbenzoic acid chloride was dropwise added thereto while cooling with an ice bath, and the mixture was stirred at room temperature overnight.

Then, tetrahydrofuran was distilled off under reduced pressure, and then, 30 ml of chloroform was added thereto. Further, 20 ml of a 2N hydrochloric acid aqueous solution was added thereto, and the mixture was stirred for three hours. After an addition of water, the product was extracted with chloroform and dried over anhydrous sodium sulfate. Then, chloroform was distilled off under reduced pressure, and the product was purified by column chromatography to obtain 0.33 g (yield: 10.6%, melting point: 141.5°-144.0° C.) of 2-(2-chloro-3-methyl-4-methylsulfonylbenzoyl)-tetrahydrothiopyran-3-one.

¹ H-NMR δ value: ((CDCl₃)) 1.8-3.0 ppm(m, 6H), 2.8 ppm(s, 3H), 3.1 ppm(s, 3H), 7.3 ppm(d, 2H), 8.05 ppm(d, 2H), 15.2 ppm(br, 1H)

MS: M⁺ =346, melting point: 141.5°-144.0° C.]

PREPARATION EXAMPLE 9 (Compound No. 29 of the present invention) ##STR14##

0.59 g (3.5 mmol) of the enamine obtained in Preparation Example 1 and 0.53 g (1.5 equivalent) of triethylamine were dissolved in 50 ml of dry ethoxycarbonyl-4-methylsulfonylbenzoic acid chloride was dropwise added, while cooling the solution with an ice bath. The mixture was stirred at room temperature for two hours. The mixture was then heated to 65° C. and stirred for further two hours.

Tetrahydrofuran was distilled off under reduced pressure, and 30 ml of chloroform was added to the residue. Further, 20 ml of a 2N hydrochloric acid aqueous solution was added thereto, and the mixture was stirred for 3 hours. After an addition of water, the product was extracted with chloroform and dried over anhydrous sodium sulfate. Chloroform was distilled off under reduced pressure, and the product was purified by column chromatography to obtain 0.13 g (yield: 10%) of 2-(2-methyl-3-ethoxycarbonyl-4-methylsulfonylbenzoyl)tetrahydrothiopyran-3-one.

¹ H-NMR δ value: ((CDCl₃)) 1.4 ppm(t, 3H), 2.3 ppm(s, 3H), 3.2 ppm(s, 3H), 1.7-3.3 ppm(m, 6H), 4.5 ppm(q, 2H), 7.1-8.2 ppm (m, 2H), 15.5 ppm(br)]

PREPARATION EXAMPLE 10 (Compound No. 30 of the present invention) ##STR15##

0.8 g (4.7 mmol) of the enamine obtained in Preparation Example 1 and 0.93 g (2 equivalent) of triethylamine were dissolved in 50 ml of dry tetrahydrofuran. Then, 1.27 g (4.6 mmol) of 2-methyl-3-methoxymethyl-4-methylsulfonylbenzoic acid chloride was dropwise added thereto while cooling with an ice bath. The mixture was stirred at room temperature overnight. Then, tetrahydrofuran was distilled off under reduced pressure, and 30 ml of chloroform was added to the residue, and 20 ml of a 2N hydrochloric acid aqueous solution was further added thereto. The mixture was stirred for 3 hours. After an addition of water, the product was extracted with chloroform and dried over anhydrous sodium sulfate. Then, chloroform was distilled off under reduced pressure, and the product was purified by column chromatography to obtain 0.53 g (yield: 32.4%, melting point: 151.5°-154.5° C.) of 2-(2-methyl-3- methoxymethyl-4-methylsulfonylbenzoyl)tetrahydrothiopyran-3-one.

[¹ H-NMR δ value: ((CDCl₃)) 2-3 ppm(6H, m), 2.4 ppm(3H, s), 3.15 ppm(3H, s), 3.45 ppm(3H, s), 4.9 ppm(2H, s), 7-8 ppm(2H)

Melting point: 151.5°-154.5° C.]

In a manner similar to the above reactions, compounds of the formula I of the present invention as identified in Tables 1 and 2 can be prepared. However, the present invention is not limited to such specific compounds.

The Compound Nos. in Tables 1 and 2 will be referred to in the subsequent Formulation Examples and Test Examples.

When the compound of the present invention is to be used as a herbicide, it is usually mixed with a suitable carrier, for instance, a solid carrier such as clay, talc, bentonite or diatomaceous earth, or a liquid carrier such as water, an alcohol (such as methanol or ethanol), an aromatic hydrocarbon (such as benzene, toluene or xylene), a chlorinated hydrocarbon, an ether, a ketone, an ester (such as ethyl acetate), or an acid amide (such as dimethylformamide). If desired, an emulsifier, a dispersing agent, a suspending agent, a penetrating agent, a spreader or a stabilizer may be added to prepare an optional formulation such as a liquid formulation, an emulsifiable concentrate, a wettable powder, a dust, a granule or a flowable. There is no particular restriction as to the content of the compound of the present invention as the active ingredient in such a formulation. However, the content is usually preferably within a range of from 0.10 to 90.0% by weight. Further, if desired, other herbicides, various insecticides, bacteriocides, plant growth regulating agents or synergism agents, may be combined at the time of the preparation of the formulations or at the time of the application. As such compounds to be combined, there may be mentioned, for instance, compounds disclosed in Farm Chemicals Handbook, the 75th Edition (1989).

The compound of the present invention can be applied to control various weeds not only in the agricultural and horticultural fields such as upland fields, paddy fields or orchards, but also in non-agricultural fields such as play grounds, non-used vacant fields or rail way sides.

The dose varies depending upon the application site, the season for application, the manner of application, the type of weeds to be controlled, the type of crop plants, etc. However, the dose is usually within a range of from 0.005 to 10 kg per hectare as the amount of the active ingredient.

Now, Formulation Examples of the herbicides containing the compounds of the present invention as active ingredients, will be given. However, it should be understood that the present invention is by no means restricted to such specific Examples. In the following Formulation Examples, "parts" means "parts by weight".

Liquid formulation

Active ingredient: 5-75 parts, preferably 10-50 parts, more preferably 15-40 parts,

Liquid carrier: 95-25 parts, preferably 88-30 parts, more preferably 82-40 parts,

Surfactant: 1-30 parts, preferably 2-20 parts.

Emulsifiable concentrate

Active ingredient: 1-50 parts, preferably 5-45 parts, more preferably 10-40 parts,

Surfactant: 1-30 parts, preferably 2-25 parts, more preferably 3-20 parts,

Liquid carrier: 20-95 parts, preferably 30-93 parts, more preferably 57-85 parts,

Dust

Active ingredient: 0.5-10 parts, preferably 15-40 parts,

Solid carrier: 95.9-90 parts.

Flowable

Active ingredient: 5-75 parts, preferably 10-50 parts,

Water: 94-25 parts, preferably 90-30 parts,

Surfactant: 1-30 parts, preferably 2-20 parts.

Wettable powder

Active ingredient: 2.5-90 parts, preferably 10-80 parts, more preferably 20-75 parts,

Surfactant: 0.5-20 parts, preferably 1-15 parts, more preferably 2-10 parts,

Liquid carrier: 5-90 parts, preferably, 7.5-88 parts, more preferably 16-56 parts.

Granule

Active ingredient: 0.1-30 parts,

Solid carrier: 99.5-70 parts.

The liquid formulation and the emulsifiable concentrate are prepared by dissolving the active ingredient in a liquid carrier containing a surfactant. The wettable powder is prepared by mixing a surfactant, a solid carrier and the active ingredient, followed by pulverization.

The dust is prepared by mixing a surfactant, a solid carrier and the active ingredient, if necessary, followed pulverization.

The flowable is prepared by suspending and dispersing the active ingredient in an aqueous solution containing a surfactant. The granule is prepared by mixing the active ingredient with an ajuvant.

FORMULATION EXAMPLE 1 Wettable powder

    ______________________________________                                         Compound No. 1 of the present invention                                                                  50 parts                                             Zeeklite PFP (tradename for a kaolin-type                                                                43 parts                                             clay, manufactured by Zeeklite Industries,                                     Co., Ltd.)                                                                     Sorpol 5039 (tradename for a mixture of a                                                                 5 parts                                             nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     Carplex (tradename for a coagulation-                                                                     2 parts                                             preventing agent composed of a mixture of a                                    surfactant and fine silica powder,                                             manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are homogeneously pulverized and mixed to form a wettable powder. In its use, the above wettable powder is diluted with water from 10 to 10,000 times and applied so that the active ingredient will be from 0.005 to 10 kg per hectare.

FORMULATION EXAMPLE 2 Emulsifiable concentrate

    ______________________________________                                         Compound No. 2 of the present invention                                                                  10 parts                                             Xylene                    70 parts                                             N,N-dimethylformamide     10 parts                                             Sorpol 2680 (tradename for a mixture of a                                                                10 parts                                             nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are homogeneously mixed to form an emulsifiable concentrate. In its use, the above emulsifiable concentrate is diluted with water from 10 to 10,000 times and applied so that the active ingredient will be from 0.005 to 10 kg per hectare.

FORMULATION EXAMPLE 3 Flowable

    ______________________________________                                         Compound No. 3 of the present invention                                                                   25     parts                                        Sorpol 3353 (tradename for a nonionic surfactant,                                                         10     parts                                        manufactured by Toho Chemical Co., Ltd.)                                       Runox 1000C (tradename for an anionic                                                                     0.5    part                                         surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     1% Xanthan gum aqueous solution (natural polymer)                                                         20     parts                                        Water                      44.5   parts                                        ______________________________________                                    

Sorpol 3353, Runox 1000C and the 1% Xanthan gum aqueous solution were uniformly dissolved in water, then Compound No. 3 of the present invention was added, and the mixture was thoroughly stirred. Then, the mixture was subjected to wet pulverization by a sand mil to obtain a flowable. In its use, the above flowable is diluted from 10 to 10,000 times and applied so that the active ingredient will be 0.005 to 10 kg per hectare.

FORMULATION EXAMPLE 4 Liquid formulation

    ______________________________________                                         Compound No. 7 of the present invention                                                                  20 parts                                             Sorpol W-150 (tradename for a nonionic                                                                   10 part                                              surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     Water                     70 parts                                             ______________________________________                                    

The above ingredients are uniformly mixed to form a liquid formulation. In its use, the above liquid formulation is diluted from 10 to 10,000 times and applied so that the active ingredient will be from 0.005 to 10 kg per hectare.

FORMULATION EXAMPLE 5 Liquid formulation

    ______________________________________                                         Compound No. 17 of the present invention                                                                 30 parts                                             Nippol (tradename for a nonionic                                                                         10 parts                                             surfactant, manufactured by Nissan                                             Chemical Industries Ltd.)                                                      Water                     60 parts                                             ______________________________________                                    

The above ingredients are homogeneously mixed to obtain a liquid formulation. In its use, the above liquid formulation is diluted from 10 to 10,000 times and applied to so that the active ingredient will be from 0,005 to 10 kg per hectare.

FORMULATION EXAMPLE 6 Wettable powder

    ______________________________________                                         Compound No. 1736 of the present invention                                                               20 parts                                             Zeeklite PFP (tradename for a kaolin-type                                                                73 parts                                             clay, manufactured by Zeeklite Industries,                                     Co., Ltd.)                                                                     Sorpol 5039 (tradename for a mixture of a                                                                 5 parts                                             nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     Carplex (tradename for a coagulation-                                                                     2 parts                                             preventing agent composed of a mixture of a                                    surfactant and fine silica powder,                                             manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are homogeneously pulverized and mixed to form a wettable powder.

FORMULATION EXAMPLE 7 Wettable powder

    ______________________________________                                         Compound No. 29 of the present invention                                                                 30 parts                                             Zeeklite PFP (tradename for a kaolin-type                                                                63 parts                                             clay, manufactured by Zeeklite Industries,                                     Co., Ltd.)                                                                     Sorpol 5039 (tradename for a mixture of a                                                                 5 parts                                             nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     Carplex (tradename for a coagulation-                                                                     2 parts                                             preventing agent composed of a mixture of a                                    surfactant and fine silica powder,                                             manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are homogeneously pulverized and mixed to form a wettable powder.

FORMULATION EXAMPLE 8 Granule

    ______________________________________                                         Compound No. 32 of the present invention                                                                  5 parts                                             Bentonite                 54 parts                                             Talc                      40 parts                                             Calcium lignin sulfonate   1 part                                              ______________________________________                                    

The above ingredients were homogeneously mixed and pulverized, and after an addition of a small amount of water, the mixture was stirred, mixed and granulated by an extrusion-type granulating machine, followed by drying to obtain a granule. In its use, the above granule is applied so that the active ingredient will be from 0.005 to 10 kg per hectare.

Now, the herbicidal activities of the compounds of the present invention will be described in detail with reference to the following Test Examples.

TEST EXAMPLE 1 Test on the herbicidal effects in soil treatment

A plastic box having a length of 30 cm, a width of 22 cm and a depth of 6 cm was filled with a sterilized diluvium soil, and seeds of Echinochloa crus-galli, Digitaria adscendens, Cyperus microira, Solanum nigrum, Galinsoga ciliata, Rorripa indica, Zea mays and Triticum aestivum were sown, and the soil was covered thereon in the thickness of about 1.5 cm, and then a herbicide solution was applied onto the surface of the soil uniformly so that the active ingredient was distributed at a predetermined concentration. The herbicide solution was prepared by diluting the liquid formulation, the wettable powder, the emulsifiable concentrate or the flowable as described in the foregoing Formulation Examples with water and applied onto the entire soil surface by means of a small spray. Three weeks after the application of the herbicidal solution, the herbicidal effects against each weed were determined on the basis of the following standard ratings.

Standard ratings:

5: Growth control rate of more than 90% (almost completely withered)

4: Growth control rate of from 70 to 90%

3: Growth control rate of from 40 to 70%

2: Growth control rate of from 20 to 40%

1: Growth control rate of from 5 to 20%

0: Growth control rate of less than 5% (almost non-effective)

The above growth control rates were calculated by the following equation: ##EQU1## where T: Weight of the weed growth above the soil surface of the treated area

N: Weight of the weed growth above the soil surface of the non-treated area

The results thereby obtained are shown in Table 3.

TEST EXAMPLE 2 Test 1 on the herbicidal effects in foliage treatment

A plastic box having a length of 30 cm, a width of 22 cm and a depth of 6 cm was filled with a sterilized diluvium soil, and seeds of Echinochloa crus-galli, Digitaria adscendens, Cyperus microiria, Solanum nigrum, Galinsoga ciliata, Rorripa indica, Zea mays and Triticum aestivum were spot-wisely sown, and the soil was covered thereon in a thickness of about 1.5 cm. When the various weeds and crop plant grew to the 2 or 3 leaf stage, a herbicidal solution was uniformly sprayed on the foliages so that the active ingredient was applied in a predetermined concentration.

The herbicidal solution was prepared by diluting the liquid formulation, the wettable powder, the emulsifiable concentrate or the flowable as described in the above Formulation Examples with water and applied onto the entire surface of the foliages of the weeds and the crop plants by a small spray. Three weeks after the application of the herbicide solution, the herbicidal effects against each weed and the phytotoxicities against each crop plant were determined on the basis of the standard ratings described in Test Example 1. The results are shown in Table 4.

In the following Tables 1 and 2, Me means a methyl group, Et means an ethyl group and Ph means a phenyl group.

In Tables 3 and 4, the following abbreviations are used.

EC: Echinochloa crus-galli (barnyardgrass)

Dose: Dose of active ingredient (kg/ha)

DI: Digitaria adscendens (large crabgrass)

CY: Cyperus microiria (flatsedge)

SO: Solanum nigrum (black nigthshade)

GA: Galinsoga ciliata (hairy galinsoga)

RO: Rorripa indica

ZE: Zea mays (corn)

TR: Triticum aestivum (wheat)

                                      TABLE 1                                      __________________________________________________________________________      ##STR16##                                                                     Compound                                                                       No. of                        Characteristic                                   present                       (Physical                                        invention                                                                            (R).sub.m                                                                             L X  Y      Z    property)                                        __________________________________________________________________________     1     --     0 Cl H      Cl   Brown liquid                                                                   n.sub.D.sup.25 1.6288                            2     --     0 Cl H      SO.sub.2 Me                                                                         Slightly yellow crystal                                                        m.p. 111˜113° C.                    3     --     0 Cl H      NO.sub.2                                                                            Reddish brown crystal                                                          m.p. 59.5˜62.5° C.                  4     --     0 Cl H      OMe                                                   5     --     0 Cl H      Me                                                    6     --     0 Cl H      Br                                                    7     --     0 Cl H      F    Yellowish brown                                                                liquid                                           8     --     0 Cl H      SMe                                                   9     --     0 Cl H      S(O)Me                                                10    --     0 Cl H      CF.sub.3                                              11    --     0 Cl H      CN                                                    12    --     0 Cl Cl     Cl                                                    13    --     0 Cl Cl     OMe                                                   14    --     0 Cl Cl     SMe                                                   15    --     0 Cl Cl     SO.sub.2 Me                                           16    --     0 Cl Me     Cl   Yellow liquid                                                                  n.sub.D.sup.20 1.6312                            17    --     0 Cl Me     SO.sub.2 Me                                                                         Yellow crystal                                                                 m.p. 141.5˜144° C.                  18    --     0 Cl OMe    Cl                                                    19    --     0 Cl OMe    Br                                                    20    --     0 Cl OMe    SO.sub.2 Me                                           21    --     0 Cl OEt    Br                                                    22    --     0 Br H      OMe                                                   23    --     0 F  H      F                                                     24    --     0 I  I      I                                                     25    --     0 Me H      CN                                                    26    --     0 Me H      Me                                                    27    --     0 Me H      OMe                                                   28    --     0 Me Cl     Cl                                                    29    --     0 Me CO.sub.2 Et                                                                           SO.sub.2 Me                                                                         Yellow semicrystal                               30    --     0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                                                         Slightly yellow crystal                                                        m.p. 151.5˜154.5° C.                31    --     0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           32    --     0 NO.sub.2                                                                          H      Cl   Reddish brown crystal                                                          m.p. 113˜116° C.                    33    --     0 NO.sub.2                                                                          H      Br                                                    34    --     0 NO.sub.2                                                                          H      F                                                     35    --     0 NO.sub.2                                                                          H      CN                                                    36    --     0 NO.sub.2                                                                          H      SMe                                                   37    --     0 NO.sub.2                                                                          H      CF.sub.3                                                                            Slightly yellow crystal                                                        m.p. 104˜106° C.                    38    --     0 NO.sub.2                                                                          OMe    Cl                                                    39    --     0 NO.sub.2                                                                          OMe    CF.sub.3                                              40    --     0 CF.sub.3                                                                          H      Cl                                                    41    --     0 CF.sub.3                                                                          H      Br                                                    42    --     0 CF.sub.3                                                                          H      SMe                                                   43    --     0 CF.sub.3                                                                          H      CF.sub.3                                              44    --     0 OMe                                                                               H      Cl                                                    45    --     0 OMe                                                                               H      OMe  Slightly yellow crystal                                                        m.p. 101-104° C.                          46    --     1 Cl H      Cl                                                    47    --     1 Cl H      SO.sub.2 Me                                           48    --     1 Cl H      NO.sub.2                                              49    --     1 Cl H      OMe                                                   50    --     1 Cl H      Me                                                    51    --     1 Cl H      Br                                                    52    --     1 Cl H      F                                                     53    --     1 Cl H      SMe                                                   54    --     1 Cl H      S(O)Me                                                55    --     1 Cl H      CF.sub.3                                              56    --     1 Cl H      CN                                                    57    --     1 Cl Cl     Cl                                                    58    --     1 Cl Cl     OMe                                                   59    --     1 Cl Cl     SMe                                                   60    --     1 Cl Cl     SO.sub.2 Me                                           61    --     1 Cl Me     Cl                                                    62    --     1 Cl Me     SO.sub.2 Me                                           63    --     1 Cl OMe    Cl                                                    64    --     1 Cl OMe    Br                                                    65    --     1 Cl OMe    SO.sub.2 Me                                           66    --     1 Cl OEt    Br                                                    67    --     1 Br H      OMe                                                   68    --     1 F  H      F                                                     69    --     1 I  I      I                                                     70    --     1 Me H      CN                                                    71    --     1 Me H      Me                                                    72    --     1 Me H      OMe                                                   73    --     1 Me Cl     Cl                                                    74    --     1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           75    --     1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           76    --     1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           77    --     1 NO.sub.2                                                                          H      Cl                                                    78    --     1 NO.sub.2                                                                          H      Br                                                    79    --     1 NO.sub.2                                                                          H      F                                                     80    --     1 NO.sub.2                                                                          H      CN                                                    81    --     1 NO.sub.2                                                                          H      SMe                                                   82    --     1 NO.sub.2                                                                          H      CF.sub.3                                              83    --     1 NO.sub.2                                                                          OMe    Cl                                                    84    --     1 NO.sub.2                                                                          OMe    CF.sub.3                                              85    --     1 CF.sub.3                                                                          H      Cl                                                    86    --     1 CF.sub.3                                                                          H      Br                                                    87    --     1 CF.sub.3                                                                          H      SMe                                                   88    --     1 CF.sub.3                                                                          H      CF.sub.3                                              89    --     1 OMe                                                                               H      Cl                                                    90    --     1 OMe                                                                               H      OMe                                                   91    --     2 Cl H      Cl                                                    92    --     2 Cl H      SO.sub.2 Me                                           93    --     2 Cl H      NO.sub.2                                              94    --     2 Cl H      OMe                                                   95    --     2 Cl H      Me                                                    96    --     2 Cl H      Br                                                    97    --     2 Cl H      F                                                     98    --     2 Cl H      SMe                                                   99    --     2 Cl H      S(O)Me                                                100   --     2 Cl H      CF.sub.3                                              101   --     2 Cl H      CN                                                    102   --     2 Cl Cl     Cl                                                    103   --     2 Cl Cl     OMe                                                   104   --     2 Cl Cl     SMe                                                   105   --     2 Cl Cl     SO.sub.2 Me                                           106   --     2 Cl Me     Cl                                                    107   --     2 Cl Me     SO.sub.2 Me                                           108   --     2 Cl OMe    Cl                                                    109   --     2 Cl OMe    Br                                                    110   --     2 Cl OMe    SO.sub.2 Me                                           111   --     2 Cl OEt    Br                                                    112   --     2 Br H      OMe                                                   113   --     2 F  H      F                                                     114   --     2 I  I      I                                                     115   --     2 Me H      CN                                                    116   --     2 Me H      Me                                                    117   --     2 Me H      OMe                                                   118   --     2 Me Cl     Cl                                                    119   --     2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           120   --     2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           121   --     2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           122   --     2 NO.sub.2                                                                          H      Cl                                                    123   --     2 NO.sub.2                                                                          H      Br                                                    124   --     2 NO.sub.2                                                                          H      F                                                     125   --     2 NO.sub.2                                                                          H      CN                                                    126   --     2 NO.sub.2                                                                          H      SMe                                                   127   --     2 NO.sub.2                                                                          H      CF.sub.3                                              128   --     2 NO.sub.2                                                                          OMe    Cl                                                    129   --     2 NO.sub.2                                                                          OMe    CF.sub.3                                              130   --     2 CF.sub.3                                                                          H      Cl                                                    131   --     2 CF.sub.3                                                                          H      Br                                                    132   --     2 CF.sub.3                                                                          H      SMe                                                   133   --     2 CF.sub.3                                                                          H      CF.sub.3                                              134   --     2 OMe                                                                               H      Cl                                                    135   --     2 OMe                                                                               H      OMe                                                   136   4-Me   0 Cl H      Cl                                                    137   4-Me   0 Cl H      SO.sub.2 Me                                           138   4-Me   0 Cl H      NO.sub.2                                              139   4-Me   0 Cl H      OMe                                                   140   4-Me   0 Cl H      Me                                                    141   4-Me   0 Cl H      Br                                                    142   4-Me   0 Cl H      F                                                     143   4-Me   0 Cl H      SMe                                                   144   4-Me   0 Cl H      S(O)Me                                                145   4-Me   0 Cl H      CF.sub.3                                              146   4-Me   0 Cl H      CN                                                    147   4-Me   0 Cl Cl     Cl                                                    148   4-Me   0 Cl Cl     OMe                                                   149   4-Me   0 Cl Cl     SMe                                                   150   4-Me   0 Cl Cl     SO.sub.2 Me                                           151   4-Me   0 Cl Me     Cl                                                    152   4-Me   0 Cl Me     SO.sub.2 Me                                           153   4-Me   0 Cl OMe    Cl                                                    154   4-Me   0 Cl OMe    Br                                                    155   4-Me   0 Cl OMe    SO.sub.2 Me                                           156   4-Me   0 Cl OEt    Br                                                    157   4-Me   0 Br H      OMe                                                   158   4-Me   0 F  H      F                                                     159   4-Me   0 I  I      I                                                     160   4-Me   0 Me H      CN                                                    161   4-Me   0 Me H      Me                                                    162   4-Me   0 Me H      OMe                                                   163   4-Me   0 Me Cl     Cl                                                    164   4-Me   0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           165   4-Me   0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           166   4-Me   0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           167   4-Me   0 NO.sub.2                                                                          H      Cl                                                    168   4-Me   0 NO.sub.2                                                                          H      Br                                                    169   4-Me   0 NO.sub.2                                                                          H      F                                                     170   4-Me   0 NO.sub.2                                                                          H      CN                                                    171   4-Me   0 NO.sub.2                                                                          H      SMe                                                   172   4-Me   0 NO.sub.2                                                                          H      CF.sub.3                                              173   4-Me   0 NO.sub.2                                                                          OMe    Cl                                                    174   4-Me   0 NO.sub.2                                                                          OMe    CF.sub.3                                              175   4-Me   0 CF.sub.3                                                                          H      Cl                                                    176   4-Me   0 CF.sub.3                                                                          H      Br                                                    177   4-Me   0 CF.sub.3                                                                          H      SMe                                                   178   4-Me   0 CF.sub.3                                                                          H      CF.sub.3                                              179   4-Me   0 OMe                                                                               H      Cl                                                    180   4-Me   0 OMe                                                                               H      OMe                                                   181   4-Me   1 Cl H      Cl                                                    182   4-Me   1 Cl H      SO.sub.2 Me                                           183   4-Me   1 Cl H      NO.sub.2                                              184   4-Me   1 Cl H      OMe                                                   185   4-Me   1 Cl H      Me                                                    186   4-Me   1 Cl H      Br                                                    187   4-Me   1 Cl H      F                                                     188   4-Me   1 Cl H      SMe                                                   189   4-Me   1 Cl H      S(O)Me                                                190   4-Me   1 Cl H      CF.sub.3                                              191   4-Me   1 Cl H      CN                                                    192   4-Me   1 Cl Cl     Cl                                                    193   4-Me   1 Cl Cl     OMe                                                   194   4-Me   1 Cl Cl     SMe                                                   195   4-Me   1 Cl Cl     SO.sub.2 Me                                           196   4-Me   1 Cl Me     Cl                                                    197   4-Me   1 Cl Me     SO.sub.2 Me                                           198   4-Me   1 Cl OMe    Cl                                                    199   4-Me   1 Cl OMe    Br                                                    200   4-Me   1 Cl OMe    SO.sub.2 Me                                           201   4-Me   1 Cl OEt    Br                                                    202   4-Me   1 Br H      OMe                                                   203   4-Me   1 F  H      F                                                     204   4-Me   1 I  I      I                                                     205   4-Me   1 Me H      CN                                                    206   4-Me   1 Me H      Me                                                    207   4-Me   1 Me H      OMe                                                   208   4-Me   1 Me Cl     Cl                                                    209   4-Me   1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           210   4-Me   1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           211   4-Me   1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           212   4-Me   1 NO.sub.2                                                                          H      Cl                                                    213   4-Me   1 NO.sub.2                                                                          H      Br                                                    214   4-Me   1 NO.sub.2                                                                          H      F                                                     215   4-Me   1 NO.sub.2                                                                          H      CN                                                    216   4-Me   1 NO.sub.2                                                                          H      SMe                                                   217   4-Me   1 NO.sub.2                                                                          H      CF.sub.3                                              218   4-Me   1 NO.sub.2                                                                          OMe    Cl                                                    219   4-Me   1 NO.sub.2                                                                          OMe    CF.sub.3                                              220   4-Me   1 CF.sub.3                                                                          H      Cl                                                    221   4-Me   1 CF.sub.3                                                                          H      Br                                                    222   4-Me   1 CF.sub.3                                                                          H      SMe                                                   223   4-Me   1 CF.sub.3                                                                          H      CF.sub.3                                              224   4-Me   1 OMe                                                                               H      Cl                                                    225   4-Me   1 OMe                                                                               H      OMe                                                   226   4-Me   2 Cl H      Cl                                                    227   4-Me   2 Cl H      SO.sub.2 Me                                           228   4-Me   2 Cl H      NO.sub.2                                              229   4-Me   2 Cl H      OMe                                                   230   4-Me   2 Cl H      Me                                                    231   4-Me   2 Cl H      Br                                                    232   4-Me   2 Cl H      F                                                     233   4-Me   2 Cl H      SMe                                                   234   4-Me   2 Cl H      S(O)Me                                                235   4-Me   2 Cl H      CF.sub.3                                              236   4-Me   2 Cl H      CN                                                    237   4-Me   2 Cl Cl     Cl                                                    238   4-Me   2 Cl Cl     OMe                                                   239   4-Me   2 Cl Cl     SMe                                                   240   4-Me   2 Cl Cl     SO.sub. 2 Me                                          241   4-Me   2 Cl Me     Cl                                                    242   4-Me   2 Cl Me     SO.sub.2 Me                                           243   4-Me   2 Cl OMe    Cl                                                    244   4-Me   2 Cl OMe    Br                                                    245   4-Me   2 Cl OMe    SO.sub.2 Me                                           246   4-Me   2 Cl OEt    Br                                                    247   4-Me   2 Br H      OMe                                                   248   4-Me   2 F  H      F                                                     249   4-Me   2 I  I      I                                                     250   4-Me   2 Me H      CN                                                    251   4-Me   2 Me H      Me                                                    252   4-Me   2 Me H      OMe                                                   253   4-Me   2 Me Cl     Cl                                                    254   4-Me   2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           255   4-Me   2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           256   4-Me   2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           257   4-Me   2 NO.sub.2                                                                          H      Cl                                                    258   4-Me   2 NO.sub.2                                                                          H      Br                                                    259   4-Me   2 NO.sub.2                                                                          H      F                                                     260   4-Me   2 NO.sub.2                                                                          H      CN                                                    261   4-Me   2 NO.sub.2                                                                          H      SMe                                                   262   4-Me   2 NO.sub.2                                                                          H      CF.sub.3                                              263   4-Me   2 NO.sub.2                                                                          OMe    Cl                                                    264   4-Me   2 NO.sub.2                                                                          OMe    CF.sub.3                                              265   4-Me   2 CF.sub.3                                                                          H      Cl                                                    266   4-Me   2 CF.sub.3                                                                          H      Br                                                    267   4-Me   2 CF.sub.3                                                                          H      SMe                                                   268   4-Me   2 CF.sub.3                                                                          H      CF.sub.3                                              269   4-Me   2 OMe                                                                               H      Cl                                                    270   4-Me   2 OMe                                                                               H      OMe                                                   271   5-Me   0 Cl H      Cl                                                    272   5-Me   0 Cl H      SO.sub.2 Me                                           273   5-Me   0 Cl H      NO.sub.2                                              274   5-Me   0 Cl H      OMe                                                   275   5-Me   0 Cl H      Me                                                    276   5-Me   0 Cl H      Br                                                    277   5-Me   0 Cl H      F                                                     278   5-Me   0 Cl H      SMe                                                   279   5-Me   0 Cl H      S(O)Me                                                280   5-Me   0 Cl H      CF.sub.3                                              281   5-Me   0 Cl H      CN                                                    282   5-Me   0 Cl Cl     Cl                                                    283   5-Me   0 Cl Cl     OMe                                                   284   5-Me   0 Cl Cl     SMe                                                   285   5-Me   0 Cl Cl     SO.sub.2 Me                                           286   5-Me   0 Cl Me     Cl                                                    287   5-Me   0 Cl Me     SO.sub.2 Me                                           288   5-Me   0 Cl OMe    Cl                                                    289   5-Me   0 Cl OMe    Br                                                    290   5-Me   0 Cl OMe    SO.sub.2 Me                                           291   5-Me   0 Cl OEt    Br                                                    292   5-Me   0 Br H      OMe                                                   293   5-Me   0 F  H      F                                                     294   5-Me   0 I  I      I                                                     295   5-Me   0 Me H      CN                                                    296   5-Me   0 Me H      Me                                                    297   5-Me   0 Me H      OMe                                                   298   5-Me   0 Me Cl     Cl                                                    299   5-Me   0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           300   5-Me   0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           301   5-Me   0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           302   5-Me   0 NO.sub.2                                                                          H      Cl                                                    303   5-Me   0 NO.sub.2                                                                          H      Br                                                    304   5-Me   0 NO.sub.2                                                                          H      F                                                     305   5-Me   0 NO.sub.2                                                                          H      CN                                                    306   5-Me   0 NO.sub.2                                                                          H      SMe                                                   307   5-Me   0 NO.sub.2                                                                          H      CF.sub.3                                              308   5-Me   0 NO.sub.2                                                                          OMe    Cl                                                    309   5-Me   0 NO.sub.2                                                                          OMe    CF.sub.3                                              310   5-Me   0 CF.sub.3                                                                          H      Cl                                                    311   5-Me   0 CF.sub.3                                                                          H      Br                                                    312   5-Me   0 CF.sub.3                                                                          H      SMe                                                   313   5-Me   0 CF.sub.3                                                                          H      CF.sub.3                                              314   5-Me   0 OMe                                                                               H      Cl                                                    315   5-Me   0 OMe                                                                               H      OMe                                                   316   5-Me   1 Cl H      Cl                                                    317   5-Me   1 Cl H      SO.sub.2 Me                                           318   5-Me   1 Cl H      NO.sub.2                                              319   5-Me   1 Cl H      OMe                                                   320   5-Me   1 Cl H      Me                                                    321   5-Me   1 Cl H      Br                                                    322   5-Me   1 Cl H      F                                                     323   5-Me   1 Cl H      SMe                                                   324   5-Me   1 Cl H      S(O)Me                                                325   5-Me   1 Cl H      CF.sub.3                                              326   5-Me   1 Cl H      CN                                                    327   5-Me   1 Cl Cl     Cl                                                    328   5-Me   1 Cl Cl     OMe                                                   329   5-Me   1 Cl Cl     SMe                                                   330   5-Me   1 Cl Cl     SO.sub.2 Me                                           331   5-Me   1 Cl Me     Cl                                                    332   5-Me   1 Cl Me     SO.sub.2 Me                                           333   5-Me   1 Cl OMe    Cl                                                    334   5-Me   1 Cl OMe    Br                                                    335   5-Me   1 Cl OMe    SO.sub.2 Me                                           336   5-Me   1 Cl OEt    Br                                                    337   5-Me   1 Br H      OMe                                                   338   5-Me   1 F  H      F                                                     339   5-Me   1 I  I      I                                                     340   5-Me   1 Me H      CN                                                    341   5-Me   1 Me H      Me                                                    342   5-Me   1 Me H      OMe                                                   343   5-Me   1 Me Cl     Cl                                                    344   5-Me   1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           345   5-Me   1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           346   5-Me   1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           347   5-Me   1 NO.sub.2                                                                          H      Cl                                                    348   5-Me   1 NO.sub.2                                                                          H      Br                                                    349   5-Me   1 NO.sub.2                                                                          H      F                                                     350   5-Me   1 NO.sub.2                                                                          H      CN                                                    351   5-Me   1 NO.sub.2                                                                          H      SMe                                                   352   5-Me   1 NO.sub.2                                                                          H      CF.sub.3                                              353   5-Me   1 NO.sub.2                                                                          OMe    Cl                                                    354   5-Me   1 NO.sub.2                                                                          OMe    CF.sub.3                                              355   5-Me   1 CF.sub.3                                                                          H      Cl                                                    356   5-Me   1 CF.sub.3                                                                          H      Br                                                    357   5-Me   1 CF.sub.3                                                                          H      SMe                                                   358   5-Me   1 CF.sub.3                                                                          H      CF.sub.3                                              359   5-Me   1 OMe                                                                               H      Cl                                                    360   5-Me   1 OMe                                                                               H      OMe                                                   361   5-Me   2 Cl H      Cl                                                    362   5-Me   2 Cl H      SO.sub.2 Me                                           363   5-Me   2 Cl H      NO.sub.2                                              364   5-Me   2 Cl H      OMe                                                   365   5-Me   2 Cl H      Me                                                    366   5-Me   2 Cl H      Br                                                    367   5-Me   2 Cl H      F                                                     368   5-Me   2 Cl H      SMe                                                   369   5-Me   2 Cl H      S(O)Me                                                370   5-Me   2 Cl H      CF.sub.3                                              371   5-Me   2 Cl H      CN                                                    372   5-Me   2 Cl Cl     Cl                                                    373   5-Me   2 Cl Cl     OMe                                                   374   5-Me   2 Cl Cl     SMe                                                   375   5-Me   2 Cl Cl     SO.sub.2 Me                                           376   5-Me   2 Cl Me     Cl                                                    377   5-Me   2 Cl Me     SO.sub.2 Me                                           378   5-Me   2 Cl OMe    Cl                                                    379   5-Me   2 Cl OMe    Br                                                    380   5-Me   2 Cl OMe    SO.sub.2 Me                                           381   5-Me   2 Cl OEt    Br                                                    382   5-Me   2 Br H      OMe                                                   383   5-Me   2 F  H      F                                                     384   5-Me   2 I  I      I                                                     385   5-Me   2 Me H      CN                                                    386   5-Me   2 Me H      Me                                                    387   5-Me   2 Me H      OMe                                                   388   5-Me   2 Me Cl     Cl                                                    389   5-Me   2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           390   5-Me   2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           391   5-Me   2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           392   5-Me   2 NO.sub.2                                                                          H      Cl                                                    393   5-Me   2 NO.sub.2                                                                          H      Br                                                    394   5-Me   2 NO.sub.2                                                                          H      F                                                     395   5-Me   2 NO.sub.2                                                                          H      CN                                                    396   5-Me   2 NO.sub.2                                                                          H      SMe                                                   397   5-Me   2 NO.sub.2                                                                          H      CF.sub.3                                              398   5-Me   2 NO.sub.2                                                                          OMe    Cl                                                    399   5-Me   2 NO.sub.2                                                                          OMe    CF.sub.3                                              400   5-Me   2 CF.sub.3                                                                          H      Cl                                                    401   5-Me   2 CF.sub.3                                                                          H      Br                                                    402   5-Me   2 CF.sub.3                                                                          H      SMe                                                   403   5-Me   2 CF.sub.3                                                                          H      CF.sub.3                                              404   5-Me   2 OMe                                                                               H      Cl                                                    405   5-Me   2 OMe                                                                               H      OMe                                                   406   6-Me   0 Cl H      Cl   Slightly green liquid                                                          n.sub.D.sup.20 1.6219                            407   6-Me   0 Cl H      SO.sub.2 Me                                           408   6-Me   0 Cl H      NO.sub.2                                              409   6-Me   0 Cl H      OMe                                                   410   6-Me   0 Cl H      Me                                                    411   6-Me   0 Cl H      Br                                                    412   6-Me   0 Cl H      F                                                     413   6-Me   0 Cl H      SMe                                                   414   6-Me   0 Cl H      S(O)Me                                                415   6-Me   0 Cl H      CF.sub.3                                              416   6-Me   0 Cl H      CN                                                    417   6-Me   0 Cl Cl     Cl                                                    418   6-Me   0 Cl Cl     OMe                                                   419   6-Me   0 Cl Cl     SMe                                                   420   6-Me   0 Cl Cl     SO.sub.2 Me                                           421   6-Me   0 Cl Me     Cl   Slightly yellow liquid                                                         n.sub.D.sup.20 1.6203                            422   6-Me   0 Cl Me     SO.sub.2 Me                                           423   6-Me   0 Cl OMe    Cl                                                    424   6-Me   0 Cl OMe    Br                                                    425   6-Me   0 Cl OMe    SO.sub.2 Me                                           426   6-Me   0 Cl OEt    Br                                                    427   6-Me   0 Br H      OMe                                                   428   6-Me   0 F  H      F                                                     429   6-Me   0 I  I      I                                                     430   6-Me   0 Me H      CN                                                    431   6-Me   0 Me H      Me                                                    432   6-Me   0 Me H      OMe                                                   433   6-Me   0 Me Cl     Cl                                                    434   6-Me   0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           435   6-Me   0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           436   6-Me   0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           437   6-Me   0 NO.sub.2                                                                          H      Cl                                                    438   6-Me   0 NO.sub.2                                                                          H      Br                                                    439   6-Me   0 NO.sub.2                                                                          H      F                                                     440   6-Me   0 NO.sub.2                                                                          H      CN                                                    441   6-Me   0 NO.sub.2                                                                          H      SMe                                                   442   6-Me   0 NO.sub.2                                                                          H      CF.sub.3                                                                            Slightly yellow crystal                                                        m.p. 88˜91° C.                      443   6-Me   0 NO.sub.2                                                                          OMe    Cl                                                    444   6-Me   0 NO.sub.2                                                                          OMe    CF.sub.3                                              445   6-Me   0 CF.sub.3                                                                          H      Cl   Br                                               447   6-Me   0 CF.sub.3                                                                          H      SMe                                                   448   6-Me   0 CF.sub.3                                                                          H      CF.sub.3                                              449   6-Me   0 OMe                                                                               H      Cl                                                    450   6-Me   0 OMe                                                                               H      OMe                                                   451   6-Me   1 Cl H      Cl                                                    452   6-Me   1 Cl H      SO.sub.2 Me                                           453   6-Me   1 Cl H      NO.sub.2                                              454   6-Me   1 Cl H      OMe                                                   455   6-Me   1 Cl H      Me                                                    456   6-Me   1 Cl H      Br                                                    457   6-Me   1 Cl H      F                                                     458   6-Me   1 Cl H      SMe                                                   459   6-Me   1 Cl H      S(O)Me                                                460   6-Me   1 Cl H      CF.sub.3                                              461   6-Me   1 Cl H      CN                                                    462   6-Me   1 Cl Cl     Cl                                                    463   6-Me   1 Cl Cl     OMe                                                   464   6-Me   1 Cl Cl     SMe                                                   465   6-Me   1 Cl Cl     SO.sub.2 Me                                           466   6-Me   1 Cl Me     Cl                                                    467   6-Me   1 Cl Me     SO.sub.2 Me                                           468   6-Me   1 Cl OMe    Cl                                                    469   6-Me   1 Cl OMe    Br                                                    470   6-Me   1 Cl OMe    SO.sub.2 Me                                           471   6-Me   1 Cl OEt    Br                                                    472   6-Me   1 Br H      OMe                                                   473   6-Me   1 F  H      F                                                     474   6-Me   1 I  I      I                                                     475   6-Me   1 Me H      CN                                                    476   6-Me   1 Me H      Me                                                    477   6-Me   1 Me H      OMe                                                   478   6-Me   1 Me Cl     Cl                                                    479   6-Me   1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           480   6-Me   1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           481   6-Me   1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           482   6-Me   1 NO.sub.2                                                                          H      Cl                                                    483   6-Me   1 NO.sub.2                                                                          H      Br                                                    484   6-Me   1 NO.sub.2                                                                          H      F                                                     485   6-Me   1 NO.sub.2                                                                          H      CN                                                    486   6-Me   1 NO.sub.2                                                                          H      SMe                                                   487   6-Me   1 NO.sub.2                                                                          H      CF.sub.3                                              488   6-Me   1 NO.sub.2                                                                          OMe    Cl                                                    489   6-Me   1 NO.sub.2                                                                          OMe    CF.sub.3                                              490   6-Me   1 CF.sub.3                                                                          H      Cl                                                    491   6-Me   1 CF.sub.3                                                                          H      Br                                                    492   6-Me   1 CF.sub.3                                                                          H      SMe                                                   493   6-Me   1 CF.sub.3                                                                          H      CF.sub.3                                              494   6-Me   1 OMe                                                                               H      Cl                                                    495   6-Me   1 OMe                                                                               H      OMe                                                   496   6-Me   2 Cl H      Cl                                                    497   6-Me   2 Cl H      SO.sub.2 Me                                           498   6-Me   2 Cl H      NO.sub.2                                              499   6-Me   2 Cl H      OMe                                                   500   6-Me   2 Cl H      Me                                                    501   6-Me   2 Cl H      Br                                                    502   6-Me   2 Cl H      F                                                     503   6-Me   2 Cl H      SMe                                                   504   6-Me   2 Cl H      S(O)Me                                                505   6-Me   2 Cl H      CF.sub.3                                              506   6-Me   2 Cl H      CN                                                    507   6-Me   2 Cl Cl     Cl                                                    508   6-Me   2 Cl Cl     OMe                                                   509   6-Me   2 Cl Cl     SMe                                                   510   6-Me   2 Cl Cl     SO.sub.2 Me                                           511   6-Me   2 Cl Me     Cl                                                    512   6-Me   2 Cl Me     SO.sub.2 Me                                           513   6-Me   2 Cl OMe    Cl                                                    514   6-Me   2 Cl OMe    Br                                                    515   6-Me   2 Cl OMe    SO.sub.2 Me                                           516   6-Me   2 Cl OEt    Br                                                    517   6-Me   2 Br H      OMe                                                   518   6-Me   2 F  H      F                                                     519   6-Me   2 I  I      I                                                     520   6-Me   2 Me H      CN                                                    521   6-Me   2 Me H      Me                                                    522   6-Me   2 Me H      OMe                                                   523   6-Me   2 Me Cl     Cl                                                    524   6-Me   2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           525   6-Me   2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           526   6-Me   2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           527   6-Me   2 NO.sub.2                                                                          H      Cl                                                    528   6-Me   2 NO.sub.2                                                                          H      Br                                                    529   6-Me   2 NO.sub.2                                                                          H      F                                                     530   6-Me   2 NO.sub.2                                                                          H      CN                                                    531   6-Me   2 NO.sub.2                                                                          H      SMe                                                   532   6-Me   2 NO.sub.2                                                                          H      CF.sub.3                                              533   6-Me   2 NO.sub.2                                                                          OMe    Cl                                                    534   6-Me   2 NO.sub.2                                                                          OMe    CF.sub.3                                              535   6-Me   2 CF.sub.3                                                                          H      Cl                                                    536   6-Me   2 CF.sub.3                                                                          H      Br                                                    537   6-Me   2 CF.sub.3                                                                          H      SMe                                                   538   6-Me   2 CF.sub.3                                                                          H      CF.sub.3                                              539   6-Me   2 OMe                                                                               H      Cl                                                    540   6-Me   2 OMe                                                                               H      OMe                                                   541   4.4-diMe                                                                              0 Cl H      Cl                                                    542   4.4-diMe                                                                              0 Cl H      SO.sub.2 Me                                           543   4.4-diMe                                                                              0 Cl H      NO.sub.2                                              544   4.4-diMe                                                                              0 Cl H      OMe                                                   545   4.4-diMe                                                                              0 Cl H      Me                                                    546   4.4-diMe                                                                              0 Cl H      Br                                                    547   4.4-diMe                                                                              0 Cl H      F                                                     548   4.4-diMe                                                                              0 Cl H      SMe                                                   549   4.4-diMe                                                                              0 Cl H      S(O)Me                                                550   4.4-diMe                                                                              0 Cl H      CF.sub.3                                              551   4.4-diMe                                                                              0 Cl H      CN                                                    552   4.4-diMe                                                                              0 Cl Cl     Cl                                                    553   4.4-diMe                                                                              0 Cl Cl     OMe                                                   554   4.4-diMe                                                                              0 Cl Cl     SMe                                                   555   4.4-diMe                                                                              0 Cl Cl     SO.sub.2 Me                                           556   4.4-diMe                                                                              0 Cl Me     Cl                                                    557   4.4-diMe                                                                              0 Cl Me     SO.sub.2 Me                                           558   4.4-diMe                                                                              0 Cl OMe    Cl                                                    559   4.4-diMe                                                                              0 Cl OMe    Br                                                    560   4.4-diMe                                                                              0 Cl OMe    SO.sub.2 Me                                           561   4.4-diMe                                                                              0 Cl OEt    Br                                                    562   4.4-diMe                                                                              0 Br H      OMe                                                   563   4.4-diMe                                                                              0 F  H      F                                                     564   4.4-diMe                                                                              0 I  I      I                                                     565   4.4-diMe                                                                              0 Me H      CN                                                    566   4.4-diMe                                                                              0 Me H      Me                                                    567   4.4-diMe                                                                              0 Me H      OMe                                                   568   4.4-diMe                                                                              0 Me Cl     Cl                                                    569   4.4-diMe                                                                              0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           570   4.4-diMe                                                                              0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           571   4.4-diMe                                                                              0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           572   4.4-diMe                                                                              0 NO.sub.2                                                                          H      Cl                                                    573   4.4-diMe                                                                              0 NO.sub.2                                                                          H      Br                                                    574   4.4-diMe                                                                              0 NO.sub.2                                                                          H      F                                                     575   4.4-diMe                                                                              0 NO.sub.2                                                                          H      CN                                                    576   4.4-diMe                                                                              0 NO.sub.2                                                                          H      SMe                                                   577   4.4-diMe                                                                              0 NO.sub.2                                                                          H      CF.sub.3                                              578   4.4-diMe                                                                              0 NO.sub.2                                                                          OMe    Cl                                                    579   4.4-diMe                                                                              0 NO.sub.2                                                                          OMe    CF.sub.3                                              580   4.4-diMe                                                                              0 CF.sub.3                                                                          H      Cl                                                    581   4.4-diMe                                                                              0 CF.sub.3                                                                          H      Br                                                    582   4.4-diMe                                                                              0 CF.sub.3                                                                          H      SMe                                                   583   4.4-diMe                                                                              0 CF.sub.3                                                                          H      CF.sub.3                                              584   4.4-diMe                                                                              0 OMe                                                                               H      Cl                                                    585   4.4-diMe                                                                              0 OMe                                                                               H      OMe                                                   586   4.4-diMe                                                                              1 Cl H      Cl                                                    587   4.4-diMe                                                                              1 Cl H      SO.sub.2 Me                                           588   4.4-diMe                                                                              1 Cl H      NO.sub.2                                              589   4.4-diMe                                                                              1 Cl H      OMe                                                   590   4.4-diMe                                                                              1 Cl H      Me                                                    591   4.4-diMe                                                                              1 Cl H      Br                                                    592   4.4-diMe                                                                              1 Cl H      F                                                     593   4.4-diMe                                                                              1 Cl H      SMe                                                   594   4.4-diMe                                                                              1 Cl H      S(O)Me                                                595   4.4-diMe                                                                              1 Cl H      CF.sub.3                                              596   4.4-diMe                                                                              1 Cl H      CN                                                    597   4.4-diMe                                                                              1 Cl Cl     Cl                                                    598   4.4-diMe                                                                              1 Cl Cl     OMe                                                   599   4.4-diMe                                                                              1 Cl Cl     SMe                                                   600   4.4-diMe                                                                              1 Cl Cl     SO.sub.2 Me                                           601   4.4-diMe                                                                              1 Cl Me     Cl                                                    602   4.4-diMe                                                                              1 Cl Me     SO.sub.2 Me                                           603   4.4-diMe                                                                              1 Cl OMe    Cl                                                    604   4.4-diMe                                                                              1 Cl OMe    Br                                                    605   4.4-diMe                                                                              1 Cl OMe    SO.sub.2 Me                                           606   4.4-diMe                                                                              1 Cl OEt    Br                                                    607   4.4-diMe                                                                              1 Br H      OMe                                                   608   4.4-diMe                                                                              1 F  H      F                                                     609   4.4-diMe                                                                              1 I  I      I                                                     610   4.4-diMe                                                                              1 Me H      CN                                                    611   4.4-diMe                                                                              1 Me H      Me                                                    612   4.4-diMe                                                                              1 Me H      OMe                                                   613   4.4-diMe                                                                              1 Me Cl     Cl                                                    614   4.4-diMe                                                                              1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           615   4.4-diMe                                                                              1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           616   4.4-diMe                                                                              1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           617   4.4-diMe                                                                              1 NO.sub.2                                                                          H      Cl                                                    618   4.4-diMe                                                                              1 NO.sub.2                                                                          H      Br                                                    619   4.4-diMe                                                                              1 NO.sub.2                                                                          H      F                                                     620   4.4-diMe                                                                              1 NO.sub.2                                                                          H      CN                                                    621   4.4-diMe                                                                              1 NO.sub.2                                                                          H      SMe                                                   622   4.4-diMe                                                                              1 NO.sub.2                                                                          H      CF.sub.3                                              623   4.4-diMe                                                                              1 NO.sub.2                                                                          OMe    Cl                                                    624   4.4-diMe                                                                              1 NO.sub.2                                                                          OMe    CF.sub.3                                              625   4.4-diMe                                                                              1 CF.sub.3                                                                          H      Cl                                                    626   4.4-diMe                                                                              1 CF.sub.3                                                                          H      Br                                                    627   4.4-diMe                                                                              1 CF.sub.3                                                                          H      SMe                                                   628   4.4-diMe                                                                              1 CF.sub.3                                                                          H      CF.sub.3                                              629   4.4-diMe                                                                              1 OMe                                                                               H      Cl                                                    630   4.4-diMe                                                                              1 OMe                                                                               H      OMe                                                   631   4.4-diMe                                                                              2 Cl H      Cl                                                    632   4.4-diMe                                                                              2 Cl H      SO.sub.2 Me                                           633   4.4-diMe                                                                              2 Cl H      NO.sub.2                                              634   4.4-diMe                                                                              2 Cl H      OMe                                                   635   4.4-diMe                                                                              2 Cl H      Me                                                    636   4.4-diMe                                                                              2 Cl H      Br                                                    637   4.4-diMe                                                                              2 Cl H      F                                                     638   4.4-diMe                                                                              2 Cl H      SMe                                                   639   4.4-diMe                                                                              2 Cl H      S(O)Me                                                640   4.4-diMe                                                                              2 Cl H      CF.sub.3                                              641   4.4-diMe                                                                              2 Cl H      CN                                                    642   4.4-diMe                                                                              2 Cl Cl     Cl                                                    643   4.4-diMe                                                                              2 Cl Cl     OMe                                                   644   4.4-diMe                                                                              2 Cl Cl     SMe                                                   645   4.4-diMe                                                                              2 Cl Cl     SO.sub.2 Me                                           646   4.4-diMe                                                                              2 Cl Me     Cl                                                    647   4.4-diMe                                                                              2 Cl Me     SO.sub.2 Me                                           648   4.4-diMe                                                                              2 Cl OMe    Cl                                                    649   4.4-diMe                                                                              2 Cl OMe    Br                                                    650   4.4-diMe                                                                              2 Cl OMe    SO.sub.2 Me                                           651   4.4-diMe                                                                              2 Cl OEt    Br                                                    652   4.4-diMe                                                                              2 Br H      OMe                                                   653   4.4-diMe                                                                              2 F  H      F                                                     654   4.4-diMe                                                                              2 I  I      I                                                     655   4.4-diMe                                                                              2 Me H      CN                                                    656   4.4-diMe                                                                              2 Me H      Me                                                    657   4.4-diMe                                                                              2 Me H      OMe                                                   658   4.4-diMe                                                                              2 Me Cl     Cl                                                    659   4.4-diMe                                                                              2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           660   4.4-diMe                                                                              2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           661   4.4-diMe                                                                              2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           662   4.4-diMe                                                                              2 NO.sub.2                                                                          H      Cl                                                    663   4.4-diMe                                                                              2 NO.sub.2                                                                          H      Br                                                    664   4.4-diMe                                                                              2 NO.sub.2                                                                          H      F                                                     665   4.4-diMe                                                                              2 NO.sub.2                                                                          H      CN                                                    666   4.4-diMe                                                                              2 NO.sub.2                                                                          H      SMe                                                   667   4.4-diMe                                                                              2 NO.sub.2                                                                          H      CF.sub.3                                              668   4.4-diMe                                                                              2 NO.sub.2                                                                          OMe    Cl                                                    669   4.4-diMe                                                                              2 NO.sub.2                                                                          OMe    CF.sub.3                                              670   4.4-diMe                                                                              2 CF.sub.3                                                                          H      Cl                                                    671   4.4-diMe                                                                              2 CF.sub.3                                                                          H      Br                                                    672   4.4-diMe                                                                              2 CF.sub.3                                                                          H      SMe                                                   673   4.4-diMe                                                                              2 CF.sub.3                                                                          H      CF.sub.3                                              674   4.4-diMe                                                                              2 OMe                                                                               H      Cl                                                    675   4.4-diMe                                                                              2 OMe                                                                               H      OMe                                                   676   5.5-diMe                                                                              0 Cl H      Cl                                                    677   5.5-diMe                                                                              0 Cl H      SO.sub.2 Me                                           678   5.5-diMe                                                                              0 Cl H      NO.sub.2                                              679   5.5-diMe                                                                              0 Cl H      OMe                                                   680   5.5-diMe                                                                              0 Cl H      Me                                                    681   5.5-diMe                                                                              0 Cl H      Br                                                    682   5.5-diMe                                                                              0 Cl H      F                                                     683   5.5-diMe                                                                              0 Cl H      SMe                                                   684   5.5-diMe                                                                              0 Cl H      S(O)Me                                                685   5.5-diMe                                                                              0 Cl H      CF.sub.3                                              686   5.5-diMe                                                                              0 Cl H      CN                                                    687   5.5-diMe                                                                              0 Cl Cl     Cl                                                    688   5.5-diMe                                                                              0 Cl Cl     OMe                                                   689   5.5-diMe                                                                              0 Cl Cl     SMe                                                   690   5.5-diMe                                                                              0 Cl Cl     SO.sub.2 Me                                           691   5.5-diMe                                                                              0 Cl Me     Cl                                                    692   5.5-diMe                                                                              0 Cl Me     SO.sub.2 Me                                           693   5.5-diMe                                                                              0 Cl OMe    Cl                                                    694   5.5-diMe                                                                              0 Cl OMe    Br                                                    695   5.5-diMe                                                                              0 Cl OMe    SO.sub.2 Me                                           696   5.5-diMe                                                                              0 Cl OEt    Br                                                    697   5.5-diMe                                                                              0 Br H      OMe                                                   698   5.5-diMe                                                                              0 F  H      F                                                     699   5.5-diMe                                                                              0 I  I      I                                                     700   5.5-diMe                                                                              0 Me H      CN                                                    701   5.5-diMe                                                                              0 Me H      Me                                                    702   5.5-diMe                                                                              0 Me H      OMe                                                   703   5.5-diMe                                                                              0 Me Cl     Cl                                                    704   5.5-diMe                                                                              0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           705   5.5-diMe                                                                              0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           706   5.5-diMe                                                                              0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           707   5.5-diMe                                                                              0 NO.sub.2                                                                          H      Cl                                                    708   5.5-diMe                                                                              0 NO.sub.2                                                                          H      Br                                                    709   5.5-diMe                                                                              0 NO.sub.2                                                                          H      F                                                     710   5.5-diMe                                                                              0 NO.sub.2                                                                          H      CN                                                    711   5.5-diMe                                                                              0 NO.sub.2                                                                          H      SMe                                                   712   5.5-diMe                                                                              0 NO.sub.2                                                                          H      CF.sub.3                                              713   5.5-diMe                                                                              0 NO.sub.2                                                                          OMe    Cl                                                    714   5.5-diMe                                                                              0 NO.sub.2                                                                          OMe    CF.sub.3                                              715   5.5-diMe                                                                              0 CF.sub.3                                                                          H      Cl                                                    716   5.5-diMe                                                                              0 CF.sub.3                                                                          H      Br                                                    717   5.5-diMe                                                                              0 CF.sub.3                                                                          H      SMe                                                   718   5.5-diMe                                                                              0 CF.sub.3                                                                          H      CF.sub.3                                              719   5.5-diMe                                                                              0 OMe                                                                               H      Cl                                                    720   5.5-diMe                                                                              0 OMe                                                                               H      OMe                                                   721   5.5-diMe                                                                              1 Cl H      Cl                                                    722   5.5-diMe                                                                              1 Cl H      SO.sub.2 Me                                           723   5.5-diMe                                                                              1 Cl H      NO.sub.2                                              724   5.5-diMe                                                                              1 Cl H      OMe                                                   725   5.5-diMe                                                                              1 Cl H      Me                                                    726   5.5-diMe                                                                              1 Cl H      Br                                                    727   5.5-diMe                                                                              1 Cl H      F                                                     728   5.5-diMe                                                                              1 Cl H      SMe                                                   729   5.5-diMe                                                                              1 Cl H      S(O)Me                                                730   5.5-diMe                                                                              1 Cl H      CF.sub.3                                              731   5.5-diMe                                                                              1 Cl H      CN                                                    732   5.5-diMe                                                                              1 Cl Cl     Cl                                                    733   5.5-diMe                                                                              1 Cl Cl     OMe                                                   734   5.5-diMe                                                                              1 Cl Cl     SMe                                                   735   5.5-diMe                                                                              1 Cl Cl     SO.sub.2 Me                                           736   5.5-diMe                                                                              1 Cl Me     Cl                                                    737   5.5-diMe                                                                              1 Cl Me     SO.sub.2 Me                                           738   5.5-diMe                                                                              1 Cl OMe    Cl                                                    739   5.5-diMe                                                                              1 Cl OMe    Br                                                    740   5.5-diMe                                                                              1 Cl OMe    SO.sub.2 Me                                           741   5.5-diMe                                                                              1 Cl OEt    Br                                                    742   5.5-diMe                                                                              1 Br H      OMe                                                   743   5.5-diMe                                                                              1 F  H      F                                                     744   5.5-diMe                                                                              1 I  I      I                                                     745   5.5-diMe                                                                              1 Me H      CN                                                    746   5.5-diMe                                                                              1 Me H      Me                                                    747   5.5-diMe                                                                              1 Me H      OMe                                                   748   5.5-diMe                                                                              1 Me Cl     Cl                                                    749   5.5-diMe                                                                              1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           750   5.5-diMe                                                                              1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           751   5.5-diMe                                                                              1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           752   5.5-diMe                                                                              1 NO.sub.2                                                                          H      Cl                                                    753   5.5-diMe                                                                              1 NO.sub.2                                                                          H      Br                                                    754   5.5-diMe                                                                              1 NO.sub.2                                                                          H      F                                                     755   5.5-diMe                                                                              1 NO.sub.2                                                                          H      CN                                                    756   5.5-diMe                                                                              1 NO.sub.2                                                                          H      SMe                                                   757   5.5-diMe                                                                              1 NO.sub.2                                                                          H      CF.sub.3                                              758   5.5-diMe                                                                              1 NO.sub.2                                                                          OMe    Cl                                                    759   5.5-diMe                                                                              1 NO.sub.2                                                                          OMe    CF.sub.3                                              760   5.5-diMe                                                                              1 CF.sub.3                                                                          H      Cl                                                    761   5.5-diMe                                                                              1 CF.sub.3                                                                          H      Br                                                    762   5.5-diMe                                                                              1 CF.sub.3                                                                          H      SMe                                                   763   5.5-diMe                                                                              1 CF.sub.3                                                                          H      CF.sub.3                                              764   5.5-diMe                                                                              1 OMe                                                                               H      Cl                                                    765   5.5-diMe                                                                              1 OMe                                                                               H      OMe                                                   766   5.5-diMe                                                                              2 Cl H      Cl                                                    767   5.5-diMe                                                                              2 Cl H      SO.sub.2 Me                                           768   5.5-diMe                                                                              2 Cl H      NO.sub.2                                              769   5.5-diMe                                                                              2 Cl H      OMe                                                   770   5.5-diMe                                                                              2 Cl H      Me                                                    771   5.5-diMe                                                                              2 Cl H      Br                                                    772   5.5-diMe                                                                              2 Cl H      F                                                     773   5.5-diMe                                                                              2 Cl H      SMe                                                   774   5.5-diMe                                                                              2 Cl H      S(O)Me                                                775   5.5-diMe                                                                              2 Cl H      CF.sub.3                                              776   5.5-diMe                                                                              2 Cl H      CN                                                    777   5.5-diMe                                                                              2 Cl Cl     Cl                                                    778   5.5-diMe                                                                              2 Cl Cl     OMe                                                   779   5.5-diMe                                                                              2 Cl Cl     SMe                                                   780   5.5-diMe                                                                              2 Cl Cl     SO.sub.2 Me                                           781   5.5-diMe                                                                              2 Cl Me     Cl                                                    782   5.5-diMe                                                                              2 Cl Me     SO.sub.2 Me                                           783   5.5-diMe                                                                              2 Cl OMe    Cl                                                    784   5.5-diMe                                                                              2 Cl OMe    Br                                                    785   5.5-diMe                                                                              2 Cl OMe    SO.sub.2 Me                                           786   5.5-diMe                                                                              2 Cl OEt    Br                                                    787   5.5-diMe                                                                              2 Br H      OMe                                                   788   5.5-diMe                                                                              2 F  H      F                                                     789   5.5-diMe                                                                              2 I  I      I                                                     790   5.5-diMe                                                                              2 Me H      CN                                                    791   5.5-diMe                                                                              2 Me H      Me                                                    792   5.5-diMe                                                                              2 Me H      OMe                                                   793   5.5-diMe                                                                              2 Me Cl     Cl                                                    794   5.5-diMe                                                                              2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           795   5.5-diMe                                                                              2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           796   5.5-diMe                                                                              2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           797   5.5-diMe                                                                              2 NO.sub.2                                                                          H      Cl                                                    798   5.5-diMe                                                                              2 NO.sub.2                                                                          H      Br                                                    799   5.5-diMe                                                                              2 NO.sub.2                                                                          H      F                                                     800   5.5-diMe                                                                              2 NO.sub.2                                                                          H      CN                                                    801   5.5-diMe                                                                              2 NO.sub.2                                                                          H      SMe                                                   802   5.5-diMe                                                                              2 NO.sub.2                                                                          H      CF.sub.3                                              803   5.5-diMe                                                                              2 NO.sub.2                                                                          OMe    Cl                                                    804   5.5-diMe                                                                              2 NO.sub.2                                                                          OMe    CF.sub.3                                              805   5.5-diMe                                                                              2 CF.sub.3                                                                          H      Cl                                                    806   5.5-diMe                                                                              2 CF.sub.3                                                                          H      Br                                                    807   5.5-diMe                                                                              2 CF.sub.3                                                                          H      SMe                                                   808   5.5-diMe                                                                              2 CF.sub.3                                                                          H      CF.sub.3                                              809   5.5-diMe                                                                              2 OMe                                                                               H      Cl                                                    810   5.5-diMe                                                                              2 OMe                                                                               H      OMe                                                   811   6.6-diMe                                                                              0 Cl H      Cl                                                    812   6.6-diMe                                                                              0 Cl H      SO.sub.2 Me                                           813   6.6-diMe                                                                              0 Cl H      NO.sub.2                                              814   6.6-diMe                                                                              0 Cl H      OMe                                                   815   6.6-diMe                                                                              0 Cl H      Me                                                    816   6.6-diMe                                                                              0 Cl H      Br                                                    817   6.6-diMe                                                                              0 Cl H      F                                                     818   6.6-diMe                                                                              0 Cl H      SMe                                                   819   6.6-diMe                                                                              0 Cl H      S(O)Me                                                820   6.6-diMe                                                                              0 Cl H      CF.sub.3                                              821   6.6-diMe                                                                              0 Cl H      CN                                                    822   6.6-diMe                                                                              0 Cl Cl     Cl                                                    823   6.6-diMe                                                                              0 Cl Cl     OMe                                                   824   6.6-diMe                                                                              0 Cl Cl     SMe                                                   825   6.6-diMe                                                                              0 Cl Cl     SO.sub. 2 Me                                          826   6.6-diMe                                                                              0 Cl Me     Cl                                                    827   6.6-diMe                                                                              0 Cl Me     SO.sub.2 Me                                           828   6.6-diMe                                                                              0 Cl OMe    Cl                                                    829   6.6-diMe                                                                              0 Cl OMe    Br                                                    830   6.6-diMe                                                                              0 Cl OMe    SO.sub.2 Me                                           831   6.6-diMe                                                                              0 Cl OEt    Br                                                    832   6.6-diMe                                                                              0 Br H      OMe                                                   833   6.6-diMe                                                                              0 F  H      F                                                     834   6.6-diMe                                                                              0 I  I      I                                                     835   6.6-diMe                                                                              0 Me H      CN                                                    836   6.6-diMe                                                                              0 Me H      Me                                                    837   6.6-diMe                                                                              0 Me H      OMe                                                   838   6.6-diMe                                                                              0 Me Cl     Cl                                                    839   6.6-diMe                                                                              0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           840   6.6-diMe                                                                              0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           841   6.6-diMe                                                                              0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           842   6.6-diMe                                                                              0 NO.sub.2                                                                          H      Cl                                                    843   6.6-diMe                                                                              0 NO.sub.2                                                                          H      Br                                                    844   6.6-diMe                                                                              0 NO.sub.2                                                                          H      F                                                     845   6.6-diMe                                                                              0 NO.sub.2                                                                          H      CN                                                    846   6.6-diMe                                                                              0 NO.sub.2                                                                          H      SMe                                                   847   6.6-diMe                                                                              0 NO.sub.2                                                                          H      CF.sub.3                                              848   6.6-diMe                                                                              0 NO.sub.2                                                                          OMe    Cl                                                    849   6.6-diMe                                                                              0 NO.sub.2                                                                          OMe    CF.sub.3                                              850   6.6-diMe                                                                              0 CF.sub.3                                                                          H      Cl                                                    851   6.6-diMe                                                                              0 CF.sub.3                                                                          H      Br                                                    852   6.6-diMe                                                                              0 CF.sub.3                                                                          H      SMe                                                   853   6.6-diMe                                                                              0 CF.sub.3                                                                          H      CF.sub.3                                              854   6.6-diMe                                                                              0 OMe                                                                               H      Cl                                                    855   6.6-diMe                                                                              0 OMe                                                                               H      OMe                                                   856   6.6-diMe                                                                              1 Cl H      Cl                                                    857   6.6-diMe                                                                              1 Cl H      SO.sub.2 Me                                           858   6.6-diMe                                                                              1 Cl H      NO.sub.2                                              859   6.6-diMe                                                                              1 Cl H      OMe                                                   860   6.6-diMe                                                                              1 Cl H      Me                                                    861   6.6-diMe                                                                              1 Cl H      Br                                                    862   6.6-diMe                                                                              1 Cl H      F                                                     863   6.6-diMe                                                                              1 Cl H      SMe                                                   864   6.6-diMe                                                                              1 Cl H      S(O)Me                                                865   6.6-diMe                                                                              1 Cl H      CF.sub.3                                              866   6.6-diMe                                                                              1 Cl H      CN                                                    867   6.6-diMe                                                                              1 Cl Cl     Cl                                                    868   6.6-diMe                                                                              1 Cl Cl     OMe                                                   869   6.6-diMe                                                                              1 Cl Cl     SMe                                                   870   6.6-diMe                                                                              1 Cl Cl     SO.sub.2 Me                                           871   6.6-diMe                                                                              1 Cl Me     Cl                                                    872   6.6-diMe                                                                              1 Cl Me     SO.sub.2 Me                                           873   6.6-diMe                                                                              1 Cl OMe    Cl                                                    874   6.6-diMe                                                                              1 Cl OMe    Br                                                    875   6.6-diMe                                                                              1 Cl OMe    SO.sub.2 Me                                           876   6.6-diMe                                                                              1 Cl OEt    Br                                                    877   6.6-diMe                                                                              1 Br H      OMe                                                   878   6.6-diMe                                                                              1 F  H      F                                                     879   6.6-diMe                                                                              1 I  I      I                                                     880   6.6-diMe                                                                              1 Me H      CN                                                    881   6.6-diMe                                                                              1 Me H      Me                                                    882   6.6-diMe                                                                              1 Me H      OMe                                                   883   6.6-diMe                                                                              1 Me Cl     Cl                                                    884   6.6-diMe                                                                              1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           885   6.6-diMe                                                                              1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           886   6.6-diMe                                                                              1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           887   6.6-diMe                                                                              1 NO.sub.2                                                                          H      Cl                                                    888   6.6-diMe                                                                              1 NO.sub.2                                                                          H      Br                                                    889   6.6-diMe                                                                              1 NO.sub.2                                                                          H      F                                                     890   6.6-diMe                                                                              1 NO.sub.2                                                                          H      CN                                                    891   6.6-diMe                                                                              1 NO.sub.2                                                                          H      SMe                                                   892   6.6-diMe                                                                              1 NO.sub.2                                                                          H      CF.sub.3                                              893   6.6-diMe                                                                              1 NO.sub.2                                                                          OMe    Cl                                                    894   6.6-diMe                                                                              1 NO.sub.2                                                                          OMe    CF.sub.3                                              895   6.6-diMe                                                                              1 CF.sub.3                                                                          H      Cl                                                    896   6.6-diMe                                                                              1 CF.sub.3                                                                          H      Br                                                    897   6.6-diMe                                                                              1 CF.sub.3                                                                          H      SMe                                                   898   6.6-diMe                                                                              1 CF.sub.3                                                                          H      CF.sub.3                                              899   6.6-diMe                                                                              1 OMe                                                                               H      Cl                                                    900   6.6-diMe                                                                              1 OMe                                                                               H      OMe                                                   901   6.6-diMe                                                                              2 Cl H      Cl                                                    902   6.6-diMe                                                                              2 Cl H      SO.sub.2 Me                                           903   6.6-diMe                                                                              2 Cl H      NO.sub.2                                              904   6.6-diMe                                                                              2 Cl H      OMe                                                   905   6.6-diMe                                                                              2 Cl H      Me                                                    906   6.6-diMe                                                                              2 Cl H      Br                                                    907   6.6-diMe                                                                              2 Cl H      F                                                     908   6.6-diMe                                                                              2 Cl H      SMe                                                   909   6.6-diMe                                                                              2 Cl H      S(O)Me                                                910   6.6-diMe                                                                              2 Cl H      CF.sub.3                                              911   6.6-diMe                                                                              2 Cl H      CN                                                    912   6.6-diMe                                                                              2 Cl Cl     Cl                                                    913   6.6-diMe                                                                              2 Cl Cl     OMe                                                   914   6.6-diMe                                                                              2 Cl Cl     SMe                                                   915   6.6-diMe                                                                              2 Cl Cl     SO.sub.2 Me                                           916   6.6-diMe                                                                              2 Cl Me     Cl                                                    917   6.6-diMe                                                                              2 Cl Me     SO.sub.2 Me                                           918   6.6-diMe                                                                              2 Cl OMe    Cl                                                    919   6.6-diMe                                                                              2 Cl OMe    Br                                                    920   6.6-diMe                                                                              2 Cl OMe    SO.sub.2 Me                                           921   6.6-diMe                                                                              2 Cl OEt    Br                                                    922   6.6-diMe                                                                              2 Br H      OMe                                                   923   6.6-diMe                                                                              2 F  H      F                                                     924   6.6-diMe                                                                              2 I  I      I                                                     925   6.6-diMe                                                                              2 Me H      CN                                                    926   6.6-diMe                                                                              2 Me H      Me                                                    927   6.6-diMe                                                                              2 Me H      OMe                                                   928   6.6-diMe                                                                              2 Me Cl     Cl                                                    929   6.6-diMe                                                                              2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           930   6.6-diMe                                                                              2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           931   6.6-diMe                                                                              2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           932   6.6-diMe                                                                              2 NO.sub.2                                                                          H      Cl                                                    933   6.6-diMe                                                                              2 NO.sub.2                                                                          H      Br                                                    934   6.6-diMe                                                                              2 NO.sub.2                                                                          H      F                                                     935   6.6-diMe                                                                              2 NO.sub.2                                                                          H      CN                                                    936   6.6-diMe                                                                              2 NO.sub.2                                                                          H      SMe                                                   937   6.6-diMe                                                                              2 NO.sub.2                                                                          H      CF.sub.3                                              938   6.6-diMe                                                                              2 NO.sub.2                                                                          OMe    Cl                                                    939   6.6-diMe                                                                              2 NO.sub.2                                                                          OMe    CF.sub.3                                              940   6.6-diMe                                                                              2 CF.sub.3                                                                          H      Cl                                                    941   6.6-diMe                                                                              2 CF.sub.3                                                                          H      Br                                                    942   6.6-diMe                                                                              2 CF.sub.3                                                                          H      SMe                                                   943   6.6-diMe                                                                              2 CF.sub.3                                                                          H      CF.sub.3                                              944   6.6-diMe                                                                              2 OMe                                                                               H      Cl                                                    945   6.6-diMe                                                                              2 OMe                                                                               H      OMe                                                   946   4-Ph   0 Cl H      Cl                                                    947   4-Ph   0 Cl H      SO.sub.2 Me                                           948   4-Ph   0 Cl H      NO.sub.2                                              949   4-Ph   0 Cl H      OMe                                                   950   4-Ph   0 Cl H      Me                                                    951   4-Ph   0 Cl H      Br                                                    952   4-Ph   0 Cl H      F                                                     953   4-Ph   0 Cl H      SMe                                                   954   4-Ph   0 Cl H      S(O)Me                                                955   4-Ph   0 Cl H      CF.sub.3                                              956   4-Ph   0 Cl H      CN                                                    957   4-Ph   0 Cl Cl     Cl                                                    958   4-Ph   0 Cl Cl     OMe                                                   959   4-Ph   0 Cl Cl     SMe                                                   960   4-Ph   0 Cl Cl     SO.sub.2 Me                                           961   4-Ph   0 Cl Me     Cl                                                    962   4-Ph   0 Cl Me     SO.sub.2 Me                                           963   4-Ph   0 Cl OMe    Cl                                                    964   4-Ph   0 Cl OMe    Br                                                    965   4-Ph   0 Cl OMe    SO.sub.2 Me                                           966   4-Ph   0 Cl OEt    Br                                                    967   4-Ph   0 Br H      OMe                                                   968   4-Ph   0 F  H      F                                                     969   4-Ph   0 I  I      I                                                     970   4-Ph   0 Me H      CN                                                    971   4-Ph   0 Me H      Me                                                    972   4-Ph   0 Me H      OMe                                                   973   4-Ph   0 Me Cl     Cl                                                    974   4-Ph   0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           975   4-Ph   0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           976   4-Ph   0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           977   4-Ph   0 NO.sub.2                                                                          H      Cl                                                    978   4-Ph   0 NO.sub.2                                                                          H      Br                                                    979   4-Ph   0 NO.sub.2                                                                          H      F                                                     980   4-Ph   0 NO.sub.2                                                                          H      CN                                                    981   4-Ph   0 NO.sub.2                                                                          H      SMe                                                   982   4-Ph   0 NO.sub.2                                                                          H      CF.sub.3                                              983   4-Ph   0 NO.sub.2                                                                          OMe    Cl                                                    984   4-Ph   0 NO.sub.2                                                                          OMe    CF.sub.3                                              985   4-Ph   0 CF.sub.3                                                                          H      Cl                                                    986   4-Ph   0 CF.sub.3                                                                          H      Br                                                    987   4-Ph   0 CF.sub.3                                                                          H      SMe                                                   988   4-Ph   0 CF.sub.3                                                                          H      CF.sub.3                                              989   4-Ph   0 OMe                                                                               H      Cl                                                    990   4-Ph   0 OMe                                                                               H      OMe                                                   991   4-Ph   1 Cl H      Cl                                                    992   4-Ph   1 Cl H      SO.sub.2 Me                                           993   4-Ph   1 Cl H      NO.sub.2                                              994   4-Ph   1 Cl H      OMe                                                   995   4-Ph   1 Cl H      Me                                                    996   4-Ph   1 Cl H      Br                                                    997   4-Ph   1 Cl H      F                                                     998   4-Ph   1 Cl H      SMe                                                   999   4-Ph   1 Cl H      S(O)Me                                                1000  4-Ph   1 Cl H      CF.sub.3                                              1001  4-Ph   1 Cl H      CN                                                    1002  4-Ph   1 Cl Cl     Cl                                                    1003  4-Ph   1 Cl Cl     OMe                                                   1004  4-Ph   1 Cl Cl     SMe                                                   1005  4-Ph   1 Cl Cl     SO.sub.2 Me                                           1006  4-Ph   1 Cl Me     Cl                                                    1007  4-Ph   1 Cl Me     SO.sub.2 Me                                           1008  4-Ph   1 Cl OMe    Cl                                                    1009  4-Ph   1 Cl OMe    Br                                                    1010  4-Ph   1 Cl OMe    SO.sub.2 Me                                           1011  4-Ph   1 Cl OEt    Br                                                    1012  4-Ph   1 Br H      OMe                                                   1013  4-Ph   1 F  H      F                                                     1014  4-Ph   1 I  I      I                                                     1015  4-Ph   1 Me H      CN                                                    1016  4-Ph   1 Me H      Me                                                    1017  4-Ph   1 Me H      OMe                                                   1018  4-Ph   1 Me Cl     Cl                                                    1019  4-Ph   1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           1020  4-Ph   1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           1021  4-Ph   1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           1022  4-Ph   1 NO.sub.2                                                                          H      Cl                                                    1023  4-Ph   1 NO.sub.2                                                                          H      Br                                                    1024  4-Ph   1 NO.sub.2                                                                          H      F                                                     1025  4-Ph   1 NO.sub.2                                                                          H      CN                                                    1026  4-Ph   1 NO.sub.2                                                                          H      SMe                                                   1027  4-Ph   1 NO.sub.2                                                                          H      CF.sub.3                                              1028  4-Ph   1 NO.sub.2                                                                          OMe    Cl                                                    1029  4-Ph   1 NO.sub.2                                                                          OMe    CF.sub.3                                              1030  4-Ph   1 CF.sub.3                                                                          H      Cl                                                    1031  4-Ph   1 CF.sub.3                                                                          H      Br                                                    1032  4-Ph   1 CF.sub.3                                                                          H      SMe                                                   1033  4-Ph   1 CF.sub.3                                                                          H      CF.sub.3                                              1034  4-Ph   1 OMe                                                                               H      Cl                                                    1035  4-Ph   1 OMe                                                                               H      OMe                                                   1036  4-Ph   2 Cl H      Cl                                                    1037  4-Ph   2 Cl H      SO.sub.2 Me                                           1038  4-Ph   2 Cl H      NO.sub.2                                              1039  4-Ph   2 Cl H      OMe                                                   1040  4-Ph   2 Cl H      Me                                                    1041  4-Ph   2 Cl H      Br                                                    1042  4-Ph   2 Cl H      F                                                     1043  4-Ph   2 Cl H      SMe                                                   1044  4-Ph   2 Cl H      S(O)Me                                                1045  4-Ph   2 Cl H      CF.sub.3                                              1046  4-Ph   2 Cl H      CN                                                    1047  4-Ph   2 Cl Cl     Cl                                                    1048  4-Ph   2 Cl Cl     OMe                                                   1049  4-Ph   2 Cl Cl     SMe                                                   1050  4-Ph   2 Cl Cl     SO.sub.2 Me                                           1051  4-Ph   2 Cl Me     Cl                                                    1052  4-Ph   2 Cl Me     SO.sub.2 Me                                           1053  4-Ph   2 Cl OMe    Cl                                                    1054  4-Ph   2 Cl OMe    Br                                                    1055  4-Ph   2 Cl OMe    SO.sub.2 Me                                           1056  4-Ph   2 Cl OEt    Br                                                    1057  4-Ph   2 Br H      OMe                                                   1058  4-Ph   2 F  H      F                                                     1059  4-Ph   2 I  I      I                                                     1060  4-Ph   2 Me H      CN                                                    1061  4-Ph   2 Me H      Me                                                    1062  4-Ph   2 Me H      OMe                                                   1063  4-Ph   2 Me Cl     Cl                                                    1064  4-Ph   2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           1065  4-Ph   2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           1066  4-Ph   2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           1067  4-Ph   2 NO.sub.2                                                                          H      Cl                                                    1068  4-Ph   2 NO.sub.2                                                                          H      Br                                                    1069  4-Ph   2 NO.sub.2                                                                          H      F                                                     1070  4-Ph   2 NO.sub.2                                                                          H      CN                                                    1071  4-Ph   2 NO.sub.2                                                                          H      SMe                                                   1072  4-Ph   2 NO.sub.2                                                                          H      CF.sub.3                                              1073  4-Ph   2 NO.sub.2                                                                          OMe    Cl                                                    1074  4-Ph   2 NO.sub.2                                                                          OMe    CF.sub.3                                              1075  4-Ph   2 CF.sub.3                                                                          H      Cl                                                    1076  4-Ph   2 CF.sub.3                                                                          H      Br                                                    1077  4-Ph   2 CF.sub.3                                                                          H      SMe                                                   1078  4-Ph   2 CF.sub.3                                                                          H      CF.sub.3                                              1079  4-Ph   2 OMe                                                                               H      Cl                                                    1080  4-Ph   2 OMe                                                                               H      OMe                                                   1081  5-Ph   0 Cl H      Cl                                                    1082  5-Ph   0 Cl H      SO.sub.2 Me                                           1083  5-Ph   0 Cl H      NO.sub.2                                              1084  5-Ph   0 Cl H      OMe                                                   1085  5-Ph   0 Cl H      Me                                                    1086  5-Ph   0 Cl H      Br                                                    1087  5-Ph   0 Cl H      F                                                     1088  5-Ph   0 Cl H      SMe                                                   1089  5-Ph   0 Cl H      S(O)Me                                                1090  5-Ph   0 Cl H      CF.sub.3                                              1091  5-Ph   0 Cl H      CN                                                    1092  5-Ph   0 Cl Cl     Cl                                                    1093  5-Ph   0 Cl Cl     OMe                                                   1094  5-Ph   0 Cl Cl     SMe                                                   1095  5-Ph   0 Cl Cl     SO.sub.2 Me                                           1096  5-Ph   0 Cl Me     Cl                                                    1097  5-Ph   0 Cl Me     SO.sub.2 Me                                           1098  5-Ph   0 Cl OMe    Cl                                                    1099  5-Ph   0 Cl OMe    Br                                                    1100  5-Ph   0 Cl OMe    SO.sub.2 Me                                           1101  5-Ph   0 Cl OEt    Br                                                    1102  5-Ph   0 Br H      OMe                                                   1103  5-Ph   0 F  H      F                                                     1104  5-Ph   0 I  I      I                                                     1105  5-Ph   0 Me H      CN                                                    1106  5-Ph   0 Me H      Me                                                    1107  5-Ph   0 Me H      OMe                                                   1108  5-Ph   0 Me Cl     Cl                                                    1109  5-Ph   0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           1110  5-Ph   0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           1111  5-Ph   0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           1112  5-Ph   0 NO.sub.2                                                                          H      Cl                                                    1113  5-Ph   0 NO.sub.2                                                                          H      Br                                                    1114  5-Ph   0 NO.sub.2                                                                          H      F                                                     1115  5-Ph   0 NO.sub.2                                                                          H      CN                                                    1116  5-Ph   0 NO.sub.2                                                                          H      SMe                                                   1117  5-Ph   0 NO.sub.2                                                                          H      CF.sub.3                                              1118  5-Ph   0 NO.sub.2                                                                          OMe    Cl                                                    1119  5-Ph   0 NO.sub.2                                                                          OMe    CF.sub.3                                              1120  5-Ph   0 CF.sub.3                                                                          H      Cl                                                    1121  5-Ph   0 CF.sub.3                                                                          H      Br                                                    1122  5-Ph   0 CF.sub.3                                                                          H      SMe                                                   1123  5-Ph   0 CF.sub.3                                                                          H      CF.sub.3                                              1124  5-Ph   0 OMe                                                                               H      Cl                                                    1125  5-Ph   0 OMe                                                                               H      OMe                                                   1126  5-Ph   1 Cl H      Cl                                                    1127  5-Ph   1 Cl H      SO.sub.2 Me                                           1128  5-Ph   1 Cl H      NO.sub.2                                              1129  5-Ph   1 Cl H      OMe                                                   1130  5-Ph   1 Cl H      Me                                                    1131  5-Ph   1 Cl H      Br                                                    1132  5-Ph   1 Cl H      F                                                     1133  5-Ph   1 Cl H      SMe                                                   1134  5-Ph   1 Cl H      S(O)Me                                                1135  5-Ph   1 Cl H      CF.sub.3                                              1136  5-Ph   1 Cl H      CN                                                    1137  5-Ph   1 Cl Cl     Cl                                                    1138  5-Ph   1 Cl Cl     OMe                                                   1139  5-Ph   1 Cl Cl     SMe                                                   1140  5-Ph   1 Cl Cl     SO.sub.2 Me                                           1141  5-Ph   1 Cl Me     Cl                                                    1142  5-Ph   1 Cl Me     SO.sub.2 Me                                           1143  5-Ph   1 Cl OMe    Cl                                                    1144  5-Ph   1 Cl OMe    Br                                                    1145  5-Ph   1 Cl OMe    SO.sub.2 Me                                           1146  5-Ph   1 Cl OEt    Br                                                    1147  5-Ph   1 Br H      OMe                                                   1148  5-Ph   1 F  H      F                                                     1149  5-Ph   1 I  I      I                                                     1150  5-Ph   1 Me H      CN                                                    1151  5-Ph   1 Me H      Me                                                    1152  5-Ph   1 Me H      OMe                                                   1153  5-Ph   1 Me Cl     Cl                                                    1154  5-Ph   1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           1155  5-Ph   1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           1156  5-Ph   1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           1157  5-Ph   1 NO.sub.2                                                                          H      Cl                                                    1158  5-Ph   1 NO.sub.2                                                                          H      Br                                                    1159  5-Ph   1 NO.sub.2                                                                          H      F                                                     1160  5-Ph   1 NO.sub.2                                                                          H      CN                                                    1161  5-Ph   1 NO.sub.2                                                                          H      SMe                                                   1162  5-Ph   1 NO.sub.2                                                                          H      CF.sub.3                                              1163  5-Ph   1 NO.sub.2                                                                          OMe    Cl                                                    1164  5-Ph   1 NO.sub.2                                                                          OMe    CF.sub.3                                              1165  5-Ph   1 CF.sub.3                                                                          H      Cl                                                    1166  5-Ph   1 CF.sub.3                                                                          H      Br                                                    1167  5-Ph   1 CF.sub.3                                                                          H      SMe                                                   1168  5-Ph   1 CF.sub.3                                                                          H      CF.sub.3                                              1169  5-Ph   1 OMe                                                                               H      Cl                                                    1170  5-Ph   1 OMe                                                                               H      OMe                                                   1171  5-Ph   2 Cl H      Cl                                                    1172  5-Ph   2 Cl H      SO.sub.2 Me                                           1173  5-Ph   2 Cl H      NO.sub.2                                              1174  5-Ph   2 Cl H      OMe                                                   1175  5-Ph   2 Cl H      Me                                                    1176  5-Ph   2 Cl H      Br                                                    1177  5-Ph   2 Cl H      F                                                     1178  5-Ph   2 Cl H      SMe                                                   1179  5-Ph   2 Cl H      S(O)Me                                                1180  5-Ph   2 Cl H      CF.sub.3                                              1181  5-Ph   2 Cl H      CN                                                    1182  5-Ph   2 Cl Cl     Cl                                                    1183  5-Ph   2 Cl Cl     OMe                                                   1184  5-Ph   2 Cl Cl     SMe                                                   1185  5-Ph   2 Cl Cl     SO.sub.2 Me                                           1186  5-Ph   2 Cl Me     Cl                                                    1187  5-Ph   2 Cl Me     SO.sub.2 Me                                           1188  5-Ph   2 Cl OMe    Cl                                                    1189  5-Ph   2 Cl OMe    Br                                                    1190  5-Ph   2 Cl OMe    SO.sub.2 Me                                           1191  5-Ph   2 Cl OEt    Br                                                    1192  5-Ph   2 Br H      OMe                                                   1193  5-Ph   2 F  H      F                                                     1194  5-Ph   2 I  I      I                                                     1195  5-Ph   2 Me H      CN                                                    1196  5-Ph   2 Me H      Me                                                    1197  5-Ph   2 Me H      OMe                                                   1198  5-Ph   2 Me Cl     Cl                                                    1199  5-Ph   2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           1200  5-Ph   2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           1201  5-Ph   2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           1202  5-Ph   2 NO.sub.2                                                                          H      Cl                                                    1203  5-Ph   2 NO.sub.2                                                                          H      Br                                                    1204  5-Ph   2 NO.sub.2                                                                          H      F                                                     1205  5-Ph   2 NO.sub.2                                                                          H      CN                                                    1206  5-Ph   2 NO.sub.2                                                                          H      SMe                                                   1207  5-Ph   2 NO.sub.2                                                                          H      CF.sub.3                                              1208  5-Ph   2 NO.sub.2                                                                          OMe    Cl                                                    1209  5-Ph   2 NO.sub.2                                                                          OMe    CF.sub.3                                              1210  5-Ph   2 CF.sub.3                                                                          H      Cl                                                    1211  5-Ph   2 CF.sub.3                                                                          H      Br                                                    1212  5-Ph   2 CF.sub.3                                                                          H      SMe                                                   1213  5-Ph   2 CF.sub.3                                                                          H      CF.sub.3                                              1214  5-Ph   2 OMe                                                                               H      Cl                                                    1215  5-Ph   2 OMe                                                                               H      OMe                                                   1216  6-Ph   0 Cl H      Cl                                                    1217  6-Ph   0 Cl H      SO.sub.2 Me                                           1218  6-Ph   0 Cl H      NO.sub.2                                              1219  6-Ph   0 Cl H      OMe                                                   1220  6-Ph   0 Cl H      Me                                                    1221  6-Ph   0 Cl H      Br                                                    1222  6-Ph   0 Cl H      F                                                     1223  6-Ph   0 Cl H      SMe                                                   1224  6-Ph   0 Cl H      S(O)Me                                                1225  6-Ph   0 Cl H      CF.sub.3                                              1226  6-Ph   0 Cl H      CN                                                    1227  6-Ph   0 Cl Cl     Cl                                                    1228  6-Ph   0 Cl Cl     OMe                                                   1229  6-Ph   0 Cl Cl     SMe                                                   1230  6-Ph   0 Cl Cl     SO.sub.2 Me                                           1231  6-Ph   0 Cl Me     Cl                                                    1232  6-Ph   0 Cl Me     SO.sub.2 Me                                           1233  6-Ph   0 Cl OMe    Cl                                                    1234  6-Ph   0 Cl OMe    Br                                                    1235  6-Ph   0 Cl OMe    SO.sub.2 Me                                           1236  6-Ph   0 Cl OEt    Br                                                    1237  6-Ph   0 Br H      OMe                                                   1238  6-Ph   0 F  H      F                                                     1239  6-Ph   0 I  I      I                                                     1240  6-Ph   0 Me H      CN                                                    1241  6-Ph   0 Me H      Me                                                    1242  6-Ph   0 Me H      OMe                                                   1243  6-Ph   0 Me Cl     Cl                                                    1244  6-Ph   0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           1245  6-Ph   0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           1246  6-Ph   0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           1247  6-Ph   0 NO.sub.2                                                                          H      Cl                                                    1248  6-Ph   0 NO.sub.2                                                                          H      Br                                                    1249  6-Ph   0 NO.sub.2                                                                          H      F                                                     1250  6-Ph   0 NO.sub.2                                                                          H      CN                                                    1251  6-Ph   0 NO.sub.2                                                                          H      SMe                                                   1252  6-Ph   0 NO.sub.2                                                                          H      CF.sub.3                                              1253  6-Ph   0 NO.sub.2                                                                          OMe    Cl                                                    1254  6-Ph   0 NO.sub.2                                                                          OMe    CF.sub.3                                              1255  6-Ph   0 CF.sub.3                                                                          H      Cl                                                    1256  6-Ph   0 CF.sub.3                                                                          H      Br                                                    1257  6-Ph   0 CF.sub.3                                                                          H      SMe                                                   1258  6-Ph   0 CF.sub.3                                                                          H      CF.sub.3                                              1259  6-Ph   0 OMe                                                                               H      Cl                                                    1260  6-Ph   0 OMe                                                                               H      OMe                                                   1261  6-Ph   1 Cl H      Cl                                                    1262  6-Ph   1 Cl H      SO.sub.2 Me                                           1263  6-Ph   1 Cl H      NO.sub.2                                              1264  6-Ph   1 Cl H      OMe                                                   1265  6-Ph   1 Cl H      Me                                                    1266  6-Ph   1 Cl H      Br                                                    1267  6-Ph   1 Cl H      F                                                     1268  6-Ph   1 Cl H      SMe                                                   1269  6-Ph   1 Cl H      S(O)Me                                                1270  6-Ph   1 Cl H      CF.sub.3                                              1271  6-Ph   1 Cl H      CN                                                    1272  6-Ph   1 Cl Cl     Cl                                                    1273  6-Ph   1 Cl Cl     OMe                                                   1274  6-Ph   1 Cl Cl     SMe                                                   1275  6-Ph   1 Cl Cl     SO.sub.2 Me                                           1276  6-Ph   1 Cl Me     Cl                                                    1277  6-Ph   1 Cl Me     SO.sub.2 Me                                           1278  6-Ph   1 Cl OMe    Cl                                                    1279  6-Ph   1 Cl OMe    Br                                                    1280  6-Ph   1 Cl OMe    SO.sub.2 Me                                           1281  6-Ph   1 Cl OEt    Br                                                    1282  6-Ph   1 Br H      OMe                                                   1283  6-Ph   1 F  H      F                                                     1284  6-Ph   1 I  I      I                                                     1285  6-Ph   1 Me H      CN                                                    1286  6-Ph   1 Me H      Me                                                    1287  6-Ph   1 Me H      OMe                                                   1288  6-Ph   1 Me Cl     Cl                                                    1289  6-Ph   1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           1290  6-Ph   1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           1291  6-Ph   1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           1292  6-Ph   1 NO.sub.2                                                                          H      Cl                                                    1293  6-Ph   1 NO.sub.2                                                                          H      Br                                                    1294  6-Ph   1 NO.sub.2                                                                          H      F                                                     1295  6-Ph   1 NO.sub.2                                                                          H      CN                                                    1296  6-Ph   1 NO.sub.2                                                                          H      SMe                                                   1297  6-Ph   1 NO.sub.2                                                                          H      CF.sub.3                                              1298  6-Ph   1 NO.sub.2                                                                          OMe    Cl                                                    1299  6-Ph   1 NO.sub.2                                                                          OMe    CF.sub.3                                              1300  6-Ph   1 CF.sub.3                                                                          H      Cl                                                    1301  6-Ph   1 CF.sub.3                                                                          H      Br                                                    1302  6-Ph   1 CF.sub.3                                                                          H      SMe                                                   1303  6-Ph   1 CF.sub.3                                                                          H      CF.sub.3                                              1304  6-Ph   1 OMe                                                                               H      Cl                                                    1305  6-Ph   1 OMe                                                                               H      OMe                                                   1306  6-Ph   2 Cl H      Cl                                                    1307  6-Ph   2 Cl H      SO.sub.2 Me                                           1308  6-Ph   2 Cl H      NO.sub.2                                              1309  6-Ph   2 Cl H      OMe                                                   1310  6-Ph   2 Cl H      Me                                                    1311  6-Ph   2 Cl H      Br                                                    1312  6-Ph   2 Cl H      F                                                     1313  6-Ph   2 Cl H      SMe                                                   1314  6-Ph   2 Cl H      S(O)Me                                                1315  6-Ph   2 Cl H      CF.sub.3                                              1316  6-Ph   2 Cl H      CN                                                    1317  6-Ph   2 Cl Cl     Cl                                                    1318  6-Ph   2 Cl Cl     OMe                                                   1319  6-Ph   2 Cl Cl     SMe                                                   1320  6-Ph   2 Cl Cl     SO.sub.2 Me                                           1321  6-Ph   2 Cl Me     Cl                                                    1322  6-Ph   2 Cl Me     SO.sub.2 Me                                           1323  6-Ph   2 Cl OMe    Cl                                                    1324  6-Ph   2 Cl OMe    Br                                                    1325  6-Ph   2 Cl OMe    SO.sub.2 Me                                           1326  6-Ph   2 Cl OEt    Br                                                    1327  6-Ph   2 Br H      OMe                                                   1328  6-Ph   2 F  H      F                                                     1329  6-Ph   2 I  I      I                                                     1330  6-Ph   2 Me H      CN                                                    1331  6-Ph   2 Me H      Me                                                    1332  6-Ph   2 Me H      OMe                                                   1333  6-Ph   2 Me Cl     Cl                                                    1334  6-Ph   2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           1335  6-Ph   2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           1336  6-Ph   2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           1337  6-Ph   2 NO.sub.2                                                                          H      Cl                                                    1338  6-Ph   2 NO.sub.2                                                                          H      Br                                                    1339  6-Ph   2 NO.sub.2                                                                          H      F                                                     1340  6-Ph   2 NO.sub.2                                                                          H      CN                                                    1341  6-Ph   2 NO.sub.2                                                                          H      SMe                                                   1342  6-Ph   2 NO.sub.2                                                                          H      CF.sub.3                                              1343  6-Ph   2 NO.sub.2                                                                          OMe    Cl                                                    1344  6-Ph   2 NO.sub.2                                                                          OMe    CF.sub.3                                              1345  6-Ph   2 CF.sub.3                                                                          H      Cl                                                    1346  6-Ph   2 CF.sub.3                                                                          H      Br                                                    1347  6-Ph   2 CF.sub.3                                                                          H      SMe                                                   1348  6-Ph   2 CF.sub.3                                                                          H      CF.sub.3                                              1349  6-Ph   2 OMe                                                                               H      Cl                                                    1350  6-Ph   2 OMe                                                                               H      OMe                                                   1351  5-(4-ClPh)                                                                            0 Cl H      Cl                                                    1352  5-(4-ClPh)                                                                            0 Cl H      SO.sub.2 Me                                           1353  5-(4-ClPh)                                                                            0 Cl H      NO.sub.2                                              1354  5-(4-ClPh)                                                                            0 Cl H      OMe                                                   1355  5-(4-ClPh)                                                                            0 Cl H      Me                                                    1356  5-(4-ClPh)                                                                            0 Cl H      Br                                                    1357  5-(4-ClPh)                                                                            0 Cl H      F                                                     1358  5-(4-ClPh)                                                                            0 Cl H      SMe                                                   1359  5-(4-ClPh)                                                                            0 Cl H      S(O)Me                                                1360  5-(4-ClPh)                                                                            0 Cl H      CF.sub.3                                              1361  5-(4-ClPh)                                                                            0 Cl H      CN                                                    1362  5-(4-ClPh)                                                                            0 Cl Cl     Cl                                                    1363  5-(4-ClPh)                                                                            0 Cl Cl     OMe                                                   1364  5-(4-ClPh)                                                                            0 Cl Cl     SMe                                                   1365  5-(4-ClPh)                                                                            0 Cl Cl     SO.sub.2 Me                                           1366  5-(4-ClPh)                                                                            0 Cl Me     Cl                                                    1367  5-(4-ClPh)                                                                            0 Cl Me     SO.sub.2 Me                                           1368  5-(4-ClPh)                                                                            0 Cl OMe    Cl                                                    1369  5-(4-ClPh)                                                                            0 Cl OMe    Br                                                    1370  5-(4-ClPh)                                                                            0 Cl OMe    SO.sub.2 Me                                           1371  5-(4-ClPh)                                                                            0 Cl OEt    Br                                                    1372  5-(4-ClPh)                                                                            0 Br H      OMe                                                   1373  5-(4-ClPh)                                                                            0 F  H      F                                                     1374  5-(4-ClPh)                                                                            0 I  I      I                                                     1375  5-(4-ClPh)                                                                            0 Me H      CN                                                    1376  5-(4-ClPh)                                                                            0 Me H      Me                                                    1377  5-(4-ClPh)                                                                            0 Me H      OMe                                                   1378  5-(4-ClPh)                                                                            0 Me Cl     Cl                                                    1379  5-(4-ClPh)                                                                            0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           1380  5-(4-ClPh)                                                                            0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           1381  5-(4-ClPh)                                                                            0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           1382  5-(4-ClPh)                                                                            0 NO.sub.2                                                                          H      Cl                                                    1383  5-(4-ClPh)                                                                            0 NO.sub.2                                                                          H      Br                                                    1384  5-(4-ClPh)                                                                            0 NO.sub.2                                                                          H      F                                                     1385  5-(4-ClPh)                                                                            0 NO.sub.2                                                                          H      CN                                                    1386  5-(4-ClPh)                                                                            0 NO.sub.2                                                                          H      SMe                                                   1387  5-(4-ClPh)                                                                            0 NO.sub.2                                                                          H      CF.sub.3                                              1388  5-(4-ClPh)                                                                            0 NO.sub.2                                                                          OMe    Cl                                                    1389  5-(4-ClPh)                                                                            0 NO.sub.2                                                                          OMe    CF.sub.3                                              1390  5-(4-ClPh)                                                                            0 CF.sub.3                                                                          H      Cl                                                    1391  5-(4-ClPh)                                                                            0 CF.sub.3                                                                          H      Br                                                    1392  5-(4-ClPh)                                                                            0 CF.sub.3                                                                          H      SMe                                                   1393  5-(4-ClPh)                                                                            0 CF.sub.3                                                                          H      CF.sub.3                                              1394  5-(4-ClPh)                                                                            0 OMe                                                                               H      Cl                                                    1395  5-(4-ClPh)                                                                            0 OMe                                                                               H      OMe                                                   1396  5-(4-ClPh)                                                                            1 Cl H      Cl                                                    1397  5-(4-ClPh)                                                                            1 Cl H      SO.sub.2 Me                                           1398  5-(4-ClPh)                                                                            1 Cl H      NO.sub.2                                              1399  5-(4-ClPh)                                                                            1 Cl H      OMe                                                   1400  5-(4-ClPh)                                                                            1 Cl H      Me                                                    1401  5-(4-ClPh)                                                                            1 Cl H      Br                                                    1402  5-(4-ClPh)                                                                            1 Cl H      F                                                     1403  5-(4-ClPh)                                                                            1 Cl H      SMe                                                   1404  5-(4-ClPh)                                                                            1 Cl H      S(O)Me                                                1405  5-(4-ClPh)                                                                            1 Cl H      CF.sub.3                                              1406  5-(4-ClPh)                                                                            1 Cl H      CN                                                    1407  5-(4-ClPh)                                                                            1 Cl Cl     Cl                                                    1408  5-(4-ClPh)                                                                            1 Cl Cl     OMe                                                   1409  5-(4-ClPh)                                                                            1 Cl Cl     SMe                                                   1410  5-(4-ClPh)                                                                            1 Cl Cl     SO.sub.2 Me                                           1411  5-(4-ClPh)                                                                            1 Cl Me     Cl                                                    1412  5-(4-ClPh)                                                                            1 Cl Me     SO.sub.2 Me                                           1413  5-(4-ClPh)                                                                            1 Cl OMe    Cl                                                    1414  5-(4-ClPh)                                                                            1 Cl OMe    Br                                                    1415  5-(4-ClPh)                                                                            1 Cl OMe    SO.sub.2 Me                                           1416  5-(4-ClPh)                                                                            1 Cl OEt    Br                                                    1417  5-(4-ClPh)                                                                            1 Br H      OMe                                                   1418  5-(4-ClPh)                                                                            1 F  H      F                                                     1419  5-(4-ClPh)                                                                            1 I  I      I                                                     1420  5-(4-ClPh)                                                                            1 Me H      CN                                                    1421  5-(4-ClPh)                                                                            1 Me H      Me                                                    1422  5-(4-ClPh)                                                                            1 Me H      OMe                                                   1423  5-(4-ClPh)                                                                            1 Me Cl     Cl                                                    1424  5-(4-ClPh)                                                                            1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           1425  5-(4-ClPh)                                                                            1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           1426  5-(4-ClPh)                                                                            1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           1427  5-(4-ClPh)                                                                            1 NO.sub.2                                                                          H      Cl                                                    1428  5-(4-ClPh)                                                                            1 NO.sub.2                                                                          H      Br                                                    1429  5-(4-ClPh)                                                                            1 NO.sub.2                                                                          H      F                                                     1430  5-(4-ClPh)                                                                            1 NO.sub.2                                                                          H      CN                                                    1431  5-(4-ClPh)                                                                            1 NO.sub.2                                                                          H      SMe                                                   1432  5-(4-ClPh)                                                                            1 NO.sub.2                                                                          H      CF.sub.3                                              1433  5-(4-ClPh)                                                                            1 NO.sub.2                                                                          OMe    Cl                                                    1434  5-(4-ClPh)                                                                            1 NO.sub.2                                                                          OMe    CF.sub.3                                              1435  5-(4-ClPh)                                                                            1 CF.sub.3                                                                          H      Cl                                                    1436  5-(4-ClPh)                                                                            1 CF.sub.3                                                                          H      Br                                                    1437  5-(4-ClPh)                                                                            1 CF.sub.3                                                                          H      SMe                                                   1438  5-(4-ClPh)                                                                            1 CF.sub.3                                                                          H      CF.sub.3                                              1439  5-(4-ClPh)                                                                            1 OMe                                                                               H      Cl                                                    1440  5-(4-ClPh)                                                                            1 OMe                                                                               H      OMe                                                   1441  5-(4-ClPh)                                                                            2 Cl H      Cl                                                    1442  5-(4-ClPh)                                                                            2 Cl H      SO.sub.2 Me                                           1443  5-(4-ClPh)                                                                            2 Cl H      NO.sub.2                                              1444  5-(4-ClPh)                                                                            2 Cl H      OMe                                                   1445  5-(4-ClPh)                                                                            2 Cl H      Me                                                    1446  5-(4-ClPh)                                                                            2 Cl H      Br                                                    1447  5-(4-ClPh)                                                                            2 Cl H      F                                                     1448  5-(4-ClPh)                                                                            2 Cl H      SMe                                                   1449  5-(4-ClPh)                                                                            2 Cl H      S(O)Me                                                1450  5-(4-ClPh)                                                                            2 Cl H      CF.sub.3                                              1451  5-(4-ClPh)                                                                            2 Cl H      CN                                                    1452  5-(4-ClPh)                                                                            2 Cl Cl     Cl                                                    1453  5-(4-ClPh)                                                                            2 Cl Cl     OMe                                                   1454  5-(4-ClPh)                                                                            2 Cl Cl     SMe                                                   1455  5-(4-ClPh)                                                                            2 Cl Cl     SO.sub.2 Me                                           1456  5-(4-ClPh)                                                                            2 Cl Me     Cl                                                    1457  5-(4-ClPh)                                                                            2 Cl Me     SO.sub.2 Me                                           1458  5-(4-ClPh)                                                                            2 Cl OMe    Cl                                                    1459  5-(4-ClPh)                                                                            2 Cl OMe    Br                                                    1460  5-(4-ClPh)                                                                            2 Cl OMe    SO.sub.2 Me                                           1461  5-(4-ClPh)                                                                            2 Cl OEt    Br                                                    1462  5-(4-ClPh)                                                                            2 Br H      OMe                                                   1463  5-(4-ClPh)                                                                            2 F  H      F                                                     1464  5-(4-ClPh)                                                                            2 I  I      I                                                     1465  5-(4-ClPh)                                                                            2 Me H      CN                                                    1466  5-(4-ClPh)                                                                            2 Me H      Me                                                    1467  5-(4-ClPh)                                                                            2 Me H      OMe                                                   1468  5-(4-ClPh)                                                                            2 Me Cl     Cl                                                    1469  5-(4-ClPh)                                                                            2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           1470  5-(4-ClPh)                                                                            2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           1471  5-(4-ClPh)                                                                            2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           1472  5-(4-ClPh)                                                                            2 NO.sub.2                                                                          H      Cl                                                    1473  5-(4-ClPh)                                                                            2 NO.sub.2                                                                          H      Br                                                    1474  5-(4-ClPh)                                                                            2 NO.sub.2                                                                          H      F                                                     1475  5-(4-ClPh)                                                                            2 NO.sub.2                                                                          H      CN                                                    1476  5-(4-ClPh)                                                                            2 NO.sub.2                                                                          H      SMe                                                   1477  5-(4-ClPh)                                                                            2 NO.sub.2                                                                          H      CF.sub.3                                              1478  5-(4-ClPh)                                                                            2 NO.sub.2                                                                          OMe    Cl                                                    1479  5-(4-ClPh)                                                                            2 NO.sub.2                                                                          OMe    CF.sub.3                                              1480  5-(4-ClPh)                                                                            2 CF.sub.3                                                                          H      Cl                                                    1481  5-(4-ClPh)                                                                            2 CF.sub.3                                                                          H      Br                                                    1482  5-(4-ClPh)                                                                            2 CF.sub.3                                                                          H      SMe                                                   1483  5-(4-ClPh)                                                                            2 CF.sub.3                                                                          H      CF.sub.3                                              1484  5-(4-ClPh)                                                                            2 OMe                                                                               H      Cl                                                    1485  5-(4-ClPh)                                                                            2 OMe                                                                               H      OMe                                                   1486  5-(4-MePh)                                                                            0 Cl H      Cl                                                    1487  5-(4-MePh)                                                                            0 Cl H      SO.sub.2 Me                                           1488  5-(4-MePh)                                                                            0 Cl H      NO.sub.2                                              1489  5-(4-MePh)                                                                            0 Cl H      OMe                                                   1490  5-(4-MePh)                                                                            0 Cl H      Me                                                    1491  5-(4-MePh)                                                                            0 Cl H      Br                                                    1492  5-(4-MePh)                                                                            0 Cl H      F                                                     1493  5-(4-MePh)                                                                            0 Cl H      SMe                                                   1494  5-(4-MePh)                                                                            0 Cl H      S(O)Me                                                1495  5-(4-MePh)                                                                            0 Cl H      CF.sub.3                                              1496  5-(4-MePh)                                                                            0 Cl H      CN                                                    1497  5-(4-MePh)                                                                            0 Cl Cl     Cl                                                    1498  5-(4-MePh)                                                                            0 Cl Cl     OMe                                                   1499  5-(4-MePh)                                                                            0 Cl Cl     SMe                                                   1500  5-(4-MePh)                                                                            0 Cl Cl     SO.sub.2 Me                                           1501  5-(4-MePh)                                                                            0 Cl Me     Cl                                                    1502  5-(4-MePh)                                                                            0 Cl Me     SO.sub.2 Me                                           1503  5-(4-MePh)                                                                            0 Cl OMe    Cl                                                    1504  5-(4-MePh)                                                                            0 Cl OMe    Br                                                    1505  5-(4-MePh)                                                                            0 Cl OMe    SO.sub.2 Me                                           1506  5-(4-MePh)                                                                            0 Cl OEt    Br                                                    1507  5-(4-MePh)                                                                            0 Br H      OMe                                                   1508  5-(4-MePh)                                                                            0 F  H      F                                                     1509  5-(4-MePh)                                                                            0 I  I      I                                                     1510  5-(4-MePh)                                                                            0 Me H      CN                                                    1511  5-(4-Me Ph)                                                                           0 Me H      Me                                                    1512  5-(4-MePh)                                                                            0 Me H      OMe                                                   1513  5-(4-MePh)                                                                            0 Me Cl     Cl                                                    1514  5-(4-MePh)                                                                            0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           1515  5-(4-MePh)                                                                            0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           1516  5-(4-MePh)                                                                            0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           1517  5-(4-MePh)                                                                            0 NO.sub.2                                                                          H      Cl                                                    1518  5-(4-MePh)                                                                            0 NO.sub.2                                                                          H      Br                                                    1519  5-(4-MePh)                                                                            0 NO.sub.2                                                                          H      F                                                     1520  5-(4-MePh)                                                                            0 NO.sub.2                                                                          H      CN                                                    1521  5-(4-MePh)                                                                            0 NO.sub.2                                                                          H      SMe                                                   1522  5-(4-MePh)                                                                            0 NO.sub.2                                                                          H      CF.sub.3                                              1523  5-(4-MePh)                                                                            0 NO.sub.2                                                                          OMe    Cl                                                    1524  5-(4-MePh)                                                                            0 NO.sub.2                                                                          OMe    CF.sub.3                                              1525  5-(4-MePh)                                                                            0 CF.sub.3                                                                          H      Cl                                                    1526  5-(4-MePh)                                                                            0 CF.sub.3                                                                          H      Br                                                    1527  5-(4-MePh)                                                                            0 CF.sub.3                                                                          H      SMe                                                   1528  5-(4-MePh)                                                                            0 CF.sub.3                                                                          H      CF.sub.3                                              1529  5-(4-MePh)                                                                            0 OMe                                                                               H      Cl                                                    1530  5-(4-MePh)                                                                            0 OMe                                                                               H      OMe                                                   1531  5-(4-MePh)                                                                            1 Cl H      Cl                                                    1532  5-(4-MePh)                                                                            1 Cl H      SO.sub.2 Me                                           1533  5-(4-MePh)                                                                            1 Cl H      NO.sub.2                                              1534  5-(4-MePh)                                                                            1 Cl H      OMe                                                   1535  5-(4-MePh)                                                                            1 Cl H      Me                                                    1536  5-(4-MePh)                                                                            1 Cl H      Br                                                    1537  5-(4-MePh)                                                                            1 Cl H      F                                                     1538  5-(4-MePh)                                                                            1 Cl H      SMe                                                   1539  5-(4-MePh)                                                                            1 Cl H      S(O)Me                                                1540  5-(4-MePh)                                                                            1 Cl H      CF.sub.3                                              1541  5-(4-MePh)                                                                            1 Cl H      CN                                                    1542  5-(4-MePh)                                                                            1 Cl Cl     Cl                                                    1543  5-(4-MePh)                                                                            1 Cl Cl     OMe                                                   1544  5-(4-MePh)                                                                            1 Cl Cl     SMe                                                   1545  5-(4-MePh)                                                                            1 Cl Cl     SO.sub.2 Me                                           1546  5-(4-MePh)                                                                            1 Cl Me     Cl                                                    1547  5-(4-MePh)                                                                            1 Cl Me     SO.sub.2 Me                                           1548  5-(4-MePh)                                                                            1 Cl OMe    Cl                                                    1549  5-(4-MePh)                                                                            1 Cl OMe    Br                                                    1550  5-(4-MePh)                                                                            1 Cl OMe    SO.sub.2 Me                                           1551  5-(4-MePh)                                                                            1 Cl OEt    Br                                                    1552  5-(4-MePh)                                                                            1 Br H      OMe                                                   1553  5-(4-MePh)                                                                            1 F  H      F                                                     1554  5-(4-MePh)                                                                            1 I  I      I                                                     1555  5-(4-MePh)                                                                            1 Me H      CN                                                    1556  5-(4-MePh)                                                                            1 Me H      Me                                                    1557  5-(4-MePh)                                                                            1 Me H      OMe                                                   1558  5-(4-MePh)                                                                            1 Me Cl     Cl                                                    1559  5-(4-MePh)                                                                            1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           1560  5-(4-MePh)                                                                            1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           1561  5-(4-MePh)                                                                            1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           1562  5-(4-MePh)                                                                            1 NO.sub.2                                                                          H      Cl                                                    1563  5-(4-MePh)                                                                            1 NO.sub.2                                                                          H      Br                                                    1564  5-(4-MePh)                                                                            1 NO.sub.2                                                                          H      F                                                     1565  5-(4-MePh)                                                                            1 NO.sub.22                                                                         H      CN                                                    1566  5-(4-MePh)                                                                            1 NO.sub.2                                                                          H      SMe                                                   1567  5-(4-MePh)                                                                            1 NO.sub.2                                                                          H      CF.sub.3                                              1568  5-(4-MePh)                                                                            1 NO.sub.2                                                                          OMe    Cl                                                    1569  5-(4-MePh)                                                                            1 NO.sub.2                                                                          OMe    CF.sub.3                                              1570  5-(4-MePh)                                                                            1 CF.sub.3                                                                          H      Cl                                                    1571  5-(4-MePh)                                                                            1 CF.sub.3                                                                          H      Br                                                    1572  5-(4-MePh)                                                                            1 CF.sub.3                                                                          H      SMe                                                   1573  5-(4-MePh)                                                                            1 CF.sub.3                                                                          H      CF.sub.3                                              1574  5-(4-MePh)                                                                            1 OMe                                                                               H      Cl                                                    1575  5-(4-MePh)                                                                            1 OMe                                                                               H      OMe                                                   1576  5-(4-MePh)                                                                            2 Cl H      Cl                                                    1577  5-(4-MePh)                                                                            2 Cl H      SO.sub.2 Me                                           1578  5-(4-MePh)                                                                            2 Cl H      NO.sub.2                                              1579  5-(4-MePh)                                                                            2 Cl H      OMe                                                   1580  5-(4-MePh)                                                                            2 Cl H      Me                                                    1581  5-(4-MePh)                                                                            2 Cl H      Br                                                    1582  5-(4-MePh)                                                                            2 Cl H      F                                                     1583  5-(4-MePh)                                                                            2 Cl H      SMe                                                   1584  5-(4-MePh)                                                                            2 Cl H      S(O)Me                                                1585  5-(4-MePh)                                                                            2 Cl H      CF.sub.3                                              1586  5-(4-MePh)                                                                            2 Cl H      CN                                                    1587  5-(4-MePh)                                                                            2 Cl Cl     Cl                                                    1588  5-(4-MePh)                                                                            2 Cl Cl     OMe                                                   1589  5-(4-MePh)                                                                            2 Cl Cl     SMe                                                   1590  5-(4-MePh)                                                                            2 Cl Cl     SO.sub.2 Me                                           1591  5-(4-MePh)                                                                            2 Cl Me     Cl                                                    1592  5-(4-MePh)                                                                            2 Cl Me     SO.sub.2 Me                                           1593  5-(4-MePh)                                                                            2 Cl OMe    Cl                                                    1594  5-(4-MePh)                                                                            2 Cl OMe    Br                                                    1595  5-(4-MePh)                                                                            2 Cl OMe    SO.sub.2 Me                                           1596  5-(4-MePh)                                                                            2 Cl OEt    Br                                                    1597  5-(4-MePh)                                                                            2 Br H      OMe                                                   1598  5-(4-MePh)                                                                            2 F  H      F                                                     1599  5-(4-MePh)                                                                            2 I  I      I                                                     1600  5-(4-MePh)                                                                            2 Me H      CN                                                    1601  5-(4-MePh)                                                                            2 Me H      Me                                                    1602  5-(4-MePh)                                                                            2 Me H      OMe                                                   1603  5-(4-MePh)                                                                            2 Me Cl     Cl                                                    1604  5-(4-MePh)                                                                            2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                           1605  5-(4-MePh)                                                                            2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                           1606  5-(4-MePh)                                                                            2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                           1607  5-(4-MePh)                                                                            2 NO.sub.2                                                                          H      Cl                                                    1608  5-(4-MePh)                                                                            2 NO.sub.2                                                                          H      Br                                                    1609  5-(4-MePh)                                                                            2 NO.sub.2                                                                          H      F                                                     1610  5-(4-MePh)                                                                            2 NO.sub.22                                                                         H      CN                                                    1611  5-(4-MePh)                                                                            2 NO.sub.2                                                                          H      SMe                                                   1612  5-(4-MePh)                                                                            2 NO.sub.2                                                                          H      CF.sub.3                                              1613  5-(4-MePh)                                                                            2 NO.sub.2                                                                          OMe    Cl                                                    1614  5-(4-MePh)                                                                            2 NO.sub.2                                                                          OMe    CF.sub.3                                              1615  5-(4-MePh)                                                                            2 CF.sub.3                                                                          H      Cl                                                    1616  5-(4-MePh)                                                                            2 CF.sub.3                                                                          H      Br                                                    1617  5-(4-MePh)                                                                            2 CF.sub.3                                                                          H      SMe                                                   1618  5-(4-MePh)                                                                            2 CF.sub.3                                                                          H      CF.sub.3                                              1619  5-(4-MePh)                                                                            2 OMe                                                                               H      Cl                                                    1620  5-(4-MePh)                                                                            2 OMe                                                                               H      OMe                                                   __________________________________________________________________________

                                      TABLE 2                                      __________________________________________________________________________      ##STR17##                                                                     Compound                                                                       No. of the                                                                     present                     Characteristic                                     invention                                                                            (R).sub.m                                                                           L X  Y      Z    (Physical property)                                __________________________________________________________________________     1621  --   0 Cl H      Cl                                                      1622  --   0 Cl H      SO.sub.2 Me                                             1623  --   0 Cl H      NO.sub.2                                                1624  --   0 Cl H      OMe                                                     1625  --   0 Cl H      Me                                                      1626  --   0 Cl H      Br                                                      1627  --   0 Cl H      F                                                       1628  --   0 Cl H      SMe                                                     1629  --   0 Cl H      S(O)Me                                                  1630  --   0 Cl H      CF.sub.3                                                1631  --   0 Cl H      CN                                                      1632  --   0 Cl Cl     Cl                                                      1633  --   0 Cl Cl     OMe                                                     1634  --   0 Cl Cl     SMe                                                     1635  --   0 Cl Cl     SO.sub.2 Me                                             1636  --   0 Cl Me     Cl                                                      1637  --   0 Cl Me     SO.sub.2 Me                                             1638  --   0 Cl OMe    Cl                                                      1639  --   0 Cl OMe    Br                                                      1640  --   0 Cl OMe    SO.sub.2 Me                                             1641  --   0 Cl OEt    Br                                                      1642  --   0 Br H      OMe                                                     1643  --   0 F  H      F                                                       1644  --   0 I  I      I                                                       1645  --   0 Me H      CN                                                      1626  --   0 Me H      Me                                                      1627  --   0 Me H      OMe                                                     1628  --   0 Me Cl     Cl                                                      1629  --   0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             1630  --   0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             1631  --   0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             1632  --   0 NO.sub.2                                                                          H      Cl                                                      1633  --   0 NO.sub.2                                                                          H      Br                                                      1634  --   0 NO.sub.2                                                                          H      F                                                       1635  --   0 NO.sub.2                                                                          H      CN                                                      1636  --   0 NO.sub.2                                                                          H      SMe                                                     1637  --   0 NO.sub.2                                                                          H      CF.sub.3                                                1638  --   0 NO.sub.2                                                                          OMe    Cl                                                      1639  --   0 NO.sub.2                                                                          OMe    CF.sub.3                                                1640  --   0 CF.sub.3                                                                          H      Cl                                                      1641  --   0 CF.sub.3                                                                          H      Br                                                      1642  --   0 CF.sub.3                                                                          H      SMe                                                     1643  --   0 CF.sub.3                                                                          H      CF.sub.3                                                1644  --   0 OMe                                                                               H      Cl                                                      1645  --   0 OMe                                                                               H      OMe                                                     1646  --   1 Cl H      Cl                                                      1647  --   1 Cl H      SO.sub.2 Me                                             1648  --   1 Cl H      NO.sub.2                                                1649  --   1 Cl H      OMe                                                     1650  --   1 Cl H      Me                                                      1651  --   1 Cl H      Br                                                      1652  --   1 Cl H      F                                                       1653  --   1 Cl H      SMe                                                     1654  --   1 Cl H      S(O)Me                                                  1655  --   1 Cl H      CF.sub.3                                                1656  --   1 Cl H      CN                                                      1657  --   1 Cl Cl     Cl                                                      1658  --   1 Cl Cl     OMe                                                     1659  --   1 Cl Cl     SMe                                                     1660  --   1 Cl Cl     SO.sub.2 Me                                             1661  --   1 Cl Me     Cl                                                      1662  --   1 Cl Me     SO.sub.2 Me                                             1663  --   1 Cl OMe    Cl                                                      1664  --   1 Cl OMe    Br                                                      1665  --   1 Cl OMe    SO.sub.2 Me                                             1666  --   1 Cl OEt    Br                                                      1667  --   1 Br H      OMe                                                     1668  --   1 F  H      F                                                       1669  --   1 I  I      I                                                       1670  --   1 Me H      CN                                                      1671  --   1 Me H      Me                                                      1672  --   1 Me H      OMe                                                     1673  --   1 Me Cl     Cl                                                      1674  --   1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             1675  --   1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             1676  --   1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             1677  --   1 NO.sub.2                                                                          H      Cl                                                      1678  --   1 NO.sub.2                                                                          H      Br                                                      1679  --   1 NO.sub.2                                                                          H      F                                                       1680  --   1 NO.sub.2                                                                          H      CN                                                      1681  --   1 NO.sub.2                                                                          H      SMe                                                     1682  --   1 NO.sub.2                                                                          H      CF.sub.3                                                1683  --   1 NO.sub.2                                                                          OMe    Cl                                                      1684  --   1 NO.sub.2                                                                          OMe    CF.sub.3                                                1685  --   1 CF.sub.3                                                                          H      Cl                                                      1686  --   1 CF.sub.3                                                                          H      Br                                                      1687  --   1 CF.sub.3                                                                          H      SMe                                                     1688  --   1 CF.sub.3                                                                          H      CF.sub.3                                                1689  --   1 OMe                                                                               H      Cl                                                      1690  --   1 OMe                                                                               H      OMe                                                     1691  --   2 Cl H      Cl                                                      1692  --   2 Cl H      SO.sub.2 Me                                             1693  --   2 Cl H      NO.sub.2                                                1694  --   2 Cl H      OMe                                                     1695  --   2 Cl H      Me                                                      1696  --   2 Cl H      Br                                                      1697  --   2 Cl H      F                                                       1698  --   2 Cl H      SMe                                                     1699  --   2 Cl H      S(O)Me                                                  1700  --   2 Cl H      CF.sub.3                                                1701  --   2 Cl H      CN                                                      1702  --   2 Cl Cl     Cl                                                      1703  --   2 Cl Cl     OMe                                                     1704  --   2 Cl Cl     SMe                                                     1705  --   2 Cl Cl     SO.sub.2 Me                                             1706  --   2 Cl Me     Cl                                                      1707  --   2 Cl Me     SO.sub.2 Me                                             1708  --   2 Cl OMe    Cl                                                      1709  --   2 Cl OMe    Br                                                      1710  --   2 Cl OMe    SO.sub.2 Me                                             1711  --   2 Cl OEt    Br                                                      1712  --   2 Br H      OMe                                                     1713  --   2 F  H      F                                                       1714  --   2 I  I      I                                                       1715  --   2 Me H      CN                                                      1716  --   2 Me H      Me                                                      1717  --   2 Me H      OMe                                                     1718  --   2 Me Cl     Cl                                                      1719  --   2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             1720  --   2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             1721  --   2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             1722  --   2 NO.sub.2                                                                          H      Cl                                                      1723  --   2 NO.sub.2                                                                          H      Br                                                      1724  --   2 NO.sub.2                                                                          H      F                                                       1725  --   2 NO.sub.2                                                                          H      CN                                                      1726  --   2 NO.sub.2                                                                          H      SMe                                                     1727  --   2 NO.sub.2                                                                          H      CF.sub.3                                                1728  --   2 NO.sub.2                                                                          OMe    Cl                                                      1729  --   2 NO.sub.2                                                                          OMe    CF.sub.3                                                1730  --   2 CF.sub.3                                                                          H      Cl                                                      1731  --   2 CF.sub.3                                                                          H      Br                                                      1732  --   2 CF.sub.3                                                                          H      SMe                                                     1733  --   2 CF.sub.3                                                                          H      CF.sub.3                                                1734  --   2 OMe                                                                               H      Cl                                                      1735  --   2 OMe                                                                               H      OMe                                                     1736  4-Me 0 Cl H      Cl   Dark green crystal                                                             m.p. 55˜58° C.                        1737  4-Me 0 Cl H      SO.sub.2 Me                                             1738  4-Me 0 Cl H      NO.sub.2                                                1739  4-Me 0 Cl H      OMe                                                     1740  4-Me 0 Cl H      Me                                                      1741  4-Me 0 Cl H      Br                                                      1742  4-Me 0 Cl H      F                                                       1743  4-Me 0 Cl H      SMe                                                     1744  4-Me 0 Cl H      S(O)Me                                                  1745  4-Me 0 Cl H      CF.sub.3                                                1746  4-Me 0 Cl H      CN                                                      1747  4-Me 0 Cl Cl     Cl                                                      1748  4-Me 0 Cl Cl     OMe                                                     1749  4-Me 0 Cl Cl     SMe                                                     1750  4-Me 0 Cl Cl     SO.sub.2 Me                                             1751  4-Me 0 Cl Me     Cl                                                      1752  4-Me 0 Cl Me     SO.sub.2 Me                                             1753  4-Me 0 Cl OMe    Cl                                                      1754  4-Me 0 Cl OMe    Br                                                      1755  4-Me 0 Cl OMe    SO.sub.2 Me                                             1756  4-Me 0 Cl OEt    Br                                                      1757  4-Me 0 Br H      OMe                                                     1758  4-Me 0 F  H      F                                                       1759  4-Me 0 I  I      I                                                       1760  4-Me 0 Me H      CN                                                      1761  4-Me 0 Me H      Me                                                      1762  4-Me 0 Me H      OMe                                                     1763  4-Me 0 Me Cl     Cl                                                      1764  4-Me 0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             1765  4-Me 0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             1766  4-Me 0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             1767  4-Me 0 NO.sub.2                                                                          H      Cl                                                      1768  4-Me 0 NO.sub.2                                                                          H      Br                                                      1769  4-Me 0 NO.sub.2                                                                          H      F                                                       1770  4-Me 0 NO.sub.2                                                                          H      CN                                                      1771  4-Me 0 NO.sub.2                                                                          H      SMe                                                     1772  4-Me 0 NO.sub.2                                                                          H      CF.sub.3                                                1773  4-Me 0 NO.sub.2                                                                          OMe    Cl                                                      1774  4-Me 0 NO.sub.2                                                                          OMe    CF.sub.3                                                1775  4-Me 0 CF.sub.3                                                                          H      Cl                                                      1776  4-Me 0 CF.sub.3                                                                          H      Br                                                      1777  4-Me 0 CF.sub.3                                                                          H      SMe                                                     1778  4-Me 0 CF.sub.3                                                                          H      CF.sub.3                                                1779  4-Me 0 OMe                                                                               H      Cl                                                      1780  4-Me 0 OMe                                                                               H      OMe                                                     1781  4-Me 1 Cl H      Cl                                                      1782  4-Me 1 Cl H      SO.sub.2 Me                                             1783  4-Me 1 Cl H      NO.sub.2                                                1784  4-Me 1 Cl H      OMe                                                     1785  4-Me 1 Cl H      Me                                                      1786  4-Me 1 Cl H      Br                                                      1787  4-Me 1 Cl H      F                                                       1788  4-Me 1 Cl H      SMe                                                     1789  4-Me 1 Cl H      S(O)Me                                                  1790  4-Me 1 Cl H      CF.sub.3                                                1791  4-Me 1 Cl H      CN                                                      1792  4-Me 1 Cl Cl     Cl                                                      1793  4-Me 1 Cl Cl     OMe                                                     1794  4-Me 1 Cl Cl     SMe                                                     1795  4-Me 1 Cl Cl     SO.sub.2 Me                                             1796  4-Me 1 Cl Me     Cl                                                      1797  4-Me 1 Cl Me     SO.sub.2 Me                                             1798  4-Me 1 Cl OMe    Cl                                                      1799  4-Me 1 Cl OMe    Br                                                      1800  4-Me 1 Cl OMe    SO.sub. 2 Me                                            1801  4-Me 1 Cl OEt    Br                                                      1802  4-Me 1 Br H      OMe                                                     1803  4-Me 1 F  H      F                                                       1804  4-Me 1 I  I      I                                                       1805  4-Me 1 Me H      CN                                                      1806  4-Me 1 Me H      Me                                                      1807  4-Me 1 Me H      OMe                                                     1808  4-Me 1 Me Cl     Cl                                                      1809  4-Me 1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             1810  4-Me 1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             1811  4-Me 1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             1812  4-Me 1 NO.sub.2                                                                          H      Cl                                                      1813  4-Me 1 NO.sub.2                                                                          H      Br                                                      1814  4-Me 1 NO.sub.2                                                                          H      F                                                       1815  4-Me 1 NO.sub.2                                                                          H      CN                                                      1816  4-Me 1 NO.sub.2                                                                          H      SMe                                                     1817  4-Me 1 NO.sub.2                                                                          H      CF.sub.3                                                1818  4-Me 1 NO.sub.2                                                                          OMe    Cl                                                      1819  4-Me 1 NO.sub.2                                                                          OMe    CF.sub.3                                                1820  4-Me 1 CF.sub.3                                                                          H      Cl                                                      1821  4-Me 1 CF.sub.3                                                                          H      Br                                                      1822  4-Me 1 CF.sub.3                                                                          H      SMe                                                     1823  4-Me 1 CF.sub.3                                                                          H      CF.sub.3                                                1824  4-Me 1 OMe                                                                               H      Cl                                                      1825  4-Me 1 OMe                                                                               H      OMe                                                     1826  4-Me 2 Cl H      Cl                                                      1827  4-Me 2 Cl H      SO.sub.2 Me                                             1828  4-Me 2 Cl H      NO.sub.2                                                1829  4-Me 2 Cl H      OMe                                                     1830  4-Me 2 Cl H      Me                                                      1831  4-Me 2 Cl H      Br                                                      1832  4-Me 2 Cl H      F                                                       1833  4-Me 2 Cl H      SMe                                                     1834  4-Me 2 Cl H      S(O)Me                                                  1835  4-Me 2 Cl H      CF.sub.3                                                1836  4-Me 2 Cl H      CN                                                      1837  4-Me 2 Cl Cl     Cl                                                      1838  4-Me 2 Cl Cl     OMe                                                     1839  4-Me 2 Cl Cl     SMe                                                     1840  4-Me 2 Cl Cl     SO.sub.2 Me                                             1841  4-Me 2 Cl Me     Cl                                                      1842  4-Me 2 Cl Me     SO.sub.2 Me                                             1843  4-Me 2 Cl OMe    Cl                                                      1844  4-Me 2 Cl OMe    Br                                                      1845  4-Me 2 Cl OMe    SO.sub.2 Me                                             1846  4-Me 2 Cl OEt    Br                                                      1847  4-Me 2 Br H      OMe                                                     1848  4-Me 2 F  H      F                                                       1849  4-Me 2 I  I      I                                                       1850  4-Me 2 Me H      CN                                                      1851  4-Me 2 Me H      Me                                                      1852  4-Me 2 Me H      OMe                                                     1853  4-Me 2 Me Cl     Cl                                                      1854  4-Me 2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             1855  4-Me 2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             1856  4-Me 2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             1857  4-Me 2 NO.sub.2                                                                          H      Cl                                                      1858  4-Me 2 NO.sub.2                                                                          H      Br                                                      1859  4-Me 2 NO.sub.2                                                                          H      F                                                       1860  4-Me 2 NO.sub.2                                                                          H      CN                                                      1861  4-Me 2 NO.sub.2                                                                          H      SMe                                                     1862  4-Me 2 NO.sub.2                                                                          H      CF.sub.3                                                1863  4-Me 2 NO.sub.2                                                                          OMe    Cl                                                      1864  4-Me 2 NO.sub.2                                                                          OMe    CF.sub.3                                                1865  4-Me 2 CF.sub.3                                                                          H      Cl                                                      1866  4-Me 2 CF.sub.3                                                                          H      Br                                                      1867  4-Me 2 CF.sub.3                                                                          H      SMe                                                     1868  4-Me 2 CF.sub.3                                                                          H      CF.sub.3                                                1869  4-Me 2 OMe                                                                               H      Cl                                                      1870  4-Me 2 OMe                                                                               H      OMe                                                     1871  5-Me 0 Cl H      Cl                                                      1872  5-Me 0 Cl H      SO.sub.2 Me                                             1873  5-Me 0 Cl H      NO.sub.2                                                1874  5-Me 0 Cl H      OMe                                                     1875  5-Me 0 Cl H      Me                                                      1876  5-Me 0 Cl H      Br                                                      1877  5-Me 0 Cl H      F                                                       1878  5-Me 0 Cl H      SMe                                                     1879  5-Me 0 Cl H      S(O)Me                                                  1880  5-Me 0 Cl H      CF.sub.3                                                1881  5-Me 0 Cl H      CN                                                      1882  5-Me 0 Cl Cl     Cl                                                      1883  5-Me 0 Cl Cl     OMe                                                     1884  5-Me 0 Cl Cl     SMe                                                     1885  5-Me 0 Cl Cl     SO.sub.2 Me                                             1886  5-Me 0 Cl Me     Cl                                                      1887  5-Me 0 Cl Me     SO.sub.2 Me                                             1888  5-Me 0 Cl OMe    Cl                                                      1889  5-Me 0 Cl OMe    Br                                                      1890  5-Me 0 Cl OMe    SO.sub.2 Me                                             1891  5-Me 0 Cl OEt    Br                                                      1892  5-Me 0 Br H      OMe                                                     1893  5-Me 0 F  H      F                                                       1894  5-Me 0 I  I      I                                                       1895  5-Me 0 Me H      CN                                                      1896  5-Me 0 Me H      Me                                                      1897  5-Me 0 Me H      OMe                                                     1898  5-Me 0 Me Cl     Cl                                                      1899  5-Me 0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             1900  5-Me 0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             1901  5-Me 0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             1902  5-Me 0 NO.sub.2                                                                          H      Cl                                                      1903  5-Me 0 NO.sub.2                                                                          H      Br                                                      1904  5-Me 0 NO.sub.2                                                                          H      F                                                       1905  5-Me 0 NO.sub.2                                                                          H      CN                                                      1906  5-Me 0 NO.sub.2                                                                          H      SMe                                                     1907  5-Me 0 NO.sub.2                                                                          H      CF.sub.3                                                1908  5-Me 0 NO.sub.2                                                                          OMe    Cl                                                      1909  5-Me 0 NO.sub.2                                                                          OMe    CF.sub.3                                                1910  5-Me 0 CF.sub.3                                                                          H      Cl                                                      1911  5-Me 0 CF.sub.3                                                                          H      Br                                                      1912  5-Me 0 CF.sub.3                                                                          H      SMe                                                     1913  5-Me 0 CF.sub.3                                                                          H      CF.sub.3                                                1914  5-Me 0 OMe                                                                               H      Cl                                                      1915  5-Me 0 OMe                                                                               H      OMe                                                     1916  5-Me 1 Cl H      Cl                                                      1917  5-Me 1 Cl H      SO.sub.2 Me                                             1918  5-Me 1 Cl H      NO.sub.2                                                1919  5-Me 1 Cl H      OMe                                                     1920  5-Me 1 Cl H      Me                                                      1921  5-Me 1 Cl H      Br                                                      1922  5-Me 1 Cl H      F                                                       1923  5-Me 1 Cl H      SMe                                                     1924  5-Me 1 Cl H      S(O)Me                                                  1925  5-Me 1 Cl H      CF.sub.3                                                1926  5-Me 1 Cl H      CN                                                      1927  5-Me 1 Cl Cl     Cl                                                      1928  5-Me 1 Cl Cl     OMe                                                     1929  5-Me 1 Cl Cl     SMe                                                     1930  5-Me 1 Cl Cl     SO.sub.2 Me                                             1931  5-Me 1 Cl Me     Cl                                                      1932  5-Me 1 Cl Me     SO.sub.2 Me                                             1933  5-Me 1 Cl OMe    Cl                                                      1934  5-Me 1 Cl OMe    Br                                                      1935  5-Me 1 Cl OMe    SO.sub.2 Me                                             1936  5-Me 1 Cl OEt    Br                                                      1937  5-Me 1 Br H      OMe                                                     1938  5-Me 1 F  H      F                                                       1939  5-Me 1 I  I      I                                                       1940  5-Me 1 Me H      CN                                                      1941  5-Me 1 Me H      Me                                                      1942  5-Me 1 Me H      OMe                                                     1943  5-Me 1 Me Cl     Cl                                                      1944  5-Me 1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             1945  5-Me 1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             1946  5-Me 1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             1947  5-Me 1 NO.sub.2                                                                          H      Cl                                                      1948  5-Me 1 NO.sub.2                                                                          H      Br                                                      1949  5-Me 1 NO.sub.2                                                                          H      F                                                       1950  5-Me 1 NO.sub.2                                                                          H      CN                                                      1951  5-Me 1 NO.sub.2                                                                          H      SMe                                                     1952  5-Me 1 NO.sub.2                                                                          H      CF.sub.3                                                1953  5-Me 1 NO.sub.2                                                                          OMe    Cl                                                      1954  5-Me 1 NO.sub.2                                                                          OMe    CF.sub.3                                                1955  5-Me 1 CF.sub.3                                                                          H      Cl                                                      1956  5-Me 1 CF.sub.3                                                                          H      Br                                                      1957  5-Me 1 CF.sub.3                                                                          H      SMe                                                     1958  5-Me 1 CF.sub.3                                                                          H      CF.sub.3                                                1959  5-Me 1 OMe                                                                               H      Cl                                                      1960  5-Me 1 OMe                                                                               H      OMe                                                     1961  5-Me 2 Cl H      Cl                                                      1962  5-Me 2 Cl H      SO.sub.2 Me                                             1963  5-Me 2 Cl H      NO.sub.2                                                1964  5-Me 2 Cl H      OMe                                                     1965  5-Me 2 Cl H      Me                                                      1966  5-Me 2 Cl H      Br                                                      1967  5-Me 2 Cl H      F                                                       1968  5-Me 2 Cl H      SMe                                                     1969  5-Me 2 Cl H      S(O)Me                                                  1970  5-Me 2 Cl H      CF.sub.3                                                1971  5-Me 2 Cl H      CN                                                      1972  5-Me 2 Cl Cl     Cl                                                      1973  5-Me 2 Cl Cl     OMe                                                     1974  5-Me 2 Cl Cl     SMe                                                     1975  5-Me 2 Cl Cl     SO.sub.2 Me                                             1976  5-Me 2 Cl Me     Cl                                                      1977  5-Me 2 Cl Me     SO.sub. 2 Me                                            1978  5-Me 2 Cl OMe    Cl                                                      1979  5-Me 2 Cl OMe    Br                                                      1980  5-Me 2 Cl OMe    SO.sub.2 Me                                             1981  5-Me 2 Cl OEt    Br                                                      1982  5-Me 2 Br H      OMe                                                     1983  5-Me 2 F  H      F                                                       1984  5-Me 2 I  I      I                                                       1985  5-Me 2 Me H      CN                                                      1986  5-Me 2 Me H      Me                                                      1987  5-Me 2 Me H      OMe                                                     1988  5-Me 2 Me Cl     Cl                                                      1989  5-Me 2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             1990  5-Me 2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             1991  5-Me 2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             1992  5-Me 2 NO.sub.2                                                                          H      Cl                                                      1993  5-Me 2 NO.sub.2                                                                          H      Br                                                      1994  5-Me 2 NO.sub.2                                                                          H      F                                                       1995  5-Me 2 NO.sub.2                                                                          H      CN                                                      1996  5-Me 2 NO.sub.2                                                                          H      SMe                                                     1997  5-Me 2 NO.sub.2                                                                          H      CF.sub.3                                                1998  5-Me 2 NO.sub.2                                                                          OMe    Cl                                                      1999  5-Me 2 NO.sub.2                                                                          OMe    CF.sub.3                                                2000  5-Me 2 CF.sub.3                                                                          H      Cl                                                      2001  5-Me 2 CF.sub.3                                                                          H      Br                                                      2002  5-Me 2 CF.sub.3                                                                          H      SMe                                                     2003  5-Me 2 CF.sub.3                                                                          H      CF.sub.3                                                2004  5-Me 2 OMe                                                                               H      Cl                                                      2005  5-Me 2 OMe                                                                               H      OMe                                                     2006  4.4-diMe                                                                            0 Cl H      Cl                                                      2007  4.4-diMe                                                                            0 Cl H      SO.sub.2 Me                                             2008  4.4-diMe                                                                            0 Cl H      NO.sub.2                                                2009  4.4-diMe                                                                            0 Cl H      OMe                                                     2010  4.4-diMe                                                                            0 Cl H      Me                                                      2011  4.4-diMe                                                                            0 Cl H      Br                                                      2012  4.4-diMe                                                                            0 Cl H      F                                                       2013  4.4-diMe                                                                            0 Cl H      SMe                                                     2014  4.4-diMe                                                                            0 Cl H      S(O)Me                                                  2015  4.4-diMe                                                                            0 Cl H      CF.sub.3                                                2016  4.4-diMe                                                                            0 Cl H      CN                                                      2017  4.4-diMe                                                                            0 Cl Cl     Cl                                                      2018  4.4-diMe                                                                            0 Cl Cl     OMe                                                     2019  4.4-diMe                                                                            0 Cl Cl     SMe                                                     2020  4.4-diMe                                                                            0 Cl Cl     SO.sub.2 Me                                             2021  4.4-diMe                                                                            0 Cl Me     Cl                                                      2022  4.4-diMe                                                                            0 Cl Me     SO.sub.2 Me                                             2023  4.4-diMe                                                                            0 Cl OMe    Cl                                                      2024  4.4-diMe                                                                            0 Cl OMe    Br                                                      2025  4.4-diMe                                                                            0 Cl OMe    SO.sub.2 Me                                             2026  4.4-diMe                                                                            0 Cl OEt    Br                                                      2027  4.4-diMe                                                                            0 Br H      OMe                                                     2028  4.4-diMe                                                                            0 F  H      F                                                       2029  4.4-diMe                                                                            0 I  I      I                                                       2030  4.4-diMe                                                                            0 Me H      CN                                                      2031  4.4-diMe                                                                            0 Me H      Me                                                      2032  4.4-diMe                                                                            0 Me H      OMe                                                     2033  4.4-diMe                                                                            0 Me Cl     Cl                                                      2034  4.4-diMe                                                                            0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             2035  4.4-diMe                                                                            0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             2036  4.4-diMe                                                                            0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             2037  4.4-diMe                                                                            0 NO.sub.2                                                                          H      Cl                                                      2038  4.4-diMe                                                                            0 NO.sub.2                                                                          H      Br                                                      2039  4.4-diMe                                                                            0 NO.sub.2                                                                          H      F                                                       2040  4.4-diMe                                                                            0 NO.sub.2                                                                          H      CN                                                      2041  4.4-diMe                                                                            0 NO.sub.2                                                                          H      SMe                                                     2042  4.4-diMe                                                                            0 NO.sub.2                                                                          H      CF.sub.3                                                2043  4.4-diMe                                                                            0 NO.sub.2                                                                          OMe    Cl                                                      2044  4.4-diMe                                                                            0 NO.sub.2                                                                          OMe    CF.sub.3                                                2045  4.4-diMe                                                                            0 CF.sub.3                                                                          H      Cl                                                      2046  4.4-diMe                                                                            0 CF.sub.3                                                                          H      Br                                                      2047  4.4-diMe                                                                            0 CF.sub.3                                                                          H      SMe                                                     2048  4.4-diMe                                                                            0 CF.sub.3                                                                          H      CF.sub.3                                                2049  4.4-diMe                                                                            0 OMe                                                                               H      Cl                                                      2050  4.4-diMe                                                                            0 OMe                                                                               H      OMe                                                     2051  4.4-diMe                                                                            1 Cl H      Cl                                                      2052  4.4-diMe                                                                            1 Cl H      SO.sub.2 Me                                             2053  4.4-diMe                                                                            1 Cl H      NO.sub.2                                                2054  4.4-diMe                                                                            1 Cl H      OMe                                                     2055  4.4-diMe                                                                            1 Cl H      Me                                                      2056  4.4-diMe                                                                            1 Cl H      Br                                                      2057  4.4-diMe                                                                            1 Cl H      F                                                       2058  4.4-diMe                                                                            1 Cl H      SMe                                                     2059  4.4-diMe                                                                            1 Cl H      S(O)Me                                                  2060  4.4-diMe                                                                            1 Cl H      CF.sub.3                                                2061  4.4-diMe                                                                            1 Cl H      CN                                                      2062  4.4-diMe                                                                            1 Cl Cl     Cl                                                      2063  4.4-diMe                                                                            1 Cl Cl     OMe                                                     2064  4.4-diMe                                                                            1 Cl Cl     SMe                                                     2065  4.4-diMe                                                                            1 Cl Cl     SO.sub.2 Me                                             2066  4.4-diMe                                                                            1 Cl Me     Cl                                                      2067  4.4-diMe                                                                            1 Cl Me     SO.sub.2 Me                                             2068  4.4-diMe                                                                            1 Cl OMe    Cl                                                      2069  4.4-diMe                                                                            1 Cl OMe    Br                                                      2070  4.4-diMe                                                                            1 Cl OMe    SO.sub.2 Me                                             2071  4.4-diMe                                                                            1 Cl OEt    Br                                                      2072  4.4-diMe                                                                            1 Br H      OMe                                                     2073  4.4-diMe                                                                            1 F  H      F                                                       2074  4.4-diMe                                                                            1 I  I      I                                                       2075  4.4-diMe                                                                            1 Me H      CN                                                      2076  4.4-diMe                                                                            1 Me H      Me                                                      2077  4.4-diMe                                                                            1 Me H      OMe                                                     2078  4.4-diMe                                                                            1 Me Cl     Cl                                                      2079  4.4-diMe                                                                            1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             2080  4.4-diMe                                                                            1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             2081  4.4-diMe                                                                            1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             2082  4.4-diMe                                                                            1 NO.sub.2                                                                          H      Cl                                                      2083  4.4-diMe                                                                            1 NO.sub.2                                                                          H      Br                                                      2084  4.4-diMe                                                                            1 NO.sub.2                                                                          H      F                                                       2085  4.4-diMe                                                                            1 NO.sub.2                                                                          H      CN                                                      2086  4.4-diMe                                                                            1 NO.sub.2                                                                          H      SMe                                                     2087  4.4-diMe                                                                            1 NO.sub.2                                                                          H      CF.sub.3                                                2088  4.4-diMe                                                                            1 NO.sub.2                                                                          OMe    Cl                                                      2089  4.4-diMe                                                                            1 NO.sub.2                                                                          OMe    CF.sub.3                                                2090  4.4-diMe                                                                            1 CF.sub.3                                                                          H      Cl                                                      2091  4.4-diMe                                                                            1 CF.sub.3                                                                          H      Br                                                      2092  4.4-diMe                                                                            1 CF.sub.3                                                                          H      SMe                                                     2093  4.4-diMe                                                                            1 CF.sub.3                                                                          H      CF.sub.3                                                2094  4.4-diMe                                                                            1 OMe                                                                               H      Cl                                                      2095  4.4-diMe                                                                            1 OMe                                                                               H      OMe                                                     2096  4.4-diMe                                                                            1 Cl H      Cl                                                      2097  4.4-diMe                                                                            2 Cl H      SO.sub.2 Me                                             2098  4.4-diMe                                                                            2 Cl H      NO.sub.2                                                2099  4.4-diMe                                                                            2 Cl H      OMe                                                     2100  4.4-diMe                                                                            2 Cl H      Me                                                      2101  4.4-diMe                                                                            2 Cl H      Br                                                      2102  4.4-diMe                                                                            2 Cl H      F                                                       2103  4.4-diMe                                                                            2 Cl H      SMe                                                     2104  4.4-diMe                                                                            2 Cl H      S(O)Me                                                  2105  4.4-diMe                                                                            2 Cl H      CF.sub.3                                                2106  4.4-diMe                                                                            2 Cl H      CN                                                      2107  4.4-diMe                                                                            2 Cl Cl     Cl                                                      2108  4.4-diMe                                                                            2 Cl Cl     OMe                                                     2109  4.4-diMe                                                                            2 Cl Cl     SMe                                                     2110  4.4-diMe                                                                            2 Cl Cl     SO.sub.2 Me                                             2111  4.4-diMe                                                                            2 Cl Me     Cl                                                      2112  4.4-diMe                                                                            2 Cl Me     SO.sub.2 Me                                             2113  4.4-diMe                                                                            2 Cl OMe    Cl                                                      2114  4.4-diMe                                                                            2 Cl OMe    Br                                                      2115  4.4-diMe                                                                            2 Cl OMe    SO.sub.2 Me                                             2116  4.4-diMe                                                                            2 Cl OEt    Br                                                      2117  4.4-diMe                                                                            2 Br H      OMe                                                     2118  4.0-diMe                                                                            2 F  H      F                                                       2119  4.4-diMe                                                                            2 I  I      I                                                       2120  4.4-diMe                                                                            2 Me H      CN                                                      2121  4.4-diMe                                                                            2 Me H      Me                                                      2122  4.4-diMe                                                                            2 Me H      OMe                                                     2123  4.4-diMe                                                                            2 Me Cl     Cl                                                      2124  4.4-diMe                                                                            2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             2125  4.4-diMe                                                                            2 Me CH.sub. 2 OMe                                                                         SO.sub.2 Me                                             2126  4.4-diMe                                                                            2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             2127  4.4-diMe                                                                            2 NO.sub.2                                                                          H      Cl                                                      2128  4.4-diMe                                                                            2 NO.sub.2                                                                          H      Br                                                      2129  4.4-diMe                                                                            2 NO.sub.2                                                                          H      F                                                       2130  4.4-diMe                                                                            2 NO.sub.2                                                                          H      CN                                                      2131  4.4-diMe                                                                            2 NO.sub.2                                                                          H      SMe                                                     2132  4.4-diMe                                                                            2 NO.sub.2                                                                          H      CF.sub.3                                                2133  4.4-diMe                                                                            2 NO.sub.2                                                                          OMe    Cl                                                      2134  4.4-diMe                                                                            2 NO.sub.2                                                                          OMe    CF.sub.3                                                2135  4.4-diMe                                                                            2 CF.sub.3                                                                          H      Cl                                                      2136  4.4-diMe                                                                            2 CF.sub.3                                                                          H      Br                                                      2137  4.4-diMe                                                                            2 CF.sub.3                                                                          H      SMe                                                     2138  4.4-diMe                                                                            2 CF.sub.3                                                                          H      CF.sub.3                                                2139  4.4-diMe                                                                            2 OMe                                                                               H      Cl                                                      2140  4.4-diMe                                                                            2 OMe                                                                               H      OMe                                                     2141  5.5-diMe                                                                            0 Cl H      Cl                                                      2142  5.5-diMe                                                                            0 Cl H      SO.sub.2 Me                                             2143  5.5-diMe                                                                            0 Cl H      NO.sub.2                                                2144  5.5-diMe                                                                            0 Cl H      OMe                                                     2145  5.5-diMe                                                                            0 Cl H      Me                                                      2146  5.5-diMe                                                                            0 Cl H      Br                                                      2147  5.5-diMe                                                                            0 Cl H      F                                                       2148  5.5-diMe                                                                            0 Cl H      SMe                                                     2149  5.5-diMe                                                                            0 Cl H      S(O)Me                                                  2150  5.5-diMe                                                                            0 Cl H      CF.sub.3                                                2151  5.5-diMe                                                                            0 Cl H      CN                                                      2152  5.5-diMe                                                                            0 Cl Cl     Cl                                                      2153  5.5-diMe                                                                            0 Cl Cl     OMe                                                     2154  5.5-diMe                                                                            0 Cl Cl     SMe                                                     2155  5.5-diMe                                                                            0 Cl Cl     SO.sub.2 Me                                             2156  5.5-diMe                                                                            0 Cl Me     Cl                                                      2157  5.5-diMe                                                                            0 Cl Me     SO.sub.2 Me                                             2158  5.5-diMe                                                                            0 Cl OMe    Cl                                                      2159  5.5-diMe                                                                            0 Cl OMe    Br                                                      2160  5.5-diMe                                                                            0 Cl OMe    SO.sub.2 Me                                             2161  5.5-diMe                                                                            0 Cl OEt    Br                                                      2162  5.5-diMe                                                                            0 Br H      OMe                                                     2163  5.5-diMe                                                                            0 F  H      F                                                       2164  5.5-diMe                                                                            0 I  I      I                                                       2165  5.5-diMe                                                                            0 Me H      CN                                                      2166  5.5-diMe                                                                            0 Me H      Me                                                      2167  5.5-diMe                                                                            0 Me H      OMe                                                     2168  5.5-diMe                                                                            0 Me Cl     Cl                                                      2169  5.5-diMe                                                                            0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             2170  5.5-diMe                                                                            0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             2171  5.5-diMe                                                                            0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             2172  5.5-diMe                                                                            0 NO.sub.2                                                                          H      Cl                                                      2173  5.5-diMe                                                                            0 NO.sub.2                                                                          H      Br                                                      2174  5.5-diMe                                                                            0 NO.sub.2                                                                          H      F                                                       2175  5.5-diMe                                                                            0 NOI.sub.2                                                                         H      CN                                                      2176  5.5-diMe                                                                            0 NO.sub.2                                                                          H      SMe                                                     2177  5.5-diMe                                                                            0 NO.sub.2                                                                          H      CF.sub.3                                                2178  5.5-diMe                                                                            0 NO.sub.2                                                                          OMe    Cl                                                      2179  5.5-diMe                                                                            0 NO.sub.2                                                                          OMe    CF.sub.3                                                2180  5.5-diMe                                                                            0 CF.sub.3                                                                          H      Cl                                                      2181  5.5-diMe                                                                            0 CF.sub.3                                                                          H      Br                                                      2182  5.5-diMe                                                                            0 CF.sub.3                                                                          H      SMe                                                     2183  5.5-diMe                                                                            0 CF.sub.3                                                                          H      CF.sub.3                                                2184  5.5-diMe                                                                            0 OMe                                                                               H      Cl                                                      2185  5.5-diMe                                                                            0 OMe                                                                               H      OMe                                                     2186  5.5-diMe                                                                            1 Cl H      Cl                                                      2187  5.5-diMe                                                                            1 Cl H      SO.sub.2 Me                                             2188  5.5-diMe                                                                            1 Cl H      NO.sub.2                                                2189  5.5-diMe                                                                            1 Cl H      OMe                                                     2190  5.5-diMe                                                                            1 Cl H      Me                                                      2191  5.5-diMe                                                                            1 Cl H      Br                                                      2192  5.5-diMe                                                                            1 Cl H      F                                                       2193  5.5-diMe                                                                            1 Cl H      SMe                                                     2194  5.5-diMe                                                                            1 Cl H      S(O)Me                                                  2195  5.5-diMe                                                                            1 Cl H      CF.sub.3                                                2196  5.5-diMe                                                                            1 Cl H      CN                                                      2197  5.5-diMe                                                                            1 Cl Cl     Cl                                                      2198  5.5-diMe                                                                            1 Cl Cl     OMe                                                     2199  5.5-diMe                                                                            1 Cl Cl     SMe                                                     2200  5.5-diMe                                                                            1 Cl Cl     SO.sub.2 Me                                             2201  5.5-diMe                                                                            1 Cl Me     Cl                                                      2202  5.5-diMe                                                                            1 Cl Me     SO.sub.2 Me                                             2203  5.5-diMe                                                                            1 Cl OMe    Cl                                                      2204  5.5-diMe                                                                            1 Cl OMe    Br                                                      2205  5.5-diMe                                                                            1 Cl OMe    SO.sub.2 Me                                             2206  5.5-diMe                                                                            1 Cl OEt    Br                                                      2207  5.5-diMe                                                                            1 Br H      OMe                                                     2208  5.5-diMe                                                                            1 F  H      F                                                       2209  5.5-diMe                                                                            1 I  I      I                                                       2210  5.5-diMe                                                                            1 Me H      CN                                                      2211  5.5-diMe                                                                            1 Me H      Me                                                      2212  5.5-diMe                                                                            1 Me H      OMe                                                     2213  5.5-diMe                                                                            1 Me Cl     Cl                                                      2214  5.5-diMe                                                                            1 Me CO.sub. 2 Me                                                                          SO.sub.2 Me                                             2215  5.5-diMe                                                                            1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             2216  5.5-diMe                                                                            1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             2217  5.5-diMe                                                                            1 NO.sub.2                                                                          H      Cl                                                      2218  5.5-diMe                                                                            1 NO.sub.2                                                                          H      Br                                                      2219  5.5-diMe                                                                            1 NO.sub.2                                                                          H      F                                                       2220  5.5-diMe                                                                            1 NO.sub.2                                                                          H      CN                                                      2221  5.5-diMe                                                                            1 NO.sub.2                                                                          H      SMe                                                     2222  5.5-diMe                                                                            1 NO.sub.2                                                                          H      CF.sub.3                                                2223  5.5-diMe                                                                            1 NO.sub.2                                                                          OMe    Cl                                                      2224  5.5-diMe                                                                            1 NO.sub.2                                                                          OMe    CF.sub.3                                                2225  5.5-diMe                                                                            1 CF.sub.3                                                                          H      Cl                                                      2226  5.5-diMe                                                                            1 CF.sub.3                                                                          H      Br                                                      2227  5.5-diMe                                                                            1 CF.sub.3                                                                          H      SMe                                                     2228  5.5-diMe                                                                            1 CF.sub.3                                                                          H      CF.sub.3                                                2229  5.5-diMe                                                                            1 OMe                                                                               H      Cl                                                      2230  5.5-diMe                                                                            1 OMe                                                                               H      OMe                                                     2231  5.5-diMe                                                                            2 Cl H      Cl                                                      2232  5.5-diMe                                                                            2 Cl H      SO.sub.2 Me                                             2233  5.5-diMe                                                                            2 Cl H      NO.sub.2                                                2234  5.5-diMe                                                                            2 Cl H      OMe                                                     2235  5.5-diMe                                                                            2 Cl H      Me                                                      2236  5.5-diMe                                                                            2 Cl H      Br                                                      2237  5.5-diMe                                                                            2 Cl H      F                                                       2238  5.5-diMe                                                                            2 Cl H      SMe                                                     2239  5.5-diMe                                                                            2 Cl H      S(O)Me                                                  2240  5.5-diMe                                                                            2 Cl H      CF.sub.3                                                2241  5.5-diMe                                                                            2 Cl H      CN                                                      2242  5.5-diMe                                                                            2 Cl Cl     Cl                                                      2243  5.5-diMe                                                                            2 Cl Cl     OMe                                                     2244  5.5-diMe                                                                            2 Cl Cl     SMe                                                     2245  5.5-diMe                                                                            2 Cl Cl     SO.sub.2 Me                                             2246  5.5-diMe                                                                            2 Cl Me     Cl                                                      2247  5.5-diMe                                                                            2 Cl Me     SO.sub.2 Me                                             2248  5.5-diMe                                                                            2 Cl OMe    Cl                                                      2249  5.5-diMe                                                                            2 Cl OMe    Br                                                      2250  5.5-diMe                                                                            2 Cl OMe    SO.sub.2 Me                                             2251  5.5-diMe                                                                            2 Cl OEt    Br                                                      2252  5.5-diMe                                                                            2 Br H      OMe                                                     2253  5.5-diMe                                                                            2 F  H      F                                                       2254  5.5-diMe                                                                            2 I  I      I                                                       2255  5.5-diMe                                                                            2 Me H      CN                                                      2256  5.5-diMe                                                                            2 Me H      Me                                                      2257  5.5-diMe                                                                            2 Me H      OMe                                                     2258  5.5-diMe                                                                            2 Me Cl     Cl                                                      2259  5.5-diMe                                                                            2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             2260  5.5-diMe                                                                            2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             2261  5.5-diMe                                                                            2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             2262  5.5-diMe                                                                            2 NO.sub.2                                                                          H      Cl                                                      2263  5.5-diMe                                                                            2 NO.sub.2                                                                          H      Br                                                      2264  5.5-diMe                                                                            2 NO.sub.2                                                                          H      F                                                       2265  5.5-diMe                                                                            2 NO.sub.2                                                                          H      CN                                                      2266  5.5-diMe                                                                            2 NO.sub.2                                                                          H      SMe                                                     2267  5.5-diMe                                                                            2 NO.sub.2                                                                          H      CF.sub.3                                                2268  5.5-diMe                                                                            2 NO.sub.2                                                                          OMe    Cl                                                      2269  5.5-diMe                                                                            2 NO.sub.2                                                                          OMe    CF.sub.3                                                2270  5.5-diMe                                                                            2 CF.sub.3                                                                          H      Cl                                                      2271  5.5-diMe                                                                            2 CF.sub.3                                                                          H      Br                                                      2272  5.5-diMe                                                                            2 CF.sub.3                                                                          H      SMe                                                     2273  5.5-diMe                                                                            2 CF.sub.3                                                                          H      CF.sub.3                                                2274  5.5-diMe                                                                            2 OMe                                                                               H      Cl                                                      2275  5.5-diMe                                                                            2 OMe                                                                               H      OMe                                                     2276  4.5-diMe                                                                            0 Cl H      Cl                                                      2277  4.5-diMe                                                                            0 Cl H      SO.sub.2 Me                                             2278  4.5-diMe                                                                            0 Cl H      NO.sub.2                                                2279  4.5-diMe                                                                            0 Cl H      OMe                                                     2280  4.5-diMe                                                                            0 Cl H      Me                                                      2281  4.5-diMe                                                                            0 Cl H      Br                                                      2282  4.5-diMe                                                                            0 Cl H      F                                                       2283  4.5-diMe                                                                            0 Cl H      SMe                                                     2284  4.5-diMe                                                                            0 Cl H      S(O)Me                                                  2285  4.5-diMe                                                                            0 Cl H      CF.sub.3                                                2286  4.5-diMe                                                                            0 Cl H      CN                                                      2287  4.5-diMe                                                                            0 Cl Cl     Cl                                                      2288  4.5-diMe                                                                            0 Cl Cl     OMe                                                     2289  4.5-diMe                                                                            0 Cl Cl     SMe                                                     2290  4.5-diMe                                                                            0 Cl Cl     SO.sub.2 Me                                             2291  4.5-diMe                                                                            0 Cl Me     Cl                                                      2292  4.5-diMe                                                                            0 Cl Me     SO.sub.2 Me                                             2293  4.5-diMe                                                                            0 Cl OMe    Cl                                                      2294  4.5-diMe                                                                            0 Cl OMe    Br                                                      2295  4.5-diMe                                                                            0 Cl OMe    SO.sub.2 Me                                             2296  4.5-diMe                                                                            0 Cl OEt    Br                                                      2297  4.5-diMe                                                                            0 Br H      OMe                                                     2298  4.5-diMe                                                                            0 F  H      F                                                       2299  4.5-diMe                                                                            0 I  I      I                                                       2300  4.5-diMe                                                                            0 Me H      CN                                                      2301  4.5-diMe                                                                            0 Me H      Me                                                      2302  4.5-diMe                                                                            0 Me H      OMe                                                     2303  4.5-diMe                                                                            0 Me Cl     Cl                                                      2304  4.5-diMe                                                                            0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             2305  4.5-diMe                                                                            0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             2306  4.5-diMe                                                                            0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             2307  4.5-diMe                                                                            0 NO.sub.2                                                                          H      Cl                                                      2308  4.5-diMe                                                                            0 NO.sub.2                                                                          H      Br                                                      2309  4.5-diMe                                                                            0 NO.sub.2                                                                          H      F                                                       2310  4.5-diMe                                                                            0 NO.sub.2                                                                          H      CN                                                      2311  4.5-diMe                                                                            0 NO.sub.2                                                                          H      SMe                                                     2312  4.5-diMe                                                                            0 NO.sub.2                                                                          H      CF.sub.3                                                2313  4.5-diMe                                                                            0 NO.sub.2                                                                          OMe    Cl                                                      2314  4.5-diMe                                                                            0 NO.sub.2                                                                          OMe    CF.sub.3                                                2315  4.5-diMe                                                                            0 CF.sub.3                                                                          H      Cl                                                      2316  4.5-diMe                                                                            0 CF.sub.3                                                                          H      Br                                                      2317  4.5-diMe                                                                            0 CF.sub.3                                                                          H      SMe                                                     2318  4.5-diMe                                                                            0 CF.sub.3                                                                          H      CF.sub.3                                                2319  4.5-diMe                                                                            0 OMe                                                                               H      Cl                                                      2320  4.5-diMe                                                                            0 OMe                                                                               H      OMe                                                     2321  4.5-diMe                                                                            1 Cl H      Cl                                                      2322  4.5-diMe                                                                            1 Cl H      SO.sub.2 Me                                             2323  4.5-diMe                                                                            1 Cl H      NO.sub.2                                                2324  4.5-diMe                                                                            1 Cl H      OMe                                                     2325  4.5-diMe                                                                            1 Cl H      Me                                                      2326  4.6-diMe                                                                            1 Cl H      Br                                                      2327  4.5-diMe                                                                            1 Cl H      F                                                       2328  4.5-diMe                                                                            1 Cl H      SMe                                                     2329  4.5-diMe                                                                            1 Cl H      S(O)Me                                                  2330  4.5-diMe                                                                            1 Cl H      CF.sub.3                                                2331  4.5-diMe                                                                            1 Cl H      CN                                                      2332  4.5-diMe                                                                            1 Cl Cl     Cl                                                      2333  4.5-diMe                                                                            1 Cl Cl     OMe                                                     2334  4.5-diMe                                                                            1 Cl Cl     SMe                                                     2335  4.5-diMe                                                                            1 Cl Cl     SO.sub.2 Me                                             2336  4.5-diMe                                                                            1 Cl Me     Cl                                                      2337  4.5-diMe                                                                            1 Cl Me     SO.sub.2 Me                                             2338  4.5-diMe                                                                            1 Cl OMe    Cl                                                      2339  4.5-diMe                                                                            1 Cl OMe    Br                                                      2340  4.5-diMe                                                                            1 Cl OMe    SO.sub.2 Me                                             2341  4.5-diMe                                                                            1 Cl OEt    Br                                                      2342  4.5-diMe                                                                            1 Br H      OMe                                                     2343  4.5-diMe                                                                            1 F  H      F                                                       2344  4.5-diMe                                                                            1 I  I      I                                                       2345  4.5-diMe                                                                            1 Me H      CN                                                      2346  4.5-diMe                                                                            1 Me H      Me                                                      2347  4.5-diMe                                                                            1 Me H      OMe                                                     2348  4.5-diMe                                                                            1 Me Cl     Cl                                                      2349  4.5-diMe                                                                            1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             2350  4.5-diMe                                                                            1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             2351  4.5-diMe                                                                            1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             2352  4.5-diMe                                                                            1 NO.sub.2                                                                          H      Cl                                                      2353  4.5-diMe                                                                            1 NO.sub.2                                                                          H      Br                                                      2354  4.5-diMe                                                                            1 NO.sub.2                                                                          H      F                                                       2355  4.5-diMe                                                                            1 NO.sub.2                                                                          H      CN                                                      2356  4.5-diMe                                                                            1 NO.sub.2                                                                          H      SMe                                                     2357  4.5-diMe                                                                            1 NO.sub.2                                                                          H      CF.sub.3                                                2358  4.5-diMe                                                                            1 NO.sub.2                                                                          OMe    Cl                                                      2359  4.5-diMe                                                                            1 NO.sub.2                                                                          OMe    CF.sub.3                                                2360  4.5-diMe                                                                            1 CF.sub.3                                                                          H      Cl                                                      2361  4.5-diMe                                                                            1 CF.sub.3                                                                          H      Br                                                      2362  4.5-diMe                                                                            1 CF.sub.3                                                                          H      SMe                                                     2363  4.5-diMe                                                                            1 CF.sub.3                                                                          H      CF.sub.3                                                2364  4.5-diMe                                                                            1 OMe                                                                               H      Cl                                                      2365  4.5-diMe                                                                            1 OMe                                                                               H      OMe                                                     2366  4.5-diMe                                                                            2 Cl H      Cl                                                      2367  4.5-diMe                                                                            2 Cl H      SO.sub.2 Me                                             2368  4.5-diMe                                                                            2 Cl H      NO.sub.2                                                2369  4.5-diMe                                                                            2 Cl H      OMe                                                     2370  4.5-diMe                                                                            2 Cl H      Me                                                      2371  4.5-diMe                                                                            2 Cl H      Br                                                      2372  4.5-diMe                                                                            2 Cl H      F                                                       2373  4.5-diMe                                                                            2 Cl H      SMe                                                     2374  4.5-diMe                                                                            2 Cl H      S(O)Me                                                  2375  4.5-diMe                                                                            2 Cl H      CF.sub.3                                                2376  4.5-diMe                                                                            2 Cl H      CN                                                      2377  4.5-diMe                                                                            2 Cl Cl     Cl                                                      2378  4.5-diMe                                                                            2 Cl Cl     OMe                                                     2379  4.5-diMe                                                                            2 Cl Cl     SMe                                                     2380  4.5-diMe                                                                            2 Cl Cl     SO.sub.2 Me                                             2381  4.5-diMe                                                                            2 Cl Me     Cl                                                      2382  4.5-diMe                                                                            2 Cl Me     SO.sub.2 Me                                             2383  4.5-diMe                                                                            2 Cl OMe    Cl                                                      2384  4.5-diMe                                                                            2 Cl OMe    Br                                                      2385  4.5-diMe                                                                            2 Cl OMe    SO.sub.2 Me                                             2386  4.5-diMe                                                                            2 Cl OEt    Br                                                      2387  4.5-diMe                                                                            2 Br H      OMe                                                     2388  4.5-diMe                                                                            2 F  H      F                                                       2389  4.5-diMe                                                                            2 I  I      I                                                       2390  4.5-dime                                                                            2 Me H      CN                                                      2391  4.5-diMe                                                                            2 Me H      Me                                                      2392  4.5-diMe                                                                            2 Me H      OMe                                                     2393  4.5-diMe                                                                            2 Me Cl     Cl                                                      2394  4.5-diMe                                                                            2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             2395  4.5-diMe                                                                            2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             2396  4.5-diMe                                                                            2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             2397  4.5-diMe                                                                            2 NO.sub.2                                                                          H      Cl                                                      2398  4.5-diMe                                                                            2 NO.sub.2                                                                          H      Br                                                      2399  4.5-diMe                                                                            2 NO.sub.2                                                                          H      F                                                       2400  4.5-diMe                                                                            2 NO.sub.2                                                                          H      CN                                                      2401  4.5-diMe                                                                            2 NO.sub.2                                                                          H      SMe                                                     2402  4.5-diMe                                                                            2 NO.sub.2                                                                          H      CF.sub.3                                                2403  4.5-diMe                                                                            2 NO.sub.2                                                                          OMe    Cl                                                      2404  4.5-diMe                                                                            2 NO.sub.2                                                                          OMe    CF.sub.3                                                2405  4.5-diMe                                                                            2 CF.sub.3                                                                          H      Cl                                                      2406  4.5-diMe                                                                            2 CF.sub.3                                                                          H      Br                                                      2407  4.5-diMe                                                                            2 CF.sub.3                                                                          H      SMe                                                     2408  4.5-diMe                                                                            2 CF.sub.3                                                                          H      CF.sub.3                                                2409  4.5-diMe                                                                            2 OMe                                                                               H      Cl                                                      2410  4.5-diMe                                                                            2 OMe                                                                               H      OMe                                                     2411  4-Ph 0 Cl H      Cl                                                      2412  4-Ph 0 Cl H      SO.sub.2 Me                                             2413  4-Ph 0 Cl H      NO.sub.2                                                2414  4-Ph 0 Cl H      OMe                                                     2415  4-Ph 0 Cl H      Br                                                      2417  4-Ph 0 Cl H      F                                                       2418  4-Ph 0 Cl H      SMe                                                     2419  4-Ph 0 Cl H      S(O)Me                                                  2420  4-Ph 0 Cl H      CF.sub.3                                                2421  4-Ph 0 Cl H      CN                                                      2422  4-Ph 0 Cl Cl     Cl                                                      2423  4-Ph 0 Cl Cl     OMe                                                     2425  4-Ph 0 Cl Cl     SO.sub.2 Me                                             2426  4-Ph 0 Cl Me     Cl                                                      2427  4-Ph 0 Cl Me     SO.sub.2 Me                                             2428  4-Ph 0 Cl OMe    Cl                                                      2429  4-Ph 0 Cl OMe    Br                                                      2430  4-Ph 0 Cl OMe    SO.sub.2 Me                                             2431  4-Ph 0 Cl OEt    Br                                                      2432  4-Ph 0 Br H      OMe                                                     2433  4-Ph 0 F  H      F                                                       2434  4-Ph 0 I  I      I                                                       2435  4-Ph 0 Me H      CN                                                      2436  4-Ph 0 Me H      Me                                                      2437  4-Ph 0 Me H      OMe                                                     2438  4-Ph 0 Me Cl     Cl                                                      2439  4-Ph 0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             2440  4-Ph 0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             2441  4-Ph 0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             2442  4-Ph 0 NO.sub.2                                                                          H      Cl                                                      2443  4-Ph 0 NO.sub.2                                                                          H      Br                                                      2444  4-Ph 0 NO.sub.2                                                                          H      F                                                       2445  4-Ph 0 NO.sub.2                                                                          H      CN                                                      2446  4-Ph 0 NO.sub.2                                                                          H      SMe                                                     2447  4-Ph 0 NO.sub.2                                                                          H      CF.sub.3                                                2448  4-Ph 0 NO.sub.2                                                                          OMe    Cl                                                      2449  4-Ph 0 NO.sub.2                                                                          OMe    CF.sub.3                                                2450  4-Ph 0 CF.sub.3                                                                          H      Cl                                                      2451  4-Ph 0 CF.sub.3                                                                          H      Br                                                      2452  4-Ph 0 CF.sub.3                                                                          H      SMe                                                     2453  4-Ph 0 CF.sub.3                                                                          H      CF.sub.3                                                2454  4-Ph 0 OMe                                                                               H      Cl                                                      2455  4-Ph 0 OMe                                                                               H      OMe                                                     2456  4-Ph 1 Cl H      Cl                                                      2457  4-Ph 1 Cl H      SO.sub.2 Me                                             2458  4-Ph 1 Cl H      NO.sub.2                                                2459  4-Ph 1 Cl H      OMe                                                     2460  4-Ph 1 Cl H      Me                                                      2461  4-Ph 1 Cl H      Br                                                      2462  4-Ph 1 Cl H      F                                                       2463  4-Ph 1 Cl H      SMe                                                     2464  4-Ph 1 Cl H      S(O)Me                                                  2465  4-Ph 1 Cl H      CF.sub.3                                                2466  4-Ph 1 Cl H      CN                                                      2467  4-Ph 1 Cl Cl     Cl                                                      2468  4-Ph 1 Cl Cl     OMe                                                     2469  4-Ph 1 Cl Cl     SMe                                                     2470  4-Ph 1 Cl Cl     SO.sub.2 Me                                             2471  4-Ph 1 Cl Me     Cl                                                      2472  4-Ph 1 Cl Me     SO.sub.2 Me                                             2473  4-Ph 1 Cl OMe    Cl                                                      2474  4-Ph 1 Cl OMe    Br                                                      2475  4-Ph 1 Cl OMe    SO.sub.2 Me                                             2476  4-Ph 1 Cl OEt    Br                                                      2477  4-Ph 1 Br H      OMe                                                     2478  4-Ph 1 F  H      F                                                       2479  4-Ph 1 I  I      I                                                       2480  4-Ph 1 Me H      CN                                                      2481  4-Ph 1 Me H      Me                                                      2482  4-Ph 1 Me H      OMe                                                     2483  4-Ph 1 Me Cl     Cl                                                      2484  4-Ph 1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             2485  4-Ph 1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             2486  4-Ph 1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             2487  4-Ph 1 NO.sub.2                                                                          H      Cl                                                      2488  4-Ph 1 NO.sub.2                                                                          H      Br                                                      2489  4-Ph 1 NO.sub.2                                                                          H      F                                                       2490  4-Ph 1 NO.sub.2                                                                          H      CN                                                      2491  4-Ph 1 NO.sub.2                                                                          H      SMe                                                     2492  4-Ph 1 NO.sub.2                                                                          H      CF.sub.3                                                2493  4-Ph 1 NO.sub.2                                                                          OMe    Cl                                                      2494  4-Ph 1 NO.sub.2                                                                          OMe    CF.sub.3                                                2495  4-Ph 1 CF.sub.3                                                                          H      Cl                                                      2496  4-Ph 1 CF.sub.3                                                                          H      Br                                                      2497  4-Ph 1 CF.sub.3                                                                          H      SMe                                                     2498  4-Ph 1 CF.sub.3                                                                          H      CF.sub.3                                                2499  4-Ph 1 OMe                                                                               H      Cl                                                      2500  4-Ph 1 OMe                                                                               H      OMe                                                     2501  4-Ph 2 Cl H      Cl                                                      2502  4-Ph 2 Cl H      SO.sub.2 Me                                             2503  4-Ph 2 Cl H      NO.sub.2                                                2504  4-Ph 2 Cl H      OMe                                                     2505  4-Ph 2 Cl H      Me                                                      2506  4-Ph 2 Cl H      Br                                                      2507  4-Ph 2 Cl H      F                                                       2508  4-Ph 2 Cl H      SMe                                                     2509  4-Ph 2 Cl H      S(O)Me                                                  2510  4-Ph 2 Cl H      CF.sub.3                                                2511  4-Ph 2 Cl H      CN                                                      2512  4-Ph 2 Cl Cl     Cl                                                      2513  4-Ph 2 Cl Cl     OMe                                                     2514  4-Ph 2 Cl Cl     SMe                                                     2515  4-Ph 2 Cl Cl     SO.sub.2 Me                                             2516  4-Ph 2 Cl Me     Cl                                                      2517  4-Ph 2 Cl Me     SO.sub.2 Me                                             2518  4-Ph 2 Cl OMe    Cl                                                      2519  4-Ph 2 Cl OMe    Br                                                      2520  4-Ph 2 Cl OMe    SO.sub.2 Me                                             2521  4-Ph 2 Cl OEt    Br                                                      2522  4-Ph 2 Br H      OMe                                                     2523  4-Ph 2 F  H      F                                                       2524  4-Ph 2 I  I      I                                                       2525  4-Ph 2 Me H      CN                                                      2526  4-Ph 2 Me H      Me                                                      2527  4-Ph 2 Me H      OMe                                                     2528  4-Ph 2 Me Cl     Cl                                                      2529  4-Ph 2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             2530  4-Ph 2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             2531  4-Ph 2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             2532  4-Ph 2 NO.sub.2                                                                          H      Cl                                                      2533  4-Ph 2 NO.sub.2                                                                          H      Br                                                      2534  4-Ph 2 NO.sub.2                                                                          H      F                                                       2535  4-Ph 2 NO.sub.2                                                                          H      CN                                                      2536  4-Ph 2 NO.sub.2                                                                          H      SMe                                                     2537  4-Ph 2 NO.sub.2                                                                          H      CF.sub.3                                                2538  4-Ph 2 NO.sub.2                                                                          OMe    Cl                                                      2539  4-Ph 2 NO.sub.2                                                                          OMe    CF.sub.3                                                2540  4-Ph 2 CF.sub.3                                                                          H      Cl                                                      2541  4-Ph 2 CF.sub.3                                                                          H      Br                                                      2542  4-Ph 2 CF.sub.3                                                                          H      SMe                                                     2543  4-Ph 2 CF.sub.3                                                                          H      CF.sub.3                                                2544  4-Ph 2 OMe                                                                               H      Cl                                                      2545  4-Ph 2 OMe                                                                               H      OMe                                                     2546  5-Ph 0 Cl H      Cl                                                      2547  5-Ph 0 Cl H      SO.sub.2 Me                                             2548  5-Ph 0 Cl H      NO.sub.2                                                2549  5-Ph 0 Cl H      OMe                                                     2550  5-Ph 0 Cl H      Me                                                      2551  5-Ph 0 Cl H      Br                                                      2552  5-Ph 0 Cl H      F                                                       2553  5-Ph 0 Cl H      SMe                                                     2554  5-Ph 0 Cl H      S(O)Me                                                  2555  5-Ph 0 Cl H      CF.sub.3                                                2556  5-Ph 0 Cl H      CN                                                      2557  5-Ph 0 Cl Cl     Cl                                                      2558  5-Ph 0 Cl Cl     OMe                                                     2559  5-Ph 0 Cl Cl     SMe                                                     2560  5-Ph 0 Cl Cl     SO.sub.2 Me                                             2561  5-Ph 0 Cl Me     Cl                                                      2562  5-Ph 0 Cl Me     SO.sub.2 Me                                             2563  5-Ph 0 Cl OMe    Cl                                                      2564  5-Ph 0 Cl OMe    Br                                                      2565  5-Ph 0 Cl OMe    SO.sub.2 Me                                             2566  5-Ph 0 Cl OEt    Br                                                      2567  5-Ph 0 Br H      OMe                                                     2568  5-Ph 0 F  H      F                                                       2569  5-Ph 0 I  I      I                                                       2570  5-Ph 0 Me H      CN                                                      2571  5-Ph 0 Me H      Me                                                      2572  5-Ph 0 Me H      OMe                                                     2573  5-Ph 0 Me Cl     Cl                                                      2574  5-Ph 0 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             2575  5-Ph 0 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             2576  5-Ph 0 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             2577  5-Ph 0 NO.sub.2                                                                          H      Cl                                                      2578  5-Ph 0 NO.sub.2                                                                          H      Br                                                      2579  5-Ph 0 NO.sub.2                                                                          H      F                                                       2580  5-Ph 0 NO.sub.2                                                                          H      CN                                                      2581  5-Ph 0 NO.sub.2                                                                          H      SMe                                                     2582  5-Ph 0 NO.sub.2                                                                          H      CF.sub.3                                                2583  5-Ph 0 NO.sub.2                                                                          OMe    Cl                                                      2584  5-Ph 0 NO.sub.2                                                                          OMe    CF.sub.3                                                2585  5-Ph 0 CF.sub.3                                                                          H      Cl                                                      2586  5-Ph 0 CF.sub.3                                                                          H      Br                                                      2587  5-Ph 0 CF.sub.3                                                                          H      SMe                                                     2588  5-Ph 0 CF.sub.3                                                                          H      CF.sub.3                                                2589  5-Ph 0 OMe                                                                               H      Cl                                                      2590  5-Ph 0 OMe                                                                               H      OMe                                                     2591  5-Ph 1 Cl H      Cl                                                      2592  5-Ph 1 Cl H      SO.sub.2 Me                                             2593  5-Ph 1 Cl H      NO.sub.2                                                2594  5-Ph 1 Cl H      OMe                                                     2595  5-Ph 1 Cl H      Me                                                      2596  5-Ph 1 Cl H      Br                                                      2597  5-Ph 1 Cl H      F                                                       2598  5-Ph 1 Cl H      SMe                                                     2599  5-Ph 1 Cl H      S(O)Me                                                  2600  5-Ph 1 Cl H      CF.sub.3                                                2601  5-Ph 1 Cl H      CN                                                      2602  5-Ph 1 Cl Cl     Cl                                                      2603  5-Ph 1 Cl Cl     OMe                                                     2604  5-Ph 1 Cl Cl     SMe                                                     2605  5-Ph 1 Cl Cl     SO.sub.2 Me                                             2606  5-Ph 1 Cl Me     Cl                                                      2607  5-Ph 1 Cl Me     SO.sub.2 Me                                             2608  5-Ph 1 Cl OMe    Cl                                                      2609  5-Ph 1 Cl OMe    Br                                                      2610  5-Ph 1 Cl OMe    SO.sub.2 Me                                             2611  5-Ph 1 Cl OEt    Br                                                      2612  5-Ph 1 Br H      OMe                                                     2613  5-Ph 1 F  H      F                                                       2614  5-Ph 1 I  I      I                                                       2615  5-Ph 1 Me H      CN                                                      2616  5-Ph 1 Me H      Me                                                      2617  5-Ph 1 Me H      OMe                                                     2618  5-Ph 1 Me Cl     Cl                                                      2619  5-Ph 1 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             2620  5-Ph 1 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             2621  5-Ph 1 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             2622  5-Ph 1 NO.sub.2                                                                          H      Cl                                                      2623  5-Ph 1 NO.sub.2                                                                          H      Br                                                      2624  5-Ph 1 NO.sub.2                                                                          H      F                                                       2625  5-Ph 1 NO.sub.2                                                                          H      CN                                                      2626  5-Ph 1 NO.sub.2                                                                          H      SMe                                                     2627  5-Ph 1 NO.sub.2                                                                          H      CF.sub. 3                                               2628  5-Ph 1 NO.sub.2                                                                          OMe    Cl                                                      2629  5-Ph 1 NO.sub.2                                                                          OMe    CF.sub.3                                                2630  5-Ph 1 CF.sub.3                                                                          H      Cl                                                      2631  5-Ph 1 CF.sub.3                                                                          H      Br                                                      2632  5-Ph 1 CF.sub.3                                                                          H      SMe                                                     2633  5-Ph 1 CF.sub.3                                                                          H      CF.sub.3                                                2634  5-Ph 1 OMe                                                                               H      Cl                                                      2635  5-Ph 1 OMe                                                                               H      OMe                                                     2636  5-Ph 1 Cl H      Cl                                                      2637  5-Ph 2 Cl H      SO.sub.2 Me                                             2638  5-Ph 2 Cl H      NO.sub.2                                                2639  5-Ph 2 Cl H      OMe                                                     2640  5-Ph 2 Cl H      Me                                                      2641  5-Ph 2 Cl H      Br                                                      2642  5-Ph 2 Cl H      F                                                       2643  5-Ph 2 Cl H      SMe                                                     2644  5-Ph 2 Cl H      S(O)Me                                                  2645  5-Ph 2 Cl H      CF.sub.3                                                2646  5-Ph 2 Cl H      CN                                                      2647  5-Ph 2 Cl Cl     Cl                                                      2648  5-Ph 2 Cl Cl     OMe                                                     2649  5-Ph 2 Cl Cl     SMe                                                     2650  5-Ph 2 Cl Cl     SO.sub.2 Me                                             2651  5-Ph 2 Cl Me     Cl                                                      2652  5-Ph 2 Cl Me     SO.sub.2 Me                                             2653  5-Ph 2 Cl OMe    Cl                                                      2654  5-Ph 2 Cl OMe    Br                                                      2655  5-Ph 2 Cl OMe    SO.sub.2 Me                                             2656  5-Ph 2 Cl OEt    Br                                                      2657  5-Ph 2 Br H      OMe                                                     2658  5-Ph 2 F  H      F                                                       2659  5-Ph 2 I  I      I                                                       2660  5-Ph 2 Me H      CN                                                      2661  5-Ph 2 Me H      Me                                                      2662  5-Ph 2 Me H      OMe                                                     2663  5-Ph 2 Me Cl     Cl                                                      2664  5-Ph 2 Me CO.sub.2 Me                                                                           SO.sub.2 Me                                             2665  5-Ph 2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             2665  5-Ph 2 Me CH.sub.2 OMe                                                                          SO.sub.2 Me                                             2666  5-Ph 2 Me CH(Me)OMe                                                                             SO.sub.2 Me                                             2667  5-Ph 2 NO.sub.2                                                                          H      Cl                                                      2668  5-Ph 2 NO.sub.2                                                                          H      Br                                                      2669  5-Ph 2 NO.sub.2                                                                          H      F                                                       2670  5-Ph 2 NO.sub.2                                                                          H      CN                                                      2671  5-Ph 2 NO.sub.2                                                                          H      SMe                                                     2672  5-Ph 2 NO.sub.2                                                                          H      CF.sub.3                                                2673  5-Ph 2 NO.sub.2                                                                          OMe    Cl                                                      2674  5-Ph 2 NO.sub.2                                                                          OMe    CF.sub.3                                                2675  5-Ph 2 CF.sub.3                                                                          H      Cl                                                      2676  5-Ph 2 CF.sub.3                                                                          H      Br                                                      2677  5-Ph 2 CF.sub.3                                                                          H      SMe                                                     2678  5-Ph 2 CF.sub.3                                                                          H      CF.sub.3                                                2679  5-Ph 2 OMe                                                                               H      Cl                                                      2680  5-Ph 2 OMe                                                                               H      OMe                                                     __________________________________________________________________________

                  TABLE 3                                                          ______________________________________                                         Com-                                                                           pound                                                                          No. of                                                                         the    Dose                                                                    present                                                                               (kg/                                                                    invention                                                                             ha)    EC     DI  CY   SO   GA   RO   ZE   TR                           ______________________________________                                          1     0.5    5      5   5    5    5    5    0    0                                   1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                             7     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            16     0.5    5      5   5    5    5    5    0    0                                   1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            17     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            29     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            30     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            32     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            37     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            1736   1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            ______________________________________                                    

                  TABLE 3                                                          ______________________________________                                         Com-                                                                           pound                                                                          No. of                                                                         the    Dose                                                                    present                                                                               (kg/                                                                    invention                                                                             ha)    EC     DI  CY   SO   GA   RO   ZE   TR                           ______________________________________                                          1     0.5    5      5   5    5    5    5    0    0                                   1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                             7     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            16     0.5    5      5   5    5    5    5    0    0                                   1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            17     0.5    5      5   5    5    5    5    0    0                                   1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            30     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            32     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            37     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            1736   1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            ______________________________________                                     

What is claimed is:
 1. A substituted benzoyl derivative of the formula: ##STR18## wherein R is a lower alkyl group, or a phenyl group unsubstituted or substituted by a lower alkyl group, halogen atom or a lower alkoxy group;n is an integer of 3; m is an integer of from 0 to 6, and when m is an integer of from 2 to 6, the plurality of R is the same or different from one another; l is an integer of 0, 1 or 2; X is a halogen atom, a nitro group, a cyano group, a lower alkyl group, a lower alkoxy group, or a lower haloalkyl group; Y is a hydrogen atom, a halogen atom, a nitro group, a lower alkyl group unsubstituted or substituted by a halogen atom or a lower alkoxy group, a lower alkoxy group, or a lower alkoxy carbonyl group; and Z is a halogen atom, a nitro group, a cyano group, a trifluoromethyl group, a lower alkoxy group, a lower alkylthio group, a lower haloalkylthio group, a lower alkylsulfinyl group, a lower haloalkylsulfinyl group, a lower alkylsulfonyl group, or a lower haloalkylsulfonyl group.
 2. The substituted benzoyl derivative of the formula I according to claim 1, wherein Z is a halogen atom, a nitro group, a cyano group, a trifluoromethyl group, a lower alkoxy group, a lower alkylthio group or a lower alkylsulfonyl group.
 3. The substituted benzoyl derivative of the formula I according to claim 1, wherein n is an integer of 3; m is an integer of 0 or 1; l is an integer of 0 or 1; and Z is a halogen atom, a nitro group, a cyano group, a trifluoromethyl group, a lower alkoxy group, a lower alkylthio group or a lower alkylsulfonyl group.
 4. A substituted benzoyl derivative of the formula: ##STR19## wherein R is a hydrogen atom or a lower alkyl group; l is an integer of 0 or 1;X is a halogen atom or a nitro group; Y is a hydrogen atom or a lower alkyl group; and Z is a halogen atom or a trifluoromethyl group. 